In vivo hemostatic effect of the medicinal plant extract ankaferd blood stopper in rats pretreated with warfarin

Clinical and Applied Thrombosis/Hemostasis

Volumn 15, Issue 3, 2009, Pages 270-276

  Cipil, Handan S ^a   Kosar, Ali ^a   Kaya, Arif ^a   Uz, Burak ^a   Haznedaroglu, Ibrahim C ^b   Goker, Hakan ^b   Ozdemir, Oktay ^c   Koroglu, Mustafa ^a   Kirazli, Serafettin ^d   Firat, Huseyin Cahit ^d  

^a FATIH UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c Yorum Konsultancy Inc   (Turkey)

^d Ankaferd Drug Inc   (Turkey)

Author keywords

Ankaferd; Bleeding; Hemostasis; In vivo; Rats; Warfarin

Indexed keywords

ANKAFERD BLOOD STOPPER; HEMOSTATIC AGENT; PLANT EXTRACT; WARFARIN;

AMPUTATION; ANIMAL; ARTICLE; BLEEDING; BLOOD; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; FEMALE; HEMOSTASIS; HINDLIMB; MALE; RAT; TIME; TOPICAL DRUG ADMINISTRATION; WISTAR RAT;

ADMINISTRATION, TOPICAL; AMPUTATION; ANIMALS; BLOOD LOSS, SURGICAL; DISEASE MODELS, ANIMAL; FEMALE; HEMORRHAGE; HEMOSTASIS; HEMOSTATICS; HINDLIMB; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; TIME FACTORS; WARFARIN;

EID: 67649973931     PISSN: 10760296     EISSN: 19382723     Source Type: Journal    
DOI: 10.1177/1076029608329578     Document Type: Article

References (15)

1. Goker H, Haznedaroglu IC, Ercetin S, et al. Haemostatic actions of the folkloric medicinal plant extract, Ankaferd blood stopper. J Int Med Res. 2008;36:163-170.
2. Kurt M, Disibeyaz S, Akdogan M, Sasmaz N, Aksu S, Haznedaroglu IC. Endoscopic application of Ankaferd Blood Stopper as a novel experimental treatment modality for upper gastrointestinal bleeding: a case report. Am J Gastroenterol. 2008;103:2156-2158.
3. Matsuda H, Ando S, Kato T, Morikawa T, Yoshikawa M. Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharideactivated macrophages and the structural requirements of diarrylheptanoids for the activity. Bioorg Med Chem. 2006;14:138-142.
4. Lee SJ, Umano K, Shibamoto T, Lee KG. Identification of volatile components in basil Ocimum basilicum L. and thyme leaves Thymus vulgaris L. and their antioxidant properties. Food Chem. 2007;91:131-137.
5. Testai L, Chericoni S, Calderone V, et al. Cardiovascular effects of Urtica dioica L. Urticaceae roots extracts: in vitro and in vivo pharmacological studies. J Ethnopharmacol. 2002;81:105-109.
6. Sheela ML, Ramakrishna MK, Salimath BP. Angiogenic and proliferative effects if the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra. Int Immunopharmacol. 2006;6:494-498.
7. Barka EA, Belarbi A, Hachet C, Nowak J, Audran JC. Enhancement of in vitro growth and resistance to gray mould of Vitis vinifera co-cultured with plant growthpromoting rhizobacteria. FEMS Microbiol Lett. 2000; 186:91-95.
8. Barka E, Gognies S, Nowak J, Audran J-C, Belarbi A. Inhibitory effect of endophyte bacteria on Botrytis cinerea and its influence to promote the grapevine growth. Biol Control. 2002;24:135-142.
9. Zhao J,Wang J, Chen Y, Agarwal R. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in themouse skin two-stageinitiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Carcinogenesis. 1999;20:1737-1745.
10. Yamakoshi J, Kataoka S, Koga T, Ariga T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 1999;142: 139-149.
11. Akkoc N, Akcelik M, Haznedaroglu I, et al. In vitro antibacterial activities of Ankaferd blood stopper. Int J Lab Hematol. 2008;30:95.
12. Dogan OF, Ozyurda U, Uymaz OK, Ercetin S, Haznedaroglu IC. New anticoagulant agent for CABG surgery. Eur J Clin Invest. 2008;38:341.
13. Kurt M, Kacar S, Onal IK, Akdogan M, Haznedaroglu IC. Ankaferd Blood Stopper1 as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract. Endoscopy. 2008.
14. Ibis M, Kurt M, Onal IK, Haznedaroglu IC. Successful management of bleeding due to solitary rectal ulcer via topical application of Ankaferd Blood Stopper1. J Altern Complement Med. 2008. IN PRESS.
15. Kurt M, Oztas E, Kuran S, Onal IK, Kekilli M, Haznedaroglu IC. Tandem oral, rectal, and nasal administrations of Ankaferd Blood Stopper to control profuse bleedings leading to hemodynamic instability. Am J Emergency Med. 2008. IN PRESS.