Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 9-10, 2011, Pages 605-609

  Jensen, Berit Packert ^a   Vella Brincat, Jane Winifred Ann ^b   Begg, Evan James ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

Cinnarizine; Cyclizine; Human; LC MS MS; Norcyclizine; Plasma

Indexed keywords

CINNARIZINE; CYCLIZINE; HUMAN; LC-MS/MS; NORCYCLIZINE;

ACETONITRILE; CHEMICAL ANALYSIS; ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUIDS; MASS SPECTROMETRY; METHANOL; PLASMA (HUMAN); PLASMAS; STANDARDS;

LIQUID CHROMATOGRAPHY;

CYCLIZINE; NORCYCLIZINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIQUID CHROMATOGRAPHY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; QUALITY CONTROL;

CHROMATOGRAPHY, LIQUID; CINNARIZINE; CLINICAL TRIALS AS TOPIC; CYCLIZINE; HUMANS; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 79952195573     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.01.021     Document Type: Article

References (13)

1. Martindale: The Complete Drug Reference 2009, Pharmaceutical Press, London. S.C. Sweetman (Ed.).
2. Walker R.B., Kanfer I. Eur. J. Pharm. Sci. 1996, 4:301.
3. Kuntzman R., Klutch A., Tsai I., Burns J.J. J. Pharmacol. Exp. Ther. 1965, 149:29.
4. Luo H., Hawes E.M., McKay G., Korchinski E.D., Midha K.K. Xenobiotica 1991, 21:1281.
5. Dumasia M.C., Grainger L., Houghton E. Xenobiotica 2002, 32:795.
6. Dumasia M.C. Xenobiotica 2002, 32:809.
7. Walker R.B., Kanfer I. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 1995, 672:172.
8. Walker R., Kanfer I. Chromatographia 1987, 24:287.
9. Bioanalytical Separations 2003, Elsevier, Amsterdam The Netherlands.
10. Mohammadi A., Kanfer I., Sewram V., Walker R.B. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2005, 824:148.
11. Gergov M., Robson J.N., Ojanpera I., Heinonen O.P., Vuori E. Forensic Sci. Int. 2001, 121:108.
12. Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services, US FDA Center for Drug Development and Research, USA, (2001).
13. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Anal. Chem. 2003, 75:3019.