A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

Tetrahedron Letters

Volumn 50, Issue 52, 2009, Pages 7263-7267

  Malet Sanz, Laia ^a   Madrzak, Julia ^a   Holvey, Rhian S ^a   Underwood, Toby ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Alkyl nitrites; Continuous flow; Diazo compounds; Flow chemistry; Iododeamination

Indexed keywords

AMINE; AROMATIC AMINE; IODINE DERIVATIVE;

AMINATION; ARTICLE; REACTOR; RELIABILITY; ROOM TEMPERATURE; SAFETY; SYNTHESIS;

EID: 70449134724     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.10.007     Document Type: Article

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44. 4, filtered and concentrated under reduced pressure to yield a solid. The solid was preloaded onto silica and purified by flash column chromatography with 40 g of silica and 0-10% of EtOAc in heptane. Fractions bearing the product were combined and evaporated to yield the corresponding iodide (see Table 1 for individual yields). Please see Supplementary data for the analytical data.
45. 3, 400 MHz): δ = 7.85 (d, 2H, 8.59 Hz), 7.37 (d, 2H, 8.59 Hz).
46. 3, 400 MHz): δ = 7.85 (d, 2H, 8.59 Hz), 7.37 (d, 2H, 8.59 Hz).