PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice

Journal of Neuroimmunology

Volumn 232, Issue 1-2, 2011, Pages 207-208

  Bill, Ruben ^a   Döring, Axinia ^a   Deutsch, Urban ^a   Engelhardt, Britta ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Backcrossing; EAE; Gene targeted mice; Modulatory genes; PSGL 1

Indexed keywords

ALPHA4 INTEGRIN; ALPHA4 INTEGRIN ANTIBODY; P SELECTIN GLYCOPROTEIN LIGAND 1; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CD4+ T LYMPHOCYTE; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; DNA POLYMORPHISM; ENDOTHELIUM CELL; GENE FREQUENCY; HAPLOTYPE; IMMUNOCOMPETENT CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE;

ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT;

EID: 79952248690     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.10.008     Document Type: Article

References (15)

1. Bahbouhi B., Berthelot L., Pettre S., Michel L., Wiertlewski S., Weksler B., Romero I.A., Miller F., Couraud P.O., Brouard S., Laplaud D.A., Soulillou J.P. Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line. J. Leukoc. Biol. 2009, 86:1049-1063.
2. Bartholomaus I., Kawakami N., Odoardi F., Schlager C., Miljkovic D., Ellwart J.W., Klinkert W.E., Flugel-Koch C., Issekutz T.B., Wekerle H., Flugel A. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009, 462:94-98.
3. Battistini L., Piccio L., Rossi B., Bach S., Galgani S., Gasperini C., Ottoboni L., Ciabini D., Caramia M.D., Bernardi G., Laudanna C., Scarpini E., McEver R.P., Butcher E.C., Borsellino G., Constantin G. CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Blood 2003, 101:4775-4782.
4. Coisne C., Mao W., Engelhardt B. Cutting edge: natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. J. Immunol. 2009, 182:5909-5913.
5. Deshpande P., King I.L., Segal B.M. IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination. J. Neuroimmunol. 2006, 173:35-44.
6. Doring A., Wild M., Vestweber D., Deutsch U., Engelhardt B. E- and P-Selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J. Immunol. 2007, 179:8470-8479.
7. Engelhardt B. The blood-central nervous system barriers actively control immune cell entry into the central nervous system. Curr. Pharm. Des. 2008, 14:1555-1565.
8. Engelhardt B., Kappos L. Natalizumab: targeting alpha4-integrins in multiple sclerosis. Neurodegener. Dis. 2008, 5:16-22.
9. Engelhardt B., Vestweber D., Hallmann R., Schulz M. E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis. Blood 1997, 90:4459-4472.
10. Engelhardt B., Kempe B., Merfeld-Clauss S., Laschinger M., Furie B., Wild M.K., Vestweber D. P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J. Immunol. 2005, 175:1267-1275.
11. Kerfoot S.M., Norman M.U., Lapointe B.M., Bonder C.S., Zbytnuik L., Kubes P. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J. Immunol. 2006, 176:6225-6234.
12. Osmers I., Bullard D.C., Barnum S.R. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2005, 166:193-196.
13. Scalabrini D., Galimberti D., Fenoglio C., Comi C., De Riz M., Venturelli E., Castelli L., Piccio L., Ronzoni M., Lovati C., Mariani C., Monaco F., Bresolin N., Scarpini E. P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis. Neurosci. Lett. 2005, 388:149-152.
14. Uboldi C., Doring A., Alt C., Estess P., Siegelman M., Engelhardt B. L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis. Eur. J. Immunol. 2008, 38:2156-2167.
15. Yang J., Galipeau J., Kozak C.A., Furie B.C., Furie B. Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor. Blood 1996, 87:4176-4186.