Reperfusion and outcomes in Penumbra vs. systemic tissue plasminogen activator clinical trials

International Journal of Stroke

Volumn 6, Issue 2, 2011, Pages 118-122

  Alexandrov, Andrei V ^a   Schellinger, Peter D ^b   Saqqur, Maher ^c   Barreto, Andrew ^d   Demchuk, Andrew M ^e   Ribo, Marc ^f   Rubiera, Marta ^f   Sharma, Vijay K ^g   Heliopoulos, Ioannis ^h   Alexandrov, Anne W ^a   Molina, Carlos A ^f   Tsivgoulis, Georgios ^a,h  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALGARY   (Canada)

^f HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^g NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^h DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Occlusion; Outcome; Stroke; Thrombectomy; Thrombolysis

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; BRAIN PERFUSION; CLINICAL TRIAL (TOPIC); COMPARATIVE STUDY; CONTROLLED STUDY; DEVICE; DISEASE SEVERITY; FEMALE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PRIORITY JOURNAL; RANKIN SCALE; RECANALIZATION; REVASCULARIZATION; SYMPTOM; SYSTEMIC THERAPY; TREATMENT OUTCOME;

AGED; CLINICAL TRIALS AS TOPIC; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; RECOVERY OF FUNCTION; REPERFUSION; RETROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 79952303019     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/j.1747-4949.2010.00559.x     Document Type: Article

References (21)

1. Penumbra Pivotal Stroke Trial Investigators. The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 2009; 40:2761-8.
2. Alexandrov AV, Molina CA, Grotta JC et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 2004; 351:2170-8.
3. Molina CA, Barreto AD, Tsivgoulis G et al. Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial. Ann Neurol 2009; 66:28-38.
4. Tsivgoulis G, Culp WC, Alexandrov AV. Ultrasound enhanced thrombolysis in acute arterial ischemia. Ultrasonics 2008; 48:303-11.
5. Demchuk AM, Burgin WS, Christou I et al. Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator. Stroke 2001; 32:89-93.
6. Burgin WS, Malkoff M, Felberg RA et al. Transcranial Doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke. Stroke 2000; 31:1128-32.
7. Alexandrov AV, Burgin WS, Demchuk AM, El-Mitwalli A, Grotta JC. Speed of intracranial clot lysis with intravenous TPA therapy: sonographic classification and short term improvement. Circulation 2001; 103:2897-902.
8. Chernyshev OY, Garami Z, Calleja S et al. The yield and accuracy of urgent combined carotid-transcranial ultrasound testing in acute cerebral ischemia. Stroke 2005; 36:32-7.
9. Tsivgoulis G, Sharma VK, Lao AY, Malkoff MD, Alexandrov AV. Validation of transcranial doppler with computed tomography angiography in acute cerebral ischemia. Stroke 2007; 38:1245-9.
10. Lewis JR, Sauro J. When 100% Really Isn't 100%: improving the accuracy of small-sample estimates of completion rates. JUS 2006; 1:136-50.
11. Furlan A, Higashida R, Wechsler L et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA 1999; 282:2003-11.
12. Smith WS, Sung G, Saver J et al. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 2008; 39:1205-12.
13. The IMS II Study Investigators. The Interventional Management of Stroke (IMS II) Study. Stroke 2007; 38:2127-35.
14. Alexandrov AV. Ultrasound enhancement of fibrinolysis. Stroke 2009; 40:S107-10.
15. Dinia L, Rubiera M, Ribo M et al. Reperfusion after stroke sonothrombolysis with microbubbles may predict intracranial bleeding. Neurology 2009; 73:775-780.
16. Molina CA, Montaner J, Abilleira S et al. Timing of spontaneous recanalization and risk of hemorrhagic transformation in acute cardioembolic stroke. Stroke 2001; 32:1079-84.
17. Tsivgoulis G, Saqqur M, CLOTBUST Investigators et al. Association of pretreatment blood pressure with tissue plasminogen activator-induced arterial recanalization in acute ischemic stroke. Stroke 2007; 38:961-6.
18. Molina CA, Alexandrov AV, CLOTBUST Investigators et al. Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator. Stroke 2004; 35:151-6.
19. Nogueira RG, Liebeskind DS, Multi MERCI et al. Writing Committee. Predictors of good clinical outcomes, mortality, and successful revascularization in patients with acute ischemic stroke undergoing thrombectomy: pooled analysis of the mechanical embolus removal in cerebral ischemia (MERCI) and Multi MERCI trials. Stroke 2009; 40:3777-83.
20. Hacke W, Kaste M, ECASS Investigators et al. Thrombolysis with alteplase 3 to 4·5 hours after acute ischemic stroke. N Engl J Med 2008; 359:1317-29.
21. Del Zoppo GJ, Saver JL, Jauch EC, Adams HP Jr, American Heart Association Stroke Council. Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart Association/American Stroke Association. Stroke 2009; 40:2945-8.