Evaluation of hemostatic effects of Ankaferd as an alternative medicine

Alternative Medicine Review

Volumn 15, Issue 4, 2010, Pages 329-336

  Beyazit, Yavuz ^a   Kurt, Mevlut ^a   Kekilli, Murat ^a   Goker, Hakan ^b   Haznedaroglu, Ibrahim Celalettin ^b  

^a TURKIYE YUKSEK IHTISAS HOSPITAL   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

ABS; Ankaferd; Bleeding; Blood; Hemophilia; Hemophiliac; Hemorrhage; Hemorrhagic; Hemostasis; Hemostatic; Wound healing

Indexed keywords

ADRENALIN; ANKAFERD BLOOD STOPPER; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; CYCLOPHOSPHAMIDE; FIBRINOGEN; FRESH FROZEN PLASMA; HEMOSTATIC AGENT; HERBACEOUS AGENT; PREDNISOLONE; PROTHROMBIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID; UNCLASSIFIED DRUG; WOUND HEALING PROMOTING AGENT; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR; PLANT EXTRACT;

ACINETOBACTER; ALPINIA OFFICINARUM; ALTERNATIVE MEDICINE; ANGIOGENESIS; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ASPERGILLUS; BLEEDING; BLOOD CELL; CANDIDA ALBICANS; CELL PROLIFERATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; ENDOTHELIUM; ENTEROCOCCUS; ERYTHROCYTE AGGREGATION; ESCHERICHIA COLI; FRACTURE HEALING; GASTROINTESTINAL HEMORRHAGE; GLANZMANN DISEASE; GLYCYRRHIZA GLABRA; GRAPE; HEMODYNAMICS; HEMOPHILIA A; HEMOSTASIS; HEREDITARY THROMBOCYTOPENIA; HOMEOSTASIS; HUMAN; IN VITRO STUDY; KLEBSIELLA; LEUKOCYTE ACTIVATION; LEUKOCYTE AGGREGATION; LUNG CANCER; LUNG HEMORRHAGE; MUCOR; NONHUMAN; OPEN HEART SURGERY; OSSIFICATION; POSTOPERATIVE HEMORRHAGE; PSEUDOMONAS; RECTUM ULCER; REVIEW; STAPHYLOCOCCUS AUREUS; THROMBOCYTE; THROMBOCYTOPENIA; THYME; URTICA DIOICA; VON WILLEBRAND DISEASE; WOUND HEALING; ANIMAL; BLOOD CLOTTING; CHEMISTRY; GLYCYRRHIZA; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; BLOOD LOSS, SURGICAL; GLYCYRRHIZA; HEMORRHAGE; HEMOSTASIS; HEMOSTATICS; HUMANS; PLANT EXTRACTS; THYMUS PLANT; URTICA DIOICA; VITIS;

EID: 79952255538     PISSN: 10895159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. Bilgili H, Kosar A, Kurt M, et al. Haemostatic efficacy of Ankaferd Blood Stopper in a swine bleeding model. Med Princ Pract 2009;18:165-169.
2. Bilgili H, Captug O, Kosar A, et al. Oral systemic administration of Ankaferd Blood Stopper has no short-term toxicity in an in vivo rabbit experimental model. Clin Appl Thromb Hemost 2010;16:533-536.
3. Goker H, Haznedaroglu IC, Ercetin S, et al. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. J Int Med Res 2008;36:163-170. (Pubitemid 351255983)
4. Demiralp DO, Haznedaroglu IC, Akar N. Functional proteomic analysis of Ankaferd Blood Stopper. Turk J Hematol 2010;27:70-77.
5. Haznedaroglu BZ, Haznedaroglu IC, Walker SL, et al. Ultrastructural and morphological analyses of the in vitro and in vivo hemostatic effects of Ankaferd Blood Stopper. Clin Appl Thromb Hemost 2010;16:446-453.
6. Aydin S. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. J Int Med Res 2009;37:279.
7. Al B, Yildirim C, Cavdar M, et al. Effectiveness of Ankaferd Blood Stopper in the topical control of active bleeding due to cutaneous-subcutaneous incisions. Saudi Med J 2009;30:1520-1525.
8. Teker AM, Korkut AY, Gedikli O, Kahya V. Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy. Int J Pediatr Otorhinolaryngol 2009;73:1742-1745.
9. Meric Teker A, Korkut AY, Kahya V, Gedikli O. Prospective, randomized, controlled clinical trial of Ankaferd Blood Stopper in patients with acute anterior epistaxis. Eur Arch Otorhinolaryngol 2010;267:1377-1381.
10. Kurt M, Kacar S, Onal IK, et al. Ankaferd Blood Stopper as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract. Endoscopy 2008;40:E262.
11. Kurt M, Oztas E, Kuran S, et al. Tandem oral, rectal, and nasal administrations of Ankaferd Blood Stopper to control profuse bleeding leading to hemodynamic instability. Am J Emerg Med 2009;27:631.e1-2.
12. Kurt M, Akdogan M, Onal IK, et al. Endoscopic topical application of Ankaferd Blood Stopper for neoplastic gastrointestinal bleeding: a retrospective analysis. Dig Liver Dis 2010;42:196-199.
13. Kurt M, Onal I, Akdogan M, et al. Ankaferd Blood Stopper for controlling gastrointestinal bleeding due to distinct benign lesions refractory to conventional antihemorrhagic measures. Can J Gastroenterol 2010;24:380-384.
14. Ozaslan E, Purnak T, Yildiz A, Haznedaroglu IC. The effect of a new hemostatic agent for difficult cases of non-variceal gastrointestinal bleeding: Ankaferd Blood Stopper. Hepatogastroenterology 2010;57:191-194.
15. Ozaslan E, Purnak T, Yildiz A, et al. The effect of Ankaferd Blood Stopper on severe radiation colitis. Endoscopy 2009;41:E321-E322.
16. Turhan N, Kurt M, Shorbagi A, et al. Topical Ankaferd Blood Stopper administration to bleeding gastrointestinal carcinomas decreases tumor vascularization. Am J Gastroenterol 2009;104:2874-2877.
17. Arslan S, Oz B, Haznedaroglu IC, Goker H. Endobronchial application of Ankaferd Blood Stopper to control profuse lung bleeding leading to hypoxemia and hemodynamic instability. Respir Med CME 2009;2:144-146.
18. Dogan OF, Ozyurda U, Uymaz OK, et al. New anticoagulant agent for CABG surgery. Eur J Clin Invest 2008;38:341.
19. Lee SJ, Umano K, Shibamoto T, et al. Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymes vulgaris L.) and their antioxidant properties. Food Chem 2007;91:131-137. (Pubitemid 39572542)
20. Sheela ML, Ramakrishna MK, Salimath BP. Angiogenic and proliferative effects of the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra. Int Immunopharmacol 2006;6:494-498. (Pubitemid 43120464)
21. Kosar A, Cipil HS, Kaya A, et al. The efficacy of Ankaferd Blood Stopper in antithrombotic drug-induced primary and secondary hemostatic abnormalities of a rat-bleeding model. Blood Coagul Fibrinolysis 2009;20:185-190.
22. Karakaya K, Ucan HB, Tascilar O, et al. Evaluation of a new hemostatic agent Ankaferd Blood Stopper in experimental liver laceration. J Invest Surg 2009;22:201-206.
23. Cipil HS, Kosar A, Kaya A, et al. In vivo hemostatic effect of the medicinal plant extract Ankaferd Blood Stopper in rats pretreated with warfarin. Clin Appl Thromb Hemost 2009;15:270-276.
24. Huri E, Akgül T, Ayyildiz A, et al. Hemostatic role of a folkloric medicinal plant extract in a rat partial nephrectomy model: controlled experimental trial. J Urol 2009;181:2349-2354.
25. Pusateri AE, Holcomb JB, Kheirabadi BS, et al. Making sense of the preclinical literature on advanced hemostatic products. J Trauma 2006;60:674-682.
26. Ercetin S, Haznedaroglu IC, Kurt M, et al. Safety and efficacy of Ankaferd Blood Stopper in dental surgery. UHOD 2010;20:1-5
27. Bakik OS, Koroglu M, Cipil H, et al. A placebo-controlled, randomized, double-blinded, cross-over phase I clinical study to demonstrate safety of Ankaferd Blood Stopper topical usage in healthy volunteers. Int J Lab Hematol 2010;32:126-127.
28. Kurt M, Disibeyaz S, Akdogan M, et al. Endoscopic application of Ankaferd Blood Stopper as a novel experimental treatment modality for upper gastrointestinal bleeding: a case report. Am J Gastroenterol 2008;103:2156-2158.
29. Ibis M, Kurt M, Onal IK, Haznedaroglu IC. Successful management of bleeding due to solitary rectal ulcer via topical application of Ankaferd Blood Stopper. J Altern Complement Med 2008;14:1073-1074.
30. Shorbagi A, Sivri B. Successful management of a difficult case of radiation proctopathy with Ankaferd Blood Stopper: a novel indication (with video). Gastrointest Endosc 2010;72:666-667.
31. Oner A, Dogan M, Kaya A, et al. New coagulant agent (Ankaferd Blood Stopper) for open hemorrhages in hemophilia with inhibitor. Clin Appl Thromb Hemost 2009 June 14. [Epub ahead of print]
32. Canatan D, Savaş Ç, Kubulu AE, et al. RFVIIA and Ankaferd use in a hemophilia patient with inhibitor [abstract]. 34th National Congress of Hacmatology. İzmir, Turkey; 2008: Abstract B056.
33. Baykul T, Alanoglu EG, Kocer G. Use of Ankaferd Blood Stopper as a hemostatic agent; a clinical experience. J Contemp Dent Pract 2010;11:E088-E094.
34. Çalişkan Ü, Uçar Albayrak C, Acipayamli C. Stopping of bleeding after tooth extraction with Ankaferd administration in a case with TAR syndrome [abstract]. 34th National Congress of Haematology. İzmir, Turkey; 2008: Abstract B0139.
35. Çalişkan Ü, Uçar Albayrak C, Acipayamli C. Stopping of bleeding after tooth extraction and circumcision with Ankaferd administration in a case with Glanzmann thrombastenia [abstract]. 34th National Congress of Haematology. İzmir, Turkey; 2008: Abstract B0140.
36. Akkoc N, Akcelik M, Haznedaroglu I, et al. In vitro anti-bacterial activities of Ankaferd Blood Stopper. Int J Lab Hematol 2008;30:95.
37. Tasdelen Fisgin N, Tanriverdi Cayci Y, Coban AY, et al. Antimicrobial activity of plant extract Ankaferd Blood Stopper. Fitoterapia 2009;80:48-50.
38. İşler SC, Demircan S, Cakarer S, et al. Effects of folk medicinal plant extract Ankaferd Blood Stopper on early bone healing. J Appl Oral Sci 2010;18:409-414.