Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content

Journal of Molecular Diagnostics

Volumn 13, Issue 2, 2011, Pages 220-232

  Milbury, Coren A ^a   Chen, Clark C ^a,b   Mamon, Harvey ^a   Liu, Pingfang ^a   Santagata, Sandro ^c   Makrigiorgos, G Mike ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN P53;

ALLELE; ARTICLE; COAMPLIFICATION AT LOWER DENATURATION POLYMERASE CHAIN REACTION; CONTROLLED STUDY; DILUTION; DNA CONTENT; DNA SEQUENCE; DOWNSTREAM PROCESSING; EXON; GENE AMPLIFICATION; GENE MUTATION; GENETIC SCREENING; HIGH RESOLUTION MELTING; HUMAN; HUMAN CELL; HUMAN TISSUE; MELTING POINT; MULTIPLEX POLYMERASE CHAIN REACTION; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

EID: 79952257474     PISSN: 15251578     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmoldx.2010.10.008     Document Type: Article

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