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1
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30344456444
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New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases
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Aronoff DM, Oates JA, Boutaud O. New insights into the mechanism of action of acetaminophen: its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases. Clin Pharmacol Ther 2006; 79:9-19. A review of the mechanisms of action of paracetamol with special reference to its central effect.
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Aronoff, D.M.1
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COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression
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Chandrasekharan NV, Dai H, Roos KL, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A 2002; 99:13926-13931.
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Chandrasekharan, N.V.1
Dai, H.2
Roos, K.L.3
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3
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27744529775
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Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: Evidence for intron 1 retention
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Qin N, Zhang SP, Reitz TL, et al. Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J Pharmacol Exp Ther 2005; 315:1298-1305.
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Qin, N.1
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Orally administered paracetamol does not act locally in the rat formalin test: Evidence for a supraspinal, serotonin-dependent antinociceptive mechanism
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Bonnefont J, Alloui A, Chapuy E, et al. Orally administered paracetamol does not act locally in the rat formalin test: evidence for a supraspinal, serotonin-dependent antinociceptive mechanism. Anesthesiology 2003; 99:976-981.
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Bonnefont, J.1
Alloui, A.2
Chapuy, E.3
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6
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Onset of acetaminophen analgesia: Comparison of oral and intravenous routes after third molar surgery
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Moller PL, Sindet-Pedersen S, Petersen CT, et al. Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. Br J Anaesth 2005; 94:642-648.
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Moller, P.L.1
Sindet-Pedersen, S.2
Petersen, C.T.3
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7
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18144412033
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Onset of acetaminophen analgesia: Comparison of oral and intravenous routes after third molar surgery
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Moller PL, Sindet-Pedersen S, Petersen CT, et al. Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. Br J Anaesth 2005; 94:642-648.
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Br J Anaesth
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Moller, P.L.1
Sindet-Pedersen, S.2
Petersen, C.T.3
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8
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0031936920
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Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex
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Piguet V, Desmeules J, Dayer P. Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex. Eur J Clin Pharmacol 1998; 53:321-324.
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Piguet, V.1
Desmeules, J.2
Dayer, P.3
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9
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33645236953
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Analgesic efficacy and safety of intravenous paracetamol (acetaminophen) administered as a 2 g starting dose following third molar surgery
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Juhl GI, Norholt SE, Tonnesen E, et al. Analgesic efficacy and safety of intravenous paracetamol (acetaminophen) administered as a 2 g starting dose following third molar surgery. Eur J Pain 2006; 10:371-377. This study demonstrates that a 2-g starting dose of paracetamol provides better pain relief than a 1-g dose after third molar extraction.
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Eur J Pain
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Juhl, G.I.1
Norholt, S.E.2
Tonnesen, E.3
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10
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0028598427
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Subtleties of managing acetaminophen poisoning
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Rose SR. Subtleties of managing acetaminophen poisoning. Am J Hosp Pharm 1994; 51:3065-3068.
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Rose, S.R.1
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11
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16244388240
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Efficacy and safety of single and repeated administration of 1 g intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery
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Sinatra RS, Jahr JS, Reynolds LW, et al. Efficacy and safety of single and repeated administration of 1 g intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology 2005; 102:822-831.
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Sinatra, R.S.1
Jahr, J.S.2
Reynolds, L.W.3
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12
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32644474169
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Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study
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Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42:1364-1372.
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Hepatology
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Larson, A.M.1
Polson, J.2
Fontana, R.J.3
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13
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15244346051
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Paracetamol: An haemorrhagic risk factor in patients on warfarin
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Mahe I, Bertrand N, Drouet L, et al. Paracetamol: an haemorrhagic risk factor in patients on warfarin. Br J Clin Pharmacol 2005; 59:371-374. In a prospective double-blind, crossover, placebo-controlled study, 11 patients on stable warfarin therapy underwent in random order two 14-day regimens of paracetamol 4 g/day or placebo. Paracetamol at 4 g/day induces a significant increase in INR.
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Br J Clin Pharmacol
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Mahe, I.1
Bertrand, N.2
Drouet, L.3
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15
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26244468910
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Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers
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Munsterhjelm E, Munsterhjelm NM, Niemi TT, et al. Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers. Anesthesiology 2005; 103:712-717. Thirteen healthy volunteers were given placebo or 15, 22.5, or 30 mg/kg intravenous paracetamol in a double-blind, crossover study. Platelet function assessed by photometric aggregometry and by measuring release of thromboxane B2 was transiently and dose-dependently depressed after paracetamol infusion.
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Anesthesiology
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Munsterhjelm, E.1
Munsterhjelm, N.M.2
Niemi, T.T.3
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17
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19744371559
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Predicting postoperative analgesia outcomes: NNT league tables or procedure-specific evidence?
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Gray A, Kehlet H, Bonnet F, Rawal N. Predicting postoperative analgesia outcomes: NNT league tables or procedure-specific evidence? Br J Anaesth 2005; 94:710-714. Numbers-needed-to-treat data with paracetamol are reviewed in relation to the magnitude of surgical injury. Paracetamol was less effective for pain relief after orthopaedic procedures than after dental procedures. The relative risk ratio for more than 50% pain relief was greater after dental surgery than after orthopaedic surgery. The analgesic effect of paracetamol depends on the surgical procedure.
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Br J Anaesth
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Gray, A.1
Kehlet, H.2
Bonnet, F.3
Rawal, N.4
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18
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32944464344
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Synergism between paracetamol and non steroidal anti-inflammatory drugs in experimental acute pain
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Miranda HF, Puig MM, Prieto JC, et al. Synergism between paracetamol and non steroidal anti-inflammatory drugs in experimental acute pain. Pain 2006; 121:22-28. Synergism is determined by isobolographic analysis in mice.
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Pain
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Miranda, H.F.1
Puig, M.M.2
Prieto, J.C.3
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19
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0036172325
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Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: A qualitative review
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Hyllested M, Jones S, Pedersen JL, Kehlet H. Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 2002; 88:199-214.
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Hyllested, M.1
Jones, S.2
Pedersen, J.L.3
Kehlet, H.4
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20
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18244391224
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Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia
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Romsing J, Moiniche S, Dahl JB. Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia. Br J Anaesth 2002; 88:215-226.
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Romsing, J.1
Moiniche, S.2
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Propacetamol and ketoprofen after thyroidectomy
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Fourcade O, Sanchez P, Kern D, et al. Propacetamol and ketoprofen after thyroidectomy. Eur J Anaesthesiol 2005; 22:373-377.
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Fourcade, O.1
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25844474416
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A randomized, placebo-controlled study of rofecoxib with paracetamol in early posttonsillectomy pain in adults
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Naesh O, Niles A, Gilbert JG, et al. A randomized, placebo-controlled study of rofecoxib with paracetamol in early posttonsillectomy pain in adults. Eur J Anaesthesiol 2005; 22:768-773.
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Niles, A.2
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23
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0036137467
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Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children
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Pickering AE, Bridge HS, Nolan J, et al. Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children. Br J Anaesth 2002; 88:72-77.
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Pickering, A.E.1
Bridge, H.S.2
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24
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0035381323
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Tramadol and acetaminophen tablets for dental pain
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Medve RA, Wang J, Karim R. Tramadol and acetaminophen tablets for dental pain. Anesth Prog 2001; 48:79-81.
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Anesth Prog
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Wang, J.2
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25
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2442505407
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A double-blind placebo-controlled comparison of tramadol/acetaminophen and tramadol in patients with postoperative dental pain
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Fricke JR Jr, Hewitt DJ, Jordan DM, et al. A double-blind placebo-controlled comparison of tramadol/acetaminophen and tramadol in patients with postoperative dental pain. Pain 2004; 109:250-257.
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Fricke Jr., J.R.1
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Jordan, D.M.3
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1642297391
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Combination tramadol plus acetaminophen for postsurgical pain
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CAPSS-115 Study Group
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Smith AB, Ravikumar TS, Kamin M, et al. CAPSS-115 Study Group. Combination tramadol plus acetaminophen for postsurgical pain. Am J Surg 2004; 187:521-527.
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Smith, A.B.1
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17044413340
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Effects of acetaminophen on morphine sideeffects and consumption after major surgery: Meta-analysis of randomized controlled trials
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Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine sideeffects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth 2005; 94:505-513. The opioid-sparing effect of paracetamol is limited to 8mg of morphine over 24 hours. Consequently, this meta-analysis failed to demonstrate that paracetamol significantly reduced the incidence of side effects induced by morphine.
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Br J Anaesth
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Remy, C.1
Marret, E.2
Bonnet, F.3
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28
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19744372517
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Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: Metaanalysis of randomized controlled trials
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Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: metaanalysis of randomized controlled trials. Anesthesiology 2005; 102:1249-1260. A review of the literature found that the combination of NSAIDs with PCA morphine allows a significant reduction in the incidence of sedation, nausea, and vomiting induced by morphine.
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Anesthesiology
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Marret, E.1
Kurdi, O.2
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Bonnet, F.4
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29
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28044437747
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Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials
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Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 2005; 103:1296-1304.
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Elia, N.1
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Tramer, M.R.3
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30
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Analgesic efficacy of diclofenac in combination with morphine and paracetamol after mastectomy and immediate breast reconstruction
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Legeby M, Sandelin K, Wickman M, Olofsson C. Analgesic efficacy of diclofenac in combination with morphine and paracetamol after mastectomy and immediate breast reconstruction. Acta Anaesthesiol Scand 2005; 49:1360-1366.
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Legeby, M.1
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