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European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1343-1347

Design, synthesis, and biological evaluation of novel γ-carboline ketones as anticancer agents

(8) Chen, Jing a Liu, Tao b Wu, Rui b Lou, Jianshu b Dong, Xiaowu b He, Qiaojun b Yang, Bo b Hu, Yongzhou b

a ZHEJIANG CHINESE MEDICAL UNIVERSITY (China)

b ZHEJIANG UNIVERSITY (China)

Author keywords

Carboline ketones; Anticancer; Antitubulin; Synthesis

Indexed keywords

5 ETHYL 8 (2 FLUOROBENZOYL)GAMMA CARBOLINE; 5 ETHYL 8 (3 METHOXYBENZOYL)GAMMA CARBOLINE; 5 ETHYL 8 (4 METHOXYBENZOYL)GAMMA CARBOLINE; 5 ETHYL 8 (4 METHYLSULFONYLBENZOYL)GAMMA CARBOLINE; 5 ETHYL 8 (4 NITROBENZOYL)GAMMA CARBOLINE; 8 (2 CHLOROBENZOYL) 5 ETHYL GAMMA CARBOLINE; 8 (4 BROMOBENZOYL) 2, 5 DIETHYL GAMMA CARBOLINE 3 IUM BROMIDE; 8 (4 BROMOBENZOYL) 5 ETHYL GAMMA CARBOLINE; 8 (4 CHLOROBENZOYL) 5 ETHYL GAMMA CARBOLINE; 8 BENZOYL 2, 5 DIETHYL GAMMA CARBOLINE 3 IUM BROMIDE; 8 BENZOYL 5 ETHYL GAMMA CARBOLINE; 8 BENZOYL 5 ISOPROPYL GAMMA CARBOLINE; 8 BENZOYL 5 METHYL GAMMA CARBOLINE; ANTINEOPLASTIC AGENT; GAMMA CARBOLINE KETONE DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; KETONES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 79952280836 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2011.01.057 Document Type: Article

Times cited : (18)

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