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Volumn 2, Issue 6, 2010, Pages 284-291
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A rapid and most sensitive liquid chromatography/tandemmass spectrometry method for simultaneous determination of alverine and its major metabolite, para hydroxy alverine, in human plasma: Application to a pharmacokinetic and bioequivalence study
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Author keywords
Alverine; Bio equivalence; LC MS MS; Matrix effects; Para hydroxyl alverine
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Indexed keywords
ELECTROSPRAY IONIZATION;
LIQUID CHROMATOGRAPHY;
PHARMACOKINETICS;
PHASE SEPARATION;
PLASMA (HUMAN);
POSITIVE IONS;
ALVERINE;
BIO-EQUIVALENCE;
HUMAN PLASMAS;
LC-MS-MS;
LC.MS/MS;
MATRICES EFFECT;
PARA HYDROXY ALVERINE;
PARA HYDROXYL ALVERINE;
PHARMACOKINETIC STUDIES;
METABOLITES;
ALVERINE CITRATE;
4-HYDROXYALVERINE;
ALVERINE;
MICROCAPSULE;
PHENOL DERIVATIVE;
PROPYLAMINE;
ACCURACY;
ADULT;
ARTICLE;
BIOEQUIVALENCE;
CALIBRATION;
CLINICAL TRIAL;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
CROSSOVER PROCEDURE;
DRUG BLOOD LEVEL;
DRUG DETERMINATION;
DRUG METABOLISM;
ELECTROSPRAY MASS SPECTROMETRY;
HUMAN;
HUMAN EXPERIMENT;
LIQUID CHROMATOGRAPHY;
MALE;
NORMAL HUMAN;
PRIORITY JOURNAL;
RANDOMIZED CONTROLLED TRIAL;
SINGLE DRUG DOSE;
SOLID PHASE EXTRACTION;
TANDEM MASS SPECTROMETRY;
BLOOD;
COMPARATIVE STUDY;
MICROCAPSULE;
ORAL DRUG ADMINISTRATION;
PROCEDURES;
REPRODUCIBILITY;
THERAPEUTIC EQUIVALENCE;
VALIDATION STUDY;
ADMINISTRATION, ORAL;
CAPSULES;
CHROMATOGRAPHY, LIQUID;
CROSS-OVER STUDIES;
HUMANS;
MALE;
PHENOLS;
PROPYLAMINES;
REPRODUCIBILITY OF RESULTS;
SOLID PHASE EXTRACTION;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
TANDEM MASS SPECTROMETRY;
THERAPEUTIC EQUIVALENCY;
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EID: 77954026493
PISSN: 19427603
EISSN: 19427611
Source Type: Journal
DOI: 10.1002/dta.130 Document Type: Article |
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Times cited : (12)
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References (7)
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