All-trans retinoic acid induces TLR-5 expression and cell differentiation and promotes flagellin-mediated cell functions in human THP-1 cells

Immunology Letters

Volumn 136, Issue 1, 2011, Pages 97-107

  Cho, Hae Yun ^a   Choi, Eun Kyoung ^a   Lee, Soo Woon ^b   Kim, Ki Hyung ^b   Park, Sang Jun ^b   Lee, Chae Kwan ^a   Lee, Soo Woong ^a  

^a Inje University   (South Korea)

^b Inje University College of Medicine   (South Korea)

Author keywords

Allostimulatory capacity; ATRA; Flagellin; Human TLR 5; NF B; THP 1 cells

Indexed keywords

B7 ANTIGEN; CD11B ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; FLAGELLIN; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE RESPONSE; DENDRITIC CELL; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

CELL DIFFERENTIATION; CELL LINE; FLAGELLIN; GENE EXPRESSION REGULATION; HUMANS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RECEPTORS, RETINOIC ACID; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; TRETINOIN;

EID: 79952316827     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2011.01.001     Document Type: Article

References (34)

1. Gudas L.J., Sporn M.B., Roberts A.B. Biology, chemistry, and medicine. The retinoids: cellular biology and biochemistry of the retinoids 1994, 443-520. Raven Press, New York. M.B. Sporn, A.B. Roberts, D.S. Goodman (Eds.).
2. Mathew J.S., Sharma R.P. Effect of all-trans-retinoic acid on cytokine production in a murine macrophage cell line. Int J Immunopharmacol 2000, 22(9):693-706.
3. Witcher M., Ross D.T., Rousseau C., Deluca L., Miller W.H. Synergy between all-trans retinoic acid and tumor necrosis factor pathways in acute leukemia cells. Blood 2003, 102(1):237-245.
4. Allende L.M., Corell A., Madrono A., Gongora R., Rodriguez-Gallego C., Lopez-Goyanes A., et al. Retinol (vitamin A) is a cofactor in CD3-induced human T-lymphocyte activation. Immunology 1997, 90(3):388-396.
5. Israel H., Odziemiec C., Ballow M. The effects of retinoic acid on immunoglobulin synthesis by human cord blood mononuclear cells. Clin Immunol Immunopathol 1991, 59(3):417-425.
6. Wang X., Allen C., Ballow M. Retinoic acid enhances the production of IL-10 while reducing the synthesis of IL-12 and TNF-alpha from LPS-stimulated monocytes/macrophages. J Clin Immunol 2007, 27(2):193-200.
7. Mohty M., Morbelli S., Isnardon D., Sainty D., Arnoulet C., Gaugler B., et al. All-trans retinoic acid skews monocyte differentiation into interleukin-12-secreting dendritic-like cells. Br J Haematol 2003, 122:829-836.
8. Cantorna M.T., Nashold F.E., Hayes C.E. In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J Immunol 1994, 152:1515-1522.
9. Racke M.K., Burnett D., Pak S.H., Albert P.S., Cannella B., Raine C.S., et al. Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. J Immunol 1995, 154:450-458.
10. Zou F., Liu Y., Liu L., Wu K., Wei W., Zhu Y., et al. Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARalpha/RXRalpha heterodimer to a novel retinoic acid response element in the promoter. Biochem Biophys Res Commun 2007, 355(2):494-500.
11. Heyman R.A., Mangelsdorf D.J., Dyck J.A., Stein R.B., Eichele G., Evans R.M., et al. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992, 68:397-406.
12. Liu P.T., Krutzik S.R., Kim J., Modlin R.L. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function. J Immunol 2005, 174(5):2467-2470.
13. Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., et al. The innate immune response to bacterial flagellin is mediated by toll-like receptor 5. Nature 2001, 410(6832):1099-1103.
14. Means T.K., Hayashi F., Smith K.D., Aderem A., Luster A.D. The toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol 2003, 170(10):5165-5175.
15. Cario E., Podolsky D.K. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000, 68:7010-7017.
16. Uematsu S., Fujimoto K., Jang M.H., Yang B.G., Jung Y.J., Nishiyama M., et al. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing toll-like receptor 5. Nat Immunol 2008, 9(7):769-776.
17. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schütz G., Umesono K., et al. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
18. Kiningham K.K., Cardozo Z.A., Cook C., Cole M.P., Stewart J.C., Tassone M., et al. All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-κB. Spitz Free Radic Biol Med 2008, 44:1610-1616.
19. Hemmi H., Breitman T.R. Induction of functional differentiation of a human monocytic leukemia cell line (THP-1) by retinoic acid and cholera toxin. Jpn J Cancer Res 1985, 76(5):345-351.
20. Chen Q., Ross A.C. Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res 2004, 297(1):68-81.
21. Saxena R.K., Vallyathan V., Lewis D.M. Evidence for lipopolysaccharide-induced differentiation of RAW264.7 murine macrophage cell line into dendritic like cells. J Biosci 2003, 28:129-134.
22. Lee Y.N., Lee H.Y., Kang H.K., Kwak J.Y., Bae Y.S. Phosphatidic acid positively regulates LPS-induced differentiation of RAW264.7 murine macrophage cell line into dendritic-like cells. Biochem Biophys Res Commun 2004, 318(4):839-845.
23. Puig-Kröger A., Serrano-Gómez D., Caparrós E., Domínguez-Soto A., Relloso M., Colmenares M., et al. Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages. J Biol Chem 2004, 279(24):25680-25688.
24. Cantorna M.T., Nashold F.E., Hayes C.E., Vitamin A deficiency results in a priming environment conducive for Th1 cell development. Eur J Immunol 1995, 25:1673-1679.
25. Wang T., Niwa S., Bouda K., Matsuura S., Homma T., Shudo K., et al. The effect of Am-80, one of retinoids derivatives on experimental allergic encephalomyelitis in rats. Life Sci 2000, 67:1869-1879.
26. Manicassamy S., Pulendran B. Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages. Semin Immunol 2009, 21(1):22-27.
27. Manna S.K., Aggarwal B.B. All-trans-retinoic acid up-regulates TNF receptors and potentiates TNF-induced activation of nuclear factors-κB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene 1999, 19:2110-2119.
28. Harant H., de Martin R., Andrew P.J., Foglar E., Dittrich C., Lindley I.J. Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and tumor necrosis factor-α involves the transcription factor NF-κB. J Biol Chem 1996, 271(43):26954-26961.
29. Kollmar R., Sukow K.A., Sponagle S.K., Farnham P.J. Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter. J Biol Chem 1994, 269(3):2252-2257.
30. Chen X., Azizkhan J.C., Lee D.C. The binding of transcription factor Sp1 to multiple sites is required for maximal expression from the rat transforming growth factor alpha promoter. Oncogene 1992, 7(9):1805-1815.
31. Bastien J., Rochette-Egly C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 2004, 328:1-16.
32. Ma W., Gee K., Lim W., Chambers K., Angel J.B., Kozlowski M., et al. Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors. J Immunol 2004, 172:318-330.
33. Merlin T., Gumenscheimer M., Galanos C., Freudenberg M.A. TNF-alpha hyper-responses to Gram-negative and Gram-positive bacteria in Propionibacterium acnes primed or Salmonella typhimurium infected mice. J Endotoxin Res 2001, 7(2):157-163.
34. Ciacci-Woolwine F., Blomfield I.C., Richardson S.H., Mizel S.B. Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell line. Infect Immun 1998, 66(3 (Mar)):1127-1134.