Kelch repeat proteins control yeast PKA activity in response to nutrient availability

Cell Cycle

Volumn 10, Issue 5, 2011, Pages 767-770

  Budhwar, Roli ^a   Fang, Guoqiang ^a   Hirsch, Jeanne P ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Kelch repeat proteins; Nutritional signaling; Protein kinase A; Saccharomyces cerevisiae

Indexed keywords

CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN; PROTEIN BCY1; PROTEIN GPB1; PROTEIN GPB2; UNCLASSIFIED DRUG;

CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; NONHUMAN; NUTRIENT AVAILABILITY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; YEAST;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 79952327927     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.5.14828     Document Type: Review

References (22)

1. Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, et al. Dynamics of signaling by PKA. Biochim Biophys Acta 2005; 1754:25-37; PMID: 16214430.
2. Walsh DA, Perkins JP, Krebs EG. An adenosine 3′,5′- monophosphate-dependant protein kinase from rabbit skeletal muscle. J Biol Chem 1968; 243:3763-5; PMID: 4298072.
3. Rubio-Texeira M, Van Zeebroeck G, Voordeckers K, Thevelein JM. Saccharomyces cerevisiae plasma membrane nutrient sensors and their role in PKA signaling. FEMS Yeast Res 2009; 10:134-49; PMID: 19849717.
4. Xue Y, Batlle M, Hirsch JP. GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Gα subunit and functions in a Ras-independent pathway. EMBO J 1998; 17:1996-2007; PMID: 9524122.
5. Kraakman L, Lemaire K, Ma P, Teunissen AWRH, Donaton MCV, Van Dijck P, et al. A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol 1999; 32:1002-12; PMID: 10361302.
6. Rolland F, de Winde JH, Lemaire K, Boles E, Thevelein JM, Winderickx J. Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process. Mol Microbiol 2000; 38:348-58; PMID: 11069660.
7. Welton RM, Hoffman CS. Glucose monitoring in fission yeast via the gpa2 Gα, the git5 Gβ and the git3 putative glucose receptor. Genetics 2000; 156:513-21; PMID: 11014802.
8. Lemaire K, Van de Velde S, Van Dijck P, Thevelein JM. Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Mol Cell 2004; 16:293-9; PMID: 15494315.
9. Batlle M, Lu A, Green DA, Xue Y, Hirsch JP. Krh1p and Krh2p act downstream of the Gpa2p Gα subunit to negatively regulate haploid invasive growth. J Cell Sci 2003; 116:701-10; PMID: 12538771.
10. Harashima T, Heitman J. The Gα protein gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gβ subunits. Mol Cell 2002; 10:163-73; PMID: 12150916.
11. Peeters T, Louwet W, Gelade R, Nauwelaers D, Thevelein JM, Versele M. Kelch-repeat proteins interacting with the Gα protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci USA 2006; 103:13034-9; PMID: 16924114.
12. Adams J, Kelso R, Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol 2000; 10:17-24; PMID: 10603472.
13. Harashima T, Heitman J. Gα subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G Protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae. Mol Biol Cell 2005; 16:4557-71; PMID: 16030250.
14. Harashima T, Anderson S, Yates JR, III, Heitman J. The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 2006; 22:819-30; PMID: 16793550.
15. Niranjan T, Guo X, Victor J, Lu A, Hirsch JP. Kelch repeat protein interacts with the yeast Gα subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 2007; 282:24231-8; PMID: 17584745.
16. Lu A, Hirsch JP. Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by kelch repeat proteins. Eukaryot Cell 2005; 4:1794-800; PMID: 16278446.
17. Peeters T, Versele M, Thevelein JM. Directly from Gα to protein kinase A: The kelch repeat protein bypass of adenylate cyclase. Trends Biochem Sci 2007; 32:547-54; PMID: 17983752.
18. Budhwar R, Lu A, Hirsch JP. Nutrient control of yeast PKA activity involves opposing effects on phosphorylation of the Bcy1 regulatory subunit. Mol Biol Cell 2010; 21:3749-58; PMID: 20826609.
19. Yorimitsu T, Zaman S, Broach JR, Klionsky DJ. Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell 2007; 18:4180-9; PMID: 17699586.
20. Griffioen G, Branduardi P, Ballarini A, Anghileri P, Norbeck J, Baroni MD, et al. Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain. Mol Cell Biol 2001; 21:511-23; PMID: 11134339.
21. Griffioen G, Anghileri P, Imre E, Baroni MD, Ruis H. Nutritional control of nucleocytoplasmic localization of cAMP-dependent protein kinase catalytic and regulatory subunits in Saccharomyces cerevisiae. J Biol Chem 2000; 275:1449-56; PMID: 10625697.
22. Portela P, Moreno S. Glucose-dependent activation of protein kinase A activity in Saccharomyces cerevisiae and phosphorylation of its TPK1 catalytic subunit. Cell Signal 2006; 18:1072-86; PMID: 16226873.