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Volumn 682, Issue , 2011, Pages 217-234

Cytokinesis-Block Micronucleus Cytome Assay in Lymphocytes

Author keywords

Cytome; Cytotoxicity; DNA damage; Lymphocyte; Micronucleus; Nuclear bud; Nucleoplasmic bridge

Indexed keywords

CYTOCHALASIN B;

EID: 79952200867     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-60327-409-8_16     Document Type: Chapter
Times cited : (77)

References (26)
  • 1
    • 0015623107 scopus 로고
    • A rapid in vivo test for chromosomal damage
    • Heddle, J. A. (1973) A rapid in vivo test for chromosomal damage. Mutat Res 18, 187–90.
    • (1973) Mutat Res , vol.18 , pp. 187-190
    • Heddle, J.A.1
  • 2
    • 0016437314 scopus 로고
    • The micronucleus test
    • Schmid, W. (1975) The micronucleus test. Mutat Res 31, 9–15.
    • (1975) Mutat Res , vol.31 , pp. 9-15
    • Schmid, W.1
  • 3
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech, M. (2000) The in vitro micronucleus technique. Mutat Res 455, 81–95.
    • (2000) Mutat Res , vol.455 , pp. 81-95
    • Fenech, M.1
  • 4
    • 0022589981 scopus 로고
    • Cytokinesis-block micronucleus method in human lymphocytes: Effect of in vivo ageing and low dose X-irradiation
    • Fenech, M., and Morley, A. A. (1986) Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat Res 161, 193–8.
    • (1986) Mutat Res , vol.161 , pp. 193-198
    • Fenech, M.1    Morley, A.A.2
  • 5
    • 0014212637 scopus 로고
    • Effects of cytochalasins on mammalian cells
    • Carter, S. B. (1967) Effects of cytochalasins on mammalian cells. Nature 213, 261–4.
    • (1967) Nature , vol.213 , pp. 261-264
    • Carter, S.B.1
  • 6
    • 0030840634 scopus 로고    scopus 로고
    • The advantages and disadvantages of the cytokinesis-block micronucleus method
    • Fenech, M. (1997) The advantages and disadvantages of the cytokinesis-block micronucleus method. Mutat Res 392, 11–8.
    • (1997) Mutat Res , vol.392 , pp. 11-18
    • Fenech, M.1
  • 7
    • 0033858808 scopus 로고    scopus 로고
    • A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division
    • Fenech, M. (2000) A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division. Mutagenesis 15, 329–36.
    • (2000) Mutagenesis , vol.15 , pp. 329-336
    • Fenech, M.1
  • 8
    • 0022203364 scopus 로고
    • Solutions to the kinetic problem in the micronucleus assay
    • Fenech, M., and Morley, A. (1985) Solutions to the kinetic problem in the micronucleus assay. Cytobios 43, 233–46.
    • (1985) Cytobios , vol.43 , pp. 233-246
    • Fenech, M.1    Morley, A.2
  • 9
    • 0021987630 scopus 로고
    • Measurement of micronuclei in lymphocytes
    • Fenech, M., and Morley, A. A. (1985) Measurement of micronuclei in lymphocytes. Mutat Res 147, 29–36.
    • (1985) Mutat Res , vol.147 , pp. 29-36
    • Fenech, M.1    Morley, A.A.2
  • 10
    • 0023679003 scopus 로고
    • Immunofluorescent staining of kinetochores in micronuclei: A new assay for the detection of aneuploidy
    • Degrassi, F., and Tanzarella, C. (1988) Immunofluorescent staining of kinetochores in micronuclei: a new assay for the detection of aneuploidy. Mutat Res 203, 339–45.
    • (1988) Mutat Res , vol.203 , pp. 339-345
    • Degrassi, F.1    Tanzarella, C.2
  • 11
    • 0023789221 scopus 로고
    • The identification of micronucleated chromosomes: A possible assay for aneuploidy
    • Thomson, E. J., and Perry, P. E. (1988) The identification of micronucleated chromosomes: a possible assay for aneuploidy. Mutagenesis 3, 415–8.
    • (1988) Mutagenesis , vol.3 , pp. 415-418
    • Thomson, E.J.1    Perry, P.E.2
  • 12
    • 0027244839 scopus 로고
    • The use of fluorescence in situ hybridization for the detection of aneugens in cytokinesis-blocked mouse splenocytes
    • Farooqi, Z., Darroudi, F., and Natarajan, A. T. (1993) The use of fluorescence in situ hybridization for the detection of aneugens in cytokinesis-blocked mouse splenocytes. Mutagenesis 8, 329–34.
    • (1993) Mutagenesis , vol.8 , pp. 329-334
    • Farooqi, Z.1    Darroudi, F.2    Natarajan, A.T.3
  • 13
    • 0030851298 scopus 로고    scopus 로고
    • A critical evaluation of centromeric labeling to distinguish micronuclei induced by chromosomal loss and breakage in vitro
    • Schuler, M., Rupa, D. S., and Eastmond, D. A. (1997) A critical evaluation of centromeric labeling to distinguish micronuclei induced by chromosomal loss and breakage in vitro. Mutat Res 392, 81–95.
    • (1997) Mutat Res , vol.392 , pp. 81-95
    • Schuler, M.1    Rupa, D.S.2    Eastmond, D.A.3
  • 14
    • 0037112246 scopus 로고    scopus 로고
    • Chromosomal biomarkers of genomic instability relevant to cancer
    • Fenech, M. (2002) Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov Today 7, 1128–37.
    • (2002) Drug Discov Today , vol.7 , pp. 1128-1137
    • Fenech, M.1
  • 16
    • 0037340936 scopus 로고    scopus 로고
    • Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay
    • Thomas, P., Umegaki, K., and Fenech, M. (2003) Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay. Mutagenesis 18, 187–94.
    • (2003) Mutagenesis , vol.18 , pp. 187-194
    • Thomas, P.1    Umegaki, K.2    Fenech, M.3
  • 17
    • 0034892585 scopus 로고    scopus 로고
    • Micronuclei and chromatid buds are the result of related genotoxic events
    • Serrano-Garcia, L., and Montero-Montoya, R. (2001) Micronuclei and chromatid buds are the result of related genotoxic events. Environ Mol Mutagen 38, 38–45.
    • (2001) Environ Mol Mutagen , vol.38 , pp. 38-45
    • Serrano-Garcia, L.1    Montero-Montoya, R.2
  • 18
    • 0034646365 scopus 로고    scopus 로고
    • Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei
    • Shimizu, N., Shimura, T., and Tanaka, T. (2000) Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei. Mutat Res 448, 81–90.
    • (2000) Mutat Res , vol.448 , pp. 81-90
    • Shimizu, N.1    Shimura, T.2    Tanaka, T.3
  • 19
    • 0030774496 scopus 로고    scopus 로고
    • A more comprehensive application of the micronucleus technique for biomonitoring of genetic damage rates in human populations – experiences from the Chernobyl catastrophe
    • Fenech, M., Perepetskaya, G., and Mikhalevich, L. (1997) A more comprehensive application of the micronucleus technique for biomonitoring of genetic damage rates in human populations – experiences from the Chernobyl catastrophe. Environ Mol Mutagen 30, 112–8.
    • (1997) Environ Mol Mutagen , vol.30 , pp. 112-118
    • Fenech, M.1    Perepetskaya, G.2    Mikhalevich, L.3
  • 20
    • 0035170551 scopus 로고    scopus 로고
    • Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes
    • Kirsch-Volders, M., and Fenech, M. (2001) Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis 16, 51–8.
    • (2001) Mutagenesis , vol.16 , pp. 51-58
    • Kirsch-Volders, M.1    Fenech, M.2
  • 21
    • 33747335092 scopus 로고    scopus 로고
    • Cytokinesis-block micronucleus assay evolves into a “cytome” assay of chromosomal instability, mitotic dysfunction and cell death
    • Fenech, M. (2006) Cytokinesis-block micronucleus assay evolves into a “cytome” assay of chromosomal instability, mitotic dysfunction and cell death. Mutat Res 600, 58–66.
    • (2006) Mutat Res , vol.600 , pp. 58-66
    • Fenech, M.1
  • 22
    • 0024461337 scopus 로고
    • Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody
    • Eastmond, D. A., and Tucker, J. D. (1989) Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environ Mol Mutagen 13, 34–43.
    • (1989) Environ Mol Mutagen , vol.13 , pp. 34-43
    • Eastmond, D.A.1    Tucker, J.D.2
  • 23
    • 0032774223 scopus 로고    scopus 로고
    • Effect of blood storage on radiation-induced micronuclei in human lymphocytes
    • Lee, T. K., O’Brien, K., Eaves, G. S., Christie, K. I., and Varga, L. (1999) Effect of blood storage on radiation-induced micronuclei in human lymphocytes. Mutat Res 444, 201–6.
    • (1999) Mutat Res , vol.444 , pp. 201-206
    • Lee, T.K.1    O’Brien, K.2    Eaves, G.S.3    Christie, K.I.4    Varga, L.5
  • 24
    • 0034063801 scopus 로고    scopus 로고
    • The use of cryopreserved lymphocytes in assessing inter-individual radiosensitivity with the micronucleus assay
    • Burrill, W., Levine, E. L., Hindocha, P., Roberts, S. A., and Scott, D. (2000) The use of cryopreserved lymphocytes in assessing inter-individual radiosensitivity with the micronucleus assay. Int J Radiat Biol 76, 375–82.
    • (2000) Int J Radiat Biol , vol.76 , pp. 375-382
    • Burrill, W.1    Levine, E.L.2    Hindocha, P.3    Roberts, S.A.4    Scott, D.5
  • 25
    • 0028980552 scopus 로고
    • Extended-term cultures of human T-lymphocytes: A practical alternative to primary human lymphocytes for use in genotox-icity testing
    • O’Donovan, M. R., Freemantle, M. R., Hull, G., Bell, D. A., Arlett, C. F., and Cole, J. (1995) Extended-term cultures of human T-lymphocytes: a practical alternative to primary human lymphocytes for use in genotox-icity testing. Mutagenesis 10, 189–201.
    • (1995) Mutagenesis , vol.10 , pp. 189-201
    • O’Donovan, M.R.1    Freemantle, M.R.2    Hull, G.3    Bell, D.A.4    Arlett, C.F.5    Cole, J.6
  • 26
    • 0037427878 scopus 로고    scopus 로고
    • HUMN project: Detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures
    • Fenech, M., Chang, W. P., Kirsch-Volders, M., Holland, N., Bonassi, S., and Zeiger, E. (2003) HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat Res 534, 65–75.
    • (2003) Mutat Res , vol.534 , pp. 65-75
    • Fenech, M.1    Chang, W.P.2    Kirsch-Volders, M.3    Holland, N.4    Bonassi, S.5    Zeiger, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.