Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: Influence of proliferation

British Journal of Cancer

Volumn 86, Issue 4, 2002, Pages 517-523

  Awwad, H K ^a   Lotayef, M ^a   Shouman, T ^a   Begg, A C ^b   Wilson, G ^d   Bentzen, S M ^d   Abd El Moneim, H ^a   Eissa, S ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c Gray Cancer Institute   (United Kingdom)

^d NONE

Author keywords

Accelerated hyperfractionation; Head and neck cancer; Postoperative radiotherapy; Predictive factors; Proliferation kinetics

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CONTROL; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EDEMA; FEMALE; FIBROSIS; FRACTIONATION; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME; XEROSTOMIA;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; FEMALE; FIBROSIS; HEAD AND NECK NEOPLASMS; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE CARE; RADIATION INJURIES; RADIOTHERAPY DOSAGE; XEROSTOMIA;

EID: 0037065971     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600119     Document Type: Article

References (24)

1. Dangers of using optimal cutpoints in the evaluation of prognostic factors
2. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head and neck cancer
3. Accelerated versus conventional fractionation in the postoperative irradiation of locally advanced head and neck cancer: Influence of tumour proliferation
4. The value of pretreatment cell kinetic parameters as predictors for radiotherapy outcome in head and neck cancer: A multicenter analysis
5. A method to measure duration of DNA synthesis and the potential doubling time from a single sample
6. Tumour proliferation assessed by a combined histological and flow cytometric analysis: Implications for therapy in squamous cell carcinoma in the head and neck
7. In vivo measurement of the potential doubling time by flowcytometry in oropharyngeal cancer treated by conventional radiotherapy
8. In vivo cell kinetics in head and neck squamous cell carcinoma predicts local control and helps guide radiotherapy regimen
9. Treatment-time-dependence models of early and delayed radiation injury in rat small intestine
10. Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the Institute Gustave Roussy experience
11. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves locoregional control in the radiotherapy of advanced head and neck cancers: Results of the EORTC 22851 randomized trial
12. Lack of predictive value of potential doubling time and iododeoxyuridine labelling index in radiotherapy of squamous cell carcinoma of the head and neck
13. Tumor cell kinetics, local tumor control and accelerated radiotherapy; a preliminary report
14. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: First report of a prospective randomized study
15. Applying radiobiological principles to combined modality treatment of head and neck cancer - The time factor
16. Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: A randomized multicentric trial
17. Time-dose factors in radiotherapy: A review of human data
18. Wound healing following radiation therapy: A review
19. Postoperative accelerated radiotherapy in high-risk squamous cell carcinoma of the head and neck: Long-term results of a prospective trial
20. Limitations of bromodeoxyuridine technique for measurement of tumor proliferation
21. Measurement of cell kinetics in human tumours in vivo using bromodeoxyuridine incorporation and flow cytometry
22. The hazard of accelerated tumor clonogen repopulation during radiotherapy
23. Predictive value of potential doubling time in head and neck cancer patients treated by conventional radiotherapy