Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 300, Issue 3, 2011, Pages

  Lingis, Melissa ^a   Richards, Elaine M ^a   Keller Wood, Maureen ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Adrenocorticotropic hormone; Aldosterone; Canrenoate; Cortisol; Pregnancy

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; CANRENOIC ACID; CORTICOTROPIN; HYDROCORTISONE; MINERALOCORTICOID RECEPTOR; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; EWE; FEMALE; HIPPOCAMPUS; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEGATIVE FEEDBACK; NONHUMAN; POTASSIUM BLOOD LEVEL; PREGNANCY; PRIORITY JOURNAL;

ADRENOCORTICOTROPIC HORMONE; ALDOSTERONE ANTAGONISTS; ANIMALS; BLOOD PRESSURE; BLOOD VOLUME; CANRENOATE POTASSIUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMATOCRIT; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MINERALOCORTICOIDS; PITUITARY-ADRENAL SYSTEM; PREGNANCY; PREGNANCY, ANIMAL; PROGESTERONE; RECEPTORS, MINERALOCORTICOID; SHEEP; WATER-ELECTROLYTE BALANCE;

EID: 79952142761     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00560.2010     Document Type: Article

References (44)

1. Arvat E, Maccagno B, Giordano R, Pellegrino M, Broglio F, Gianotti L, Maccario M, Camanni F, Ghigo E. Mineralocorticoid receptor blockade by canrenoate increases both spontaneous and stimulated adrenal function in humans. J Clin Endocrinol Metab 86: 3176-3181, 2001. (Pubitemid 32673484)
2. Atkinson HC, Wood SA, Castrique ES, Kershaw YM, Wiles CC, Lightman SL. Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor. Am J Physiol Endocrinol Metab 294: E1011-E1022, 2008.
3. Bell ME, Wood CE, Keller-Wood M. Influence of reproductive state on pituitary-adrenal activity in the ewe. Domest Anim Endocrinol 8: 245-254, 1991.
4. Berardelli R, Karamouzis I, Marinazzo E, Prats E, Picu A, Giordano R, Ghigo E, Arvat E. Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitaryadrenal axis in humans. Eur J Endocrinol 162: 1067-1074, 2010.
5. Bradbury MJ, Akana SF, Cascio CS, Levin N, Jacobson L, Dallman MF. Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain. J Steroid Biochem Mol Biol 40: 133-142, 1991.
6. Bumke-Vogt C, Bähr V, Diederich S, Herrmann SM, Anagnostopoulos I, Oelkers W, Quinkler M. Expression of the progesterone receptor and progesterone-metabolising enzymes in the female and male human kidney. J Endocrinol 175: 349-364, 2002. (Pubitemid 35414382)
7. Carey MP, Deterd CH, de Koning J, Helmerhorst F, de Kloet ER. The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat. J Endocrinol 144: 311-321, 1995.
8. Carr BR, Parker CR, Madden JD, MacDonald PC, Porter JC. Maternal adrenocorticotropin and cortisol relationships throughout human pregnancy. Am J Obstet Gynecol 139: 416-422, 1981. (Pubitemid 11191259)
9. Castren M, Patchev VK, Almeida OF, Holsboer F, Trapp T, Castren E. Regulation of rat mineralocorticoid receptor expression in neurons by progesterone. Endocrinology 136: 3800-3806, 1995.
10. Churchill S, Bengele HH, Melby JC, Alexander EA. Role of aldosterone in sodium retention of pregnancy in the rat. Am J Physiol Regul Integr Comp Physiol 240: R175-R181, 1981. (Pubitemid 11139528)
11. Deuschle M, Weber B, Colla M, Muller M, Kniest A, Heuser I. Mineralocorticoid receptor also modulates basal activity of hypothalamuspituitary-adrenocortical system in humans. Neuroendocrinology 68: 355-360, 1998. (Pubitemid 28526313)
12. Gomez-Sanchez EP. Brain mineralocorticoid receptors: orchestrators of hypertension and end-organ disease. Curr Opin Nephrol Hypertens 13: 191-196, 2004. (Pubitemid 38373141)
13. Grottoli S, Giordano R, Maccagno B, Pellegrino M, Ghigo E, Arvat E. The stimulatory effect of canrenoate, a mineralocorticoid antagonist, on the activity of the hypothalamus-pituitary-adrenal axis is abolished by alprazolam, a benzodiazepine, in humans. J Clin Endocrinol Metab 87: 4616-4620, 2002.
14. Hellal-Levy C, Fagart J, Souque A, Rafestin-Oblin ME. Mechanistic aspects of mineralocorticoid receptor activation. Kidney Int 57: 1250-1255, 2000. (Pubitemid 30207874)
15. Herman JP, Cullinan WE. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci 20: 78-84, 1997. (Pubitemid 27050702)
16. Herman JP, Mueller NK. Role of the ventral subiculum in stress integration. Behav Brain Res 174: 215-224, 2006. (Pubitemid 44585078)
17. Heuser I, Deuschle M, Weber B, Stalla GK, Holsboer F. Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactone. Psychoneuroendocrinology 25: 513-518, 2000. (Pubitemid 30249195)
18. Jacobson L, Sapolsky R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev 12: 118-134, 1991.
19. Jensen E, Wood C, Keller-Wood M. The normal increase in adrenal secretion during pregnancy contributes to maternal volume expansion and fetal homeostasis. J Soc Gynecol Investig 9: 362-371, 2002. (Pubitemid 35351340)
20. Jensen E, Wood CE, Keller-Wood M. Chronic alterations in ovine maternal corticosteroid levels influence uterine blood flow and placental and fetal growth. Am J Physiol Regul Integr Comp Physiol 288: R54-R61, 2005. (Pubitemid 40023911)
21. Jensen E, Wood CE, Keller-Wood M. Alterations in maternal corticosteroid levels influence fetal urine and lung liquid production. J Soc Gynecol Investig 10: 480-489, 2003. (Pubitemid 37510007)
22. Kalman BA, Spencer RL. Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain. Endocrinology 143: 4184-4195, 2002. (Pubitemid 35239548)
23. Keller-Wood M. Inhibition of stimulated and basal ACTH by cortisol during ovine pregnancy. Am J Physiol Regul Integr Comp Physiol 271: R130-R136, 1996.
24. Keller-Wood ME, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endocr Rev 5: 1-22, 1984.
25. Keller-Wood M, Powers MJ, Gersting JA, Ali N, Wood CE. Genomic analysis of neuroendocrine development of fetal brain-pituitary-adrenal axis in late gestation. Physiol Genomics 24: 218-224, 2006.
26. Keller-Wood M, Wood CE. Pregnancy alters cortisol feedback inhibition of stimulated ACTH: studies in adrenalectomized ewes. Am J Physiol Regul Integr Comp Physiol 280: R1790-R1798, 2001.
27. Lombes M, Binart N, Delahaye F, Baulieu EE, Rafestin-Oblin ME. Differential intracellular localization of human mineralocorticosteroid receptor on binding of agonists and antagonists. Biochem J 302: 191-197, 1994. (Pubitemid 24256354)
28. Pecins-Thompson M, Keller-Wood M. Effects of progesterone on blood pressure, plasma volume, and responses to hypotension. Am J Physiol Regul Integr Comp Physiol 272: R377-R385, 1997.
29. Quinkler M, Johanssen S, Bumke-Vogt C, Oelkers W, Bähr V, Diederich S. Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney. Mol Cell Endocrinol 171: 21-24, 2001. (Pubitemid 32098194)
30. Quinkler M, Johanssen S, Grossmann C, Bähr V, Müller M, Oelkers W, Diederich S. Progesterone metabolism in the human kidney and inhibition of 11beta-hydroxysteroid dehydrogenase type 2 by progesterone and its metabolites. J Clin Endocrinol Metab 84: 4165-4171, 1999. (Pubitemid 30644211)
31. Quinkler M, Meyer B, Oelkers W, Diederich S. Renal inactivation, mineralocorticoid generation, and 11beta-hydroxysteroid dehydrogenase inhibition ameliorate the antimineralocorticoid effect of progesterone in vivo. J Clin Endocrinol Metab 88: 3767-3772, 2003. (Pubitemid 37034526)
32. Rafestin-Oblin ME, Lombes M, Couette B, Baulieu EE. Differences between aldosterone and its antagonists in binding kinetics and ligand-induced hsp90 release from mineralocorticosteroid receptor. J Steroid Biochem Mol Biol 41: 815-821, 1992.
33. Reul JM, Gesing A, Droste S, Stec IS, Weber A, Bachmann C, Bilang-Bleuel A, Holsboer F, Linthorst AC. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. Eur J Pharmacol 405: 235-249, 2000.
34. Reul JM, van den Bosch FR, de Kloet ER. Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications. J Endocrinol 115: 459-467, 1987. (Pubitemid 18003084)
35. Richards EM, Hua Y, Keller-Wood M. Pharmacology and physiology of ovine corticosteroid receptors. Neuroendocrinology 77: 2-14, 2003. (Pubitemid 36302417)
36. Roesch DM, Keller-Wood M. Differential effects of pregnancy on mineralocorticoid and glucocorticoid receptor availability and immunore-activity in cortisol feedback sites. Neuroendocrinology 70: 55-62, 1999. (Pubitemid 29327153)
37. Rupprecht R, Reul JM, van Steensel B, Spengler D, Soder M, Berning B, Holsboer F, Damm K. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol 247: 145-154, 1993. (Pubitemid 23309995)
38. Schrier RW, Durr JA. Pregnancy: an overfill or underfill state. Am J Kidney Dis 9: 284-289, 1987. (Pubitemid 17089634)
39. Seckl JR. 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action? Front Neuroendocrinol 18: 49-99, 1997. (Pubitemid 27045165)
40. Szmuilowicz ED, Adler GK, Williams JS, Green DE, Yao TM, Hopkins PN, Seely EW. Relationship between aldosterone and progesterone in the human menstrual cycle. J Clin Endocrinol Metab 91: 3981-3987, 2006. (Pubitemid 44536873)
41. Turner BB. Influence of gonadal steroids on brain corticosteroid receptors: a minireview. Neurochem Res 22: 1375-1385, 1997. (Pubitemid 27461137)
42. Wellhoener P, Born J, Fehm HL, Dodt C. Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans. J Clin Endocrinol Metab 89: 5048-5052, 2004. (Pubitemid 39391447)
43. West C, Zhang Z, Ecker G, Masilamani SM. Increased renal α-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy. Am J Physiol Regul Integr Comp Physiol 299: R1326-R1332, 2010.
44. Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans. J Clin Endocrinol Metab 83: 3339-3345, 1998. (Pubitemid 28500982)