The nuclear-factor κB pathway is activated in pterygium

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 1, 2011, Pages 230-236

  Siak, Jay Jyh Kuen ^a   Ng, See Liang ^b   Seet, Li Fong ^a   Beuerman, Roger W ^a,c,d   Tong, Louis ^a,b  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DNA; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GELATINASE A; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR FACTOR KAPPA B 2; PROTEIN P100; PROTEIN P50; PROTEIN P52; RANTES; STROMELYSIN; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CCL2 PROTEIN, HUMAN; CCL5 PROTEIN, HUMAN; CXCL5 PROTEIN, HUMAN; I KAPPA B; MATRIX METALLOPROTEINASE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ARTICLE; CELL NUCLEUS; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; PTERYGIUM; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CULTURE; CONJUNCTIVA; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINE CCL5; CHEMOKINE CXCL5; CONJUNCTIVA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; I-KAPPA B PROTEINS; MATRIX METALLOPROTEINASES; NF-KAPPA B; PHOSPHORYLATION; PTERYGIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952214500     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5735     Document Type: Article

References (34)

1. Gazzard G, Saw SM, Farook M, et al. Pterygium in Indonesia: prevalence, severity and risk factors. Br J Ophthalmol. 2002;86: 1341-1346.
2. Lee AJ, Lee J, Saw SM, et al. Prevalence and risk factors associated with dry eye symptoms: a population based study in Indonesia. Br J Ophthalmol. 2002;86:1347-1351.
3. Di Girolamo N, McCluskey P, Lloyd A, Coroneo MT, Wakefield D. Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells. Invest Ophthalmol Vis Sci. 2000;41: 671-679.
4. Moran DJ, Hollows FC. Pterygium and ultraviolet radiation: a positive correlation. Br J Ophthalmol. 1984;68:343-346.
5. Detels R, Dhir SP. Pterygium: a geographical study. Arch Ophthalmol. 1967;78:485-491.
6. Lekhanont K, Rojanaporn D, Chuck RS, Vongthongsri A. Prevalence of dry eye in Bangkok, Thailand. Cornea. 2006;25:1162-1167.
7. Pahl HL. Activators and target genes of Rel/NF-kappa B transcription factors. Oncogene. 1999;18:6853-6866.
8. Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 1998;16:225-260.
9. Hohmann HP, Remy R Poschl B, van Loon AP. Tumor necrosis factors-alpha and -beta bind to the same two types of tumor necrosis factor receptors and maximally activate the transcription factor NF-kappa B at low receptor occupancy and within minutes after receptor binding. J Biol Chem. 1990;265:15183-15188.
10. Mordmuller B, Krappmann D, Esen M, Wegener E, Scheidereit C. Lymphotoxin and lipopolysaccharide induce NF-kappa B-p52 generation by a co-translational mechanism. EMBO Rep. 2003;4:82-87.
11. Ghosh S, Hayden MS. New regulators of NF-kappa B in inflammation. Nat Rev Immunol. 2008;8:837-848.
12. Derudder E, Dejardin E, Pritchard LL, Green DR, Korner M, Baud V. RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100.JBiol Chem. 2003;278:23278-23284.
13. Basak S, Hoffmann A. Crosstalk via the NF-kappa B signaling system. Cytokine Growth Factor Rev. 2008;19:187-197.
14. Cameron ME. Histology of pterygium: an electron microscopic study. Br J Ophthalmol. 1983;67:604-608.
15. Fan C-M, Maniatis T. Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway. Nature. 1991;354:395-398.
16. Abeyama K, Eng W, Jester JV, et al. A role for NF-kappa B-depen-dent gene transactivation in sunburn. J Clin Invest. 2000;105: 1751-1759.
17. Kennedy M, Kim KH, Harten B, et al. Ultraviolet irradiation induces the production of multiple cytokines by human corneal cells. Invest Ophthalmol Vis Sci. 1997;38:2483-2491
18. Massingale ML, Li X, Vallabhajosyula M, Chen D, Wei Y, Asbell PA. Analysis of inflammatory cytokines in the tears of dry eye patients. Cornea. 2009;28:1023-1027.
19. Kria L, Ohira A, Amemiya T. Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium. Acta Histochem. 1996;98:195-201.
20. Pinkerton OD, Hokama Y, Shigemura LA. Immunologic basis for the pathogenesis of pterygium. Am J Ophthalmol. 1984;98:225-228.
21. Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP. Stabilization of snail by NF-kappa B is required for inflammation-induced cell migration and invasion. Cancer Cell. 2009;15:416-428.
22. Julien S, Puig I, Caretti E, et al. Activation of NF-kappa B by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene. 2007;26:7445-7456.
23. Kato N, Shimmura S, Kawakita T, et al. β-Catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Invest Ophthalmol Vis Sci. 2007;48:1511-1517.
24. Basak S, Kim H, Kearns JD, et al. A fourth Ikappa B protein within the NF-kappa B signaling module. Cell. 2007;128:369-381.
25. Solomon A, Li DQ, Lee SB, Tseng SC. Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines. Invest Ophthalmol Vis Sci. 2000;41:2154-2163.
26. Li DQ, Lee SB, Gunja-Smith Z, et al. Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts. Arch Ophthalmol. 2001;119:71-80.
27. Di Girolamo N, Wakefield D, Coroneo MT. Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head. Invest Ophthalmol Vis Sci. 2000;41: 4142-4149.
28. De Siervi A, De Luca P, Moiola C, et al. Identification of new Rel/NFkappa B regulatory networks by focused genome location analysis. Cell Cycle. 2009;8:2093-2100.
29. Ferri N, Garton KJ, Raines EW. An NF-kappa B-dependent tran-scriptional program is required for collagen remodeling by human smooth muscle cells. J Biol Chem. 2003;278:19757-19764.
30. Connelly L, Robinson-Benion C, Chont M, et al. A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. J Biol Chem. 2007;282:10028-10035.
31. Park MH, Ahn BH, Hong YK, Min Do S. Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappa B/Sp1-mediated signaling pathways. Carcinogenesis. 2009; 30:356-365.
32. Lee SJ, Bae SS, Kim KH, et al. High glucose enhances MMP-2 production in adventitial fibroblasts via Akt1-dependent NF-kap-paB pathway. FEBS Lett. 2007;581:4189-4194.
33. Han Z, Boyle DL, Manning AM, Firestein GS. AP-1 and NF-kappa B regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity. 1998;28:197-208.
34. Bond M, Chase AJ, Baker AH, Newby AC. Inhibition of transcription factor NF-kappa B reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res. 2001;50:556-565.