Isocitrate dehydrogenase mutations may be a protective mechanism in glioma patients

Medical Hypotheses

Volumn 76, Issue 4, 2011, Pages 602-603

  Zhu, Jian ^a,b   Zuo, Jianling ^a   Xu, Qinian ^a   Wang, Xiuyun ^a   Wang, Zhong ^a   Zhou, Dai ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b Yancheng City No1 People's Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE (NADP); ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE ISOENZYME; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER SURVIVAL; CARCINOGENESIS; CATALYSIS; CELL DEATH; CELL METABOLISM; CELL PROTECTION; ENZYME ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GLIOMA; HUMAN; NONHUMAN; PROTEIN FUNCTION; TUMOR CELL; WILD TYPE;

BRAIN NEOPLASMS; CATALYSIS; GENETIC PREDISPOSITION TO DISEASE; GLIOMA; HUMANS; ISOCITRATE DEHYDROGENASE; MUTATION;

EID: 79952313734     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.01.011     Document Type: Article

References (16)

1. Louis D.N., Ohgaki H., Wiestler O.D., Cavenee W.K., Burger P.C., Jouvet A., et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007, 114:97-109.
2. Wen P.Y., Kesari S. Malignant gliomas in adults. N Engl J Med 2008, 359:492-507.
3. Yan H., Parsons D.W., Jin G., McLendon R., Rasheed B.A., Yuan W., et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009, 360:765-773.
4. Winkler B.S., DeSantis N., Solomon F. Multiple NADPH-producing pathways control glutathione (GSH) content in retina. Exp Eye Res 1986, 43:829-847.
5. +-dependent isocitrate dehydrogenase. J Biol Chem 2001, 276:16168-16176.
6. Lee S.M., Koh H.J., Park D.C., Song B.J., Huh T.L., Park J.W. Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. Free Radic Biol Med 2002, 32:1185-1196.
7. Kim S.Y., Park J.W. Cellular defense against singlet oxygen-induced oxidative damage by cytosolic NADP+-dependent isocitrate dehydrogenase. Free Radic Res 2003, 37:309-316.
8. Henke B., Girzalsky W., Berteaux-Lecellier V., Erdmann R. IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids. J Biol Chem 1998, 273:3702-3711.
9. van Roermund C.W., Hettema E.H., Kal A.J., Van den Berg M., Tabak H.F., Wanders R.J. Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions. EMBO J 1998, 17:677-687.
10. Geisbrecht B.V., Gould S.J. The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. J Biol Chem 1999, 274:30527-30533.
11. Minard K.I., McAlister-Henn L. Dependence of peroxisomal beta-oxidation on cytosolic sources of NADPH. J Biol Chem 1999, 274:3402-3406.
12. Yoshihara T., Hamamoto T., Munakata R., Tajiri R., Ohsumi M., Yokota S. Localization of cytosolic NADP-dependent isocitrate dehydrogenase in the peroxisomes of rat liver cells: biochemical and immunocytochemical studies. J Histochem Cytochem 2001, 49:1123-1131.
13. Sun L., Sun T.T., Lavker R.M. Identification of a cytosolic NADP+-dependent isocitrate dehydrogenase that is preferentially expressed in bovine corneal epithelium. A corneal epithelial crystallin. J Biol Chem 1999, 274:17334-17341.
14. Zhao S., Lin Y., Xu W., Jiang W., Zha Z., Wang P., et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 2009, 324:261-265.
15. Dang L., White D.W., Gross S., Bennett B.D., Bittinger M.A., Driggers E.M., et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009, 462:739-744.
16. Aghili M., Zahedi F., Rafiee E. Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review. J Neurooncol 2009, 91:233-236.