Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

Tetrahedron Letters

Volumn 51, Issue 41, 2010, Pages 5385-5387

  Stazi, Federica ^a   Cancogni, Damiano ^a   Turco, Lucilla ^a   Westerduin, Pieter ^a   Bacchi, Sergio ^a  

^a GSK   (Italy)

Author keywords

1,3 Cycloaddition; Aryl 1,2,3 triazoles; Flow chemistry; Organic azides

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ANILINE DERIVATIVE; AROMATIC AMINE; AZIDE;

ARTICLE; CONTINUOUS FLOW REACTOR; HIGH TEMPERATURE; SYNTHESIS;

EID: 79952137319     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.07.149     Document Type: Article

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27. Reactions were first tried on a batch mode to determine the residence time for the cyclization step. For all the compounds reported in Table 1 the formation of the azide was completed in 20 min. A prolonged reaction time (30 min) had no impact on the purity of the intermediate azide, at least by NMR.
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