Partial role of nitric oxide in infarct size limiting effect of quercetin and rutin against ischemia-reperfusion injury in normal and diabetic rats

Indian Journal of Experimental Biology

Volumn 49, Issue 3, 2011, Pages 207-210

  Challa, Siva Reddy ^a   Akula, Annapurna ^a   Metla, Sushmitha ^a   Gopal, Pasumarthy N V ^b  

^a ANDHRA UNIVERSITY   (India)

^b HINDU COLLEGE OF PHARMACY   (India)

Author keywords

Cardioprotection; Infarct size; Nitric oxide; Quercetin; Reperfusion injury

Indexed keywords

CARDIOTONIC AGENT; ENZYME INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; QUERCETIN; RUTOSIDE;

ANIMAL; ARTICLE; DRUG ANTAGONISM; EXPERIMENTAL DIABETES MELLITUS; FEMALE; HEART INFARCTION; MALE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; CARDIOTONIC AGENTS; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; FEMALE; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; QUERCETIN; RATS; RATS, WISTAR; RUTIN;

RATTUS;

EID: 79952126460     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Hertog MG, Feskens EJ, Hollma PC, Katan, MB & Kromhout D, Dietary antioxidant flavonoids and risk of coronary heart disease: The zutphen elderly study, Lancet, 342 (1993) 1007.
2. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic SI, Pekkarinen M, Simic BS, Toshima H, Feskens EJM, Hollman PCH & Katan MB, Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study, Arch Intern Med, 155 (1995) 381.
3. Middleton E, Kandaswami C & Theoharides TC, The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer, Pharmacol Rev, 52(4) (2000) 673.
4. Annapurna A, Reddy CS, Akondi RB & Rao SRC, Cardio protective actions of two bioflavonoids,quercetin and rutinin experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats, J Pharmac Pharmacol,61(2009)1.
5. Benito S, Lopez D, Saiz MP, Buxaderas S, Sanchez J, Puig-Parellada P & Mitjavila MT, A flavonoidrich diet increase nitric oxide production in rat aorta, Br J Pharmacol, 135 (2002) 910.
6. Ajay M & Mustafa MR, Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta, J Cardiovas Pharmacol, 46 (2005) 36.
7. Maulik N, Engelman DT, Watanabe M, Engelman RM, Maulik G, Cordis GA & Das DK, Nitric oxide signaling in ischemic heart, Cardiovas Res, 30(4) (1995) 593.
8. Fishbein MC, Meerbaum S & Rit J, Early phase acute myocardial infarct size quantification. Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique, Am Heart J, 101(1981) 593.
9. Dhalla NS, Elmoselhi AB, Hata T & Makino N, Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res, 47 (2000) 446.
10. Ambrosio G & Tritto I, Reperfusion injury: Experimental evidence and clinical implications, Am Heart J, 138(1999) S69.
11. Stockklauser-Farber K, Ballhausen T, Laufer A & Rosen P. Influence of diabetes on cardiac nitric oxide synthase expression and activity. Biochim Biophys Acta, 1535 (2000)10.
12. Pou S, Pou WS, Bredt DS, Snyder SH & Rosen GM, Generation of superoxide by purified brain nitric oxide synthase, J Biol Chem, 267 (1992) 24173.
13. Hollman PCH, de Vries JHM, van Leeuwen SD, Mengelers MJB & Katan MB, Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers, Am J Clin Nutr, 62 (1996) 1276.
14. Okushio K, Matsumoto N, Kohri T, Suzuki M, Nanjo F & Hara Y, Absorption of tea catechins into rat portal vein, Boil Pharm Bull,19 (1996) 326.
15. Aldini G, Marina C, Angela P, Giuseppe R & Roberto MF, Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: New evidences for cardio-protection, Life Sciences, 73 (22) (2003) 2883.