Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 5, 2011, Pages 1658-1665

  Lopez, Sergio ^a   Margison, Geoffrey P ^b   Stanley McElhinney, R ^a   Cordeiro, Alessandra ^a   McMurry, T Brian H ^a   Rozas, Isabel ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

5 Nitropyrimidine; DNA repair; Docking; MGMT; PaTrin2

Indexed keywords

5 NITROPYRIMIDINE; DNA; DNA METHYLTRANSFERASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PYRIMIDINE DERIVATIVE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DNA BINDING; DNA REPAIR; DRUG SYNTHESIS; ENZYME INACTIVATION; HUMAN; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; IC 50; SYNTHESIS;

COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PYRIMIDINES;

EID: 79952183207     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.038     Document Type: Article

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