Establishment of an aging model of Sca-1+ hematopoietic stem cell and studies on its relative biological mechanisms

In Vitro Cellular and Developmental Biology - Animal

Volumn 47, Issue 2, 2011, Pages 149-156

  Zhou, Yue ^a   Yang, Bing ^a   Yao, Xin ^a   Wang, Yaping ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Aging; Biological mechanisms; Hematopoietic stem cell; Model in vitro

Indexed keywords

BETA GALACTOSIDASE; LY ANTIGEN; LY6A PROTEIN, MOUSE; MEMBRANE PROTEIN; TELOMERASE;

AGING; ANIMAL; ANIMAL MODEL; ARTICLE; CELL AGING; CELL CYCLE; CYTOLOGY; GENETICS; HEMATOPOIETIC STEM CELL; MOUSE; PHYSIOLOGY;

AGING; ANIMALS; ANTIGENS, LY; BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE; HEMATOPOIETIC STEM CELLS; MEMBRANE PROTEINS; MICE; MODELS, ANIMAL; TELOMERASE;

MURINAE;

EID: 79952241804     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-010-9372-5     Document Type: Article

References (17)

1. M Aimin Y Wang AB Stephen, et al. 2003 Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and independent mechanisms Experimental Hematology 31 1348 1356 10.1016/j.exphem.2003.08.014 (Pubitemid 37510042)
2. INK4a-mediated senescence Oncogene 28 22 2238 43 1:CAS:528:DC%2BD1MXltV2gtLk%3D 10.1038/onc.2009.94 19398954
3. I Ben-Porath RA Weinberg 2005 The signals and pathways activating cellular senescence Int J Biochem Cell Biol. 37 961 976 1:CAS:528: DC%2BD2MXhvVGjs7c%3D 10.1016/j.biocel.2004.10.013 15743671 (Pubitemid 40311739)
4. D Brad G de Haan 2008 Hematopoietic stem cell aging and self-renewal Cell Tissue Res 331 1 91 101 10.1007/s00441-007-0529-9 (Pubitemid 50003499)
5. R Gazit H Weissman DJ Rossi 2008 Hematopoietic stem cells and the aging hematopoietic system Semin Hematol 45 4 218 24 10.1053/j.seminhematol.2008.07. 010 18809091
6. INK4a Nature 443 421 6 1:CAS:528:DC%2BD28XhtVSns7fE 16957735 (Pubitemid 44477274)
7. INK4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress Blood 106 827 832 10.1182/blood-2004-06-2242 (Pubitemid 41076421)
8. D Melissa M Lynette MC Stuart, et al. 2007 The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging Blood 109 1736 1742 10.1182/blood-2006-03-010413 (Pubitemid 46239609)
9. CA Richard BM Gregg DP Ronald, et al. 2003 Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation Blood 102 517 520 10.1182/blood-2002-07-2334 (Pubitemid 36841969)
10. DJ Rossi D Bryder JM Zahn, et al. 2005 Cell alterations underlie hematopoietic stem cell aging Proc Natl Acad Sci MSA 102 9194 9199 1:CAS:528:DC%2BD2MXlvF2ku7o%3D 10.1073/pnas.0503280102 (Pubitemid 40923540)
11. DJ Rossi B David IL Weissman 2007 Hematopoietic stem cell aging: mechanism and consequence Exp Gerontol 42 5 385 90 1:CAS:528: DC%2BD2sXkt1akurc%3D 10.1016/j.exger.2006.11.019 17275237 (Pubitemid 46561181)
12. N Shinichi I Hitoshi M Hiroyuki 2009 Hematopoietic stem cell aging is associated with functional decline and delayed cell cycle progression Biochem Bioph Res Co 383 210 215 10.1016/j.bbrc.2009.03.153
13. Y Wang AS Bradley CL Amanda, et al. 2006 Total body irradiation selectively induces murine hematopoietic stem cell senescence Blood 107 358 366 1:CAS:528:DC%2BD28XhsVGksA%3D%3D 10.1182/blood-2005-04-1418 16150936 (Pubitemid 43053564)
14. Wang Y. P.; et al. Hematopoietic stem cell biology and research methods. Beijing Science Press; 2007: 348-349.
15. Wang Y. P.; et al. Stem cell aging and diseases. Beijing Science Press; 2009: 1-22.
16. Yu Hui Y Yuan H Shen, et al. 2006 Hematopoietic stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners Blood 3 1200 1206 (Pubitemid 43156324)
17. Y Zhou YP Wang 2007 Studies on hematopoietic stem cell aging and related mechanisms Prog Anat Sci 13 4 385 387 1:CAS:528:DC%2BD1cXjs1CjtL4%3D