Estimation of nevirapine from human plasma by LC-ESI-MS/MS: A pharmacokinetic application

Journal of Bioequivalence and Bioavailability

Volumn 3, Issue 1, 2011, Pages 020-025

  Ghosh, Chinmoy ^a,b   Gaur, Shashank ^a   Singh, Ajay ^a   Shinde, Chandrakanta P ^b   Chakraborty, Bhaswat S ^a  

^a Cadila Pharmaceuticals Limited   (India)

^b JIWAJI UNIVERSITY   (India)

Author keywords

Liquid liquid extraction; Matrix effects; Method validation; Nevirapine; Pharmacokinetic; Protein precipitation; Solid phase extraction

Indexed keywords

ENALAPRIL; NEVIRAPINE;

ADULT; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 79952325361     PISSN: None     EISSN: 09750851     Source Type: Journal    
DOI: 10.4172/jbb.1000052     Document Type: Article

References (22)

1. Mirochnick M, Clarke DF, Dorenbaum A (2000) Nevirapine: pharmacokinetic considerations in children and pregnant women. Clin. Pharmacokinet 39: 281-293.
2. Jackson JB, Musoke P, Fleming T, Guay LA, Bagenda D, et al. (2003) Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 362: 859-868.
3. Taha TE, Kumwenda NI, Gibbins A (2003) Short postexposure prophylaxis in newborn babies to reduce mother-to-child transmission of HIV-1: NVAZ randomised clinical trial. Lancet 362: 1171-1777.
4. Stringer JSA, Rouse DJ, Sinkala M, Marseille EA, Vermund SH, et al. (2003) Nevirapine to prevent mother-to-child transmission of HIV-1 among women of unknown serostatus. Lancet 362: 1850-1853.
5. Jourdain G, Ngo-Giang-Huong N, La Coeur S, Bowonwatanuwong C, Kantipong P, et al. (2004) Intrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-Based Antiretroviral Therapy. N Engl J Med. 351: 229-240.
6. Gibbs JE, Gaffen Z, Thomas SA (2006) Nevirapine Uptake into the Central Nervous System of the Guinea Pig: An in Situ Brain Perfusion Study JPET 317: 746-751.
7. Pav JW, Rowland LS, Korpalski DJ (1999) HPLC-UV method for the quantitation of nevirapine in biological matrices following solid phase extraction. J Pharm Biomed Anal 20: 91-98.
8. Marchei E, Valvo L, Pacifici R, Pellegrini M, Tossini G, Zuccaro P (2002) Simultaneous determination of zidovudine and nevirapine in human plasma by RP-LC. J. Pharm Biomed Anal. 29: 1081-1088.
9. Silverthorn CF, Parsons TL (2005) A validated new method for nevirapine quantitation in human plasma via high-performance liquid chromatography. Biomed. Chromatogr. 20: 23-27.
10. Kabra V, Agrahari V, Karthikeyan C, Trivedi P (2009) Simultaneous quantitative determination of zidovudine and nevirapine in human plasma using isocratic, reverse phase high performance liquid chromatography Trop J Pharm Res. 8: 79-86.
11. van Heeswijk RP, Hoetelmans RM, Meenhorst PL, Mulder JW, Beijnen JH (1998) Rapid determination of nevirapine in human plasma by ion-pair reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 25: 395-399.
12. Ramachandran G, Hemanthkumar AK, Kumaraswami V, Swaminathan S (2006) A simple and rapid liquid chromatography method for simultaneous determination of zidovudine and nevirapine in plasma. J Chromatogr B 843: 339-344.
13. Venkata Kumar CH, Ananth Kumar D, Rao JVLNS (2010) A New Validated RPHPLC Method for the Determination of Nevirapine in Human Plasma. E-Journal of Chemistry 7: 821-826.
14. Kappelhoff BS, Rosing H, Huitema ADR, Beijnen JH (2003) Simple and rapid method for the simultaneous determination of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma using liquid chromatography. J Chromatogr B 792: 353-362.
15. Zhou Li, Ding C, Qinghua G, Zhou Z, Zhi X, et al. (2010) Simultaneous determination of lamivudine, stavudine and nevirapine in human plasma by LC-MS/MS and its application to pharmacokinetic study in clinic. Biomed Chromatogr.24: 926-934.
16. Notari S, Mancone C, Alonzi T, Tripodi M, Narciso P, Ascenzi P (2008) Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF. J Chromatogr B 863: 249-257.
17. Chi J, Jayewardene AL, Stone JA, Aweeka FT (2003) An LC-MS-MS method for the determination of nevirapine, a non-nucleoside reverse transcriptase inhibitor, in human plasma J Pharm Biomed Anal 31: 953-959.
18. Laurito TL, Santagada V, Caliendo G, Oliveira CH, Barrientos-Astigarraga RE, et al.(2002) Nevirapine quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Application to bioequivalence study J Mass Spectrom 37: 434-441.
19. Ghosh C, Singh RP, Inamdar S, Mote M, Chakraborty BS (2009) Sensitive, Selective, Precise and Accurate LC-MS Method for Determination of Clonidine in Human Plasma Chromatographia, 69: 1227-1232.
20. Ghosh C, Jha V, Ahir R, Shah S, Shinde CP, Chakraborty BS (2010) A rapid and most sensitive liquid chromatography/tandem mass spectrometrymethod for simultaneous determination of alverine and its major metabolite, para hydroxy alverine, in human plasma: application to a pharmacokinetic and bioequivalence study Drug Test Anal 2: 284-291.
21. Ghosh C, Shinde CP, Chakraborty BS (2010) Ionization Polarity as a Cause of Matrix Effects, its Removal and Estimation in ESI-LC-MS/MS Bio-analysis J Anal Bioanal Techniques 1: 106.
22. Guidance for Industry, Bioanalytical Method Validation Food and Drug Administration, Center for Drug Evaluation and Research (CDER), 2001.