The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Liu, Shujun ^a,b   Madiai, Francesca ^a   Hackshaw, Kevin V ^a   Allen, Carl E ^c   Carl, Joseph ^c   Huschart, Emily ^c   Karanfilov, Chris ^c   Litsky, Alan ^d   Hickey, Christopher J ^b,c   Marcucci, Guido ^a,b   Huja, Sarandeep ^c   Agarwal, Sudha ^c   Yu, Jianhua ^b   Caligiuri, Michael A ^b   Wu, Lai Chu ^a,b,c  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d The Ohio State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; COLONY STIMULATING FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C JUN; PROTEIN ZAS3; SMALL INTERFERING RNA; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR; ZAS3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BONE REMODELING; BONE STRUCTURE; CELL COUNT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE RESISTANCE; DRUG TARGETING; EX VIVO STUDY; FEMALE; FRACTURE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY SEQUENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; AGING; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; BONE DEVELOPMENT; BONE MARROW CELL; CELL FRACTIONATION; CELL LINE; CHEMISTRY; DRUG EFFECT; FEMUR; METABOLISM; MOLECULAR GENETICS; OSTEOCLAST; PATHOLOGY; PROTEIN BINDING; PROTEIN TRANSPORT;

MUS;

AGING; AMINO ACID SEQUENCE; ANIMALS; BONE MARROW CELLS; CELL COUNT; CELL LINE; DNA-BINDING PROTEINS; FEMUR; FRACTURES, BONE; GENE EXPRESSION REGULATION; GENE SILENCING; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; OSTEOCLASTS; OSTEOGENESIS; PROTEIN BINDING; PROTEIN TRANSPORT; RANK LIGAND; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 79952308718     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017161     Document Type: Article

References (36)

1. Wu LC, (2002) ZAS: C2H2 zinc finger proteins involved in growth and development. Gene Expr 10: 137-152.
2. Allen CE, Wu LC, (2004) ZAS zinc finger proteins: the other kappa-B-binding protein family. In: Iuchi Shiro, Kuldell Natalie, editors. Zinc finger proteins from atomic contact to cellular function Georgetown, Texas Landes Bioscience pp. 233-261.
3. Wu LC, Mak CH, Dear N, Boehm T, Foroni L, et al. (1993) Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res 21: 5067-5073.
4. Hjelmsoe I, Allen CE, Cohn MA, Tulchinsky EM, Wu LC, (2000) The kappa B and V(D)J Recombination Signal Sequence Binding Protein KRC Regulates Transcription of the Mouse Metastasis-associated Gene S100A4/mts1. J Biol Chem 275: 913-920.
5. Fan CM, Maniatis T, (1990) A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes Dev 4: 29-42.
6. Yang X, Li J, Qin H, Yang H, Li J, et al. (2005) Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. J Biol Chem 280: 18710-18716.
7. Dorflinger U, Pscherer A, Moser M, Rummele P, Schule R, et al. (1999) Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. Mol Cell Biol 19: 3736-3747.
8. Makino R, Akiyama K, Yasuda J, Mashiyama S, Honda S, et al. (1994) Cloning and characterization of a c-myc intron binding protein (MIBP1). Nucleic Acids Res 22: 5679-5685.
9. Jin W, Takagi T, Kanesashi SN, Kurahashi T, Nomura T, et al. (2006) Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins. Dev Cell 10: 461-471.
10. Shukla A, Malik M, Cataisson C, Ho Y, Friesen T, et al. (2009) TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3. Nat Cell Biol 11: 777-784.
11. Yakovich AJ, Jiang B, Allen CE, Du J, Wu LC, et al. (2011) ZAS3 accentuates transforming growth factor beta signaling in epithelial cells. Cell Signal 23: 105-113.
12. Oukka M, Kim ST, Lugo G, Sun J, Wu LC, et al. (2002) A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2. Mol Cell 9: 121-131.
13. Oukka M, Wein MN, Glimcher LH, (2004) Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells. J Exp Med 199: 15-24.
14. Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, et al. (2006) Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 312: 1223-1227.
15. Allen CE, Richards J, Muthusamy N, Auer H, Liu Y, et al. (2007) Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development. Gene Expr 14: 83-100.
16. Saita Y, Takagi T, Kitahara K, Usui M, Ezura Y, et al. (2007) Lack of schnurri-2 expression associates with reduced bone remodeling and osteopenia. J Biol Chem 282: 12907-15.
17. Jones DC, Schweitzer MN, Wein M, Sigrist K, Takagi T, et al. (2010) Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3. Proc Natl Acad Sci U S A 107: 8254-8258.
18. David JP, Sabapathy K, Hoffmann O, Idarraga MH, Wagner EF, (2002) JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and-independent mechanisms. J Cell Sci 115: 4317-4325.
19. Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, et al. (2004) Critical roles of c-Jun signaling in regulation of NFAT family and sRANKL-regulated osteoclast differentiation. J Clin Invest 114: 475-484.
20. Novack DV, Teitelbaum SL, (2008) The osteoclast: friend or foe? Annu Rev Pathol 3: 457-484.
21. Matsumoto M, Sudo T, Saito T, Osada H, Tsujimoto M, (2000) Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (sRANKL). J Biol Chem 275: 31155-31161.
22. Nakabayashi Y, Wevers HW, Cooke TD, Griffin M, (1994) Bone strength and histomorphometry of the distal femur. J Arthroplasty 9: 307-315.
23. Hu R, Sharma SM, Bronisz A, Srinivasan R, Sankar U, et al. (2007) Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Mol Cell Biol 27: 4018-4027.
24. Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 13: 1015-1024.
25. Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, et al. (2002) Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418: 443-447.
26. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, et al. (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20: 345-357.
27. Liang J, Lints R, Foehr ML, Tokarz R, Yu L, et al. (2003) The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling. Development 130: 6453-6464.
28. Dai H, Hogan C, Gopalakrishnan B, Torres-Vazquez J, Nguyen M, et al. (2000) The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic. Dev Biol 227: 373-387.
29. Baldridge D, Shchelochkov O, Kelley B, Lee B, (2010) Signaling pathways in human skeletal dysplasias. Annu Rev Genomics Hum Genet 11: 189-217.
30. Asagiri M, Sato K, Usami T, Ochi S, Nishina H, et al. (2005) Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 202: 1261-1269.
31. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, et al. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate sRANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3: 889-901.
32. Hirotani H, Touhy N, Woo JT, Stern PH, Clipstone NA, (2004) The calcineurin/NFAT signaling pathway regulates osteoclastogenesis in RAW 264.7 cells. J Biol Chem 279: 13984-13992.
33. Liu S, Wu LC, Pang J, Santhanam R, Schwind S, et al. (2010) Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell 17: 333-347.
34. Wu LC, Goettl VM, Madiai F, Hackshaw KV, Hussain SR, (2006) Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury. BMC Neurosci 7: 4.
35. Liu S, Liu Z, Xie Z, Pang J, Yu J, et al. (2008) Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia. Blood 111: 2364-2373.
36. Hong JW, Allen CE, Wu LC, (2003) Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif. Proc Natl Acad Sci USA 100: 12301-12306.