Renal inactivation, mineralocorticoid generation, and 11β -hydroxysteroid dehydrogenase inhibition ameliorate the antimineralocorticoid effect of progesterone in vivo

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 8, 2003, Pages 3767-3772

  Quinkler, Marcus ^a,b   Meyer, B ^a   Oelkers, W ^a   Diederich, S ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; ALDOSTERONE; ANDROSTENEDIONE; DEOXYCORTICOSTERONE; FLUDROCORTISONE; HYDROCORTISONE; MINERALOCORTICOID; MINERALOCORTICOID ANTAGONIST; POTASSIUM; PREDNISOLONE; PROGESTERONE; SODIUM; UNCLASSIFIED DRUG;

ADRENAL INSUFFICIENCY; ADULT; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CORTICOSTEROID RELEASE; ENZYME INHIBITION; FEMALE; GERMANY; HORMONE ACTION; HUMAN; KIDNEY; MALE; POTASSIUM URINE LEVEL; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROGESTERONE URINE LEVEL; SODIUM URINE LEVEL;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; 17-ALPHA-HYDROXYPROGESTERONE; ADRENAL CORTEX DISEASES; ADULT; ALDOSTERONE; ANDROSTENEDIONE; DESOXYCORTICOSTERONE; ENZYME INHIBITORS; FEMALE; FLUDROCORTISONE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; INFUSIONS, INTRAVENOUS; KIDNEY; MALE; MIDDLE AGED; MINERALOCORTICOIDS; POSTMENOPAUSE; POTASSIUM; PREDNISOLONE; PREDNISONE; PROGESTERONE; SODIUM; URODYNAMICS;

EID: 0041382364     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030092     Document Type: Article

References (30)

1. Rupprecht R, Reul JM, van Steensel B, Spengler D, Soder M, Berning B, Holsboer F, Damm K 1993 Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol 247:145-154
2. Myles K, Funder JW 1996 Progesterone binding to mineralocorticoid receptors: in vitro and in vivo studies. Am J Physiol 270:E601-E607
3. Quinkler M, Meyer B, Bumke-Vogt C, Grossmann C, Gruber U, Oelkers W, Diederich S, Bähr V 2002 Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor. Eur J Endocrinol 146:789-799
4. Dunn JF, Nisula BC, Rodbard D 1981 Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 53:58-68
5. 18 substituent. Endocrinology 136:5651-5658
6. Quinkler M, Johanssen S, Grossmann C, Bähr V, Müller M, Oelkers W, Diederich S 1999 Progesterone metabolism in the human kidney and inhibition of 11β-hydroxysteroid dehydrogenase type 2 by progesterone and its metabolites. J Clin Endocrinol Metab 84:4165-4171
7. Quinkler M, Johanssen S, Bumke-Vogt C, Oelkers W, Bähr V, Diederich S 2001 Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney. Mol Cell Endocrinol 171:21-24
8. Oelkers WK 1996 Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure. Steroids 61:166-171
9. Murakami T, Watanabe OE, Tanaka Y, Yamamoto M 2000 High blood pressure lowered by pregnancy. Lancet 356:1980
10. Allolio B, Oremus M, Reincke M, Schaeffer H-J, Winkelmann W, Heck G, Schulte HM 1995 High-dose progesterone infusion in healthy males: evidence against antiglucocorticoid activity of progesterone. Eur J Endocrinol 133:696-700
11. Bäckström T, Zetterlund B, Blom S, Romano M 1984 Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy. Acta Neurol Scand 69:240-248
12. Lee A, Ellis G 1991 Serum 17α-hydroxyprogesterone in infants and children as measured by a direct radioimmunoassay kit. Clin Biochem 24:505-511
13. Deinum J, Derkx FH, Schalekamp MA 1999 Improved immunoradiometric assay for plasma renin. Clin Chem 45:847-854
14. + absorption in epithelial cells from Xenopus kidney (A6). J Comp Physiol 171:377-386
15. Stockand JD 2002 New ideas about aldosterone signaling in epithelia. Am J Physiol 282:F559-F576
16. Laidlaw JC, Ruse JL, Gornall AG 1962 The influence of estrogen and progesterone on aldosterone excretion. J Clin Endocrinol Metab 22:161-171
17. Landau RL, Bergenstal DM, Lugibihl K, Kascht ME 1955 The metabolic effects of progesterone in man. J Clin Endocrinol Metab 15:1194-1215
18. Landau RL, Lugibihl K, Bergenstal DM, Dimick DF 1957 The metabolic effects of progesterone in man: dose response relationships. J Lab Clin Med 50:613-620
19. Landau RL, Lugibihl K 1958 Inhibition of the sodium-retaining influence of aldosterone by progesterone. J Clin Endocrinol Metab 18:1237-1245
20. Oparil S, Ehrlich EN, Lindheimer MD 1975 Effect of progesterone on renal sodium handling in man: relation to aldosterone excretion and plasma renin activity. Clin Sci Mol Med 49:139-147
21. Oelkers W, Schöneshöfer M, Blümel A 1974 Effects of progesterone and four synthetic progestagens on sodium balance and the renin-aldosterone system in man. J Clin Endocrinol Metab 39:882-890
22. Mujais SK, Nora NA, Chen Y 1993 Regulation of the renal Na:K pump: role of progesterone. J Am Soc Nephrol 3:1488-1495
23. Chapman AB, Zamudio S, Woodmansee W, Merouani A, Osorio F, Johnson A, Moore LG, Dahms T, Coffin C, Abraham WT, Schrier RW 1997 Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy. Am J Physiol 273:F777-F782
24. Miller WL 1988 Molecular biology of steroid hormone synthesis. Endocr Rev 9:295-318
25. Auchus RJ, Lee TC, Miller WL 1998 Cytochrome b5 augments the 17, 20-lyase activity of human P450c17 without direct electron transfer. J Biol Chem 273:3158-3165
26. Arlt W, Justl HG, Callies F, Reincke M, Hubler D, Oettel M, Ernst M, Schulte HM, Allolio B 1998 Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression. J Clin Endocrinol Metab 83:1928-1934
27. Winkel CA, Simpson ER, Milewich L, MacDonald PC 1980 Deoxycorticosterone biosynthesis in human kidney: potential for formation of a potent mineralocorticosteroid in its site of action. Proc Natl Acad Sci USA 77:7069-7073
28. Winkel CA, Casey ML, Simpson ER, MacDonald PC 1981 Deoxycorticosterone biosynthesis from progesterone in kidney tissue of the human fetus. J Clin Endocrinol Metab 53:10-15
29. McShane PM, Fencl MD 1983 Conversion of progesterone to corticosteroids by the midterm fetal adrenal and kidney. Steroids 42:299-310
30. Casey ML, MacDonald PC 1982 Formation of deoxycorticosterone from progesterone in extraadrenal tissues: demonstration of steroid 21-hydroxylase activity in human aorta. J Clin Endocrinol Metab 55:804-806