Temporal acquisition of sequential mutations in the enhancer II and basal core promoter of HBV in individuals at high risk for hepatocellular carcinoma

Carcinogenesis

Volumn 32, Issue 1, 2011, Pages 63-68

  Bai, Xin ^a   Zhu, Yu ^a,b   Jin, Yan ^a   Guo, Xia ^a   Qian, Gengsun ^a   Chen, Taoyang ^c   Zhang, Jing ^d   Wang, Jinbing ^c   Groopman, John D ^e   Gu, Jianren ^a   Tu, Hong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY   (China)

^c QIDONG LIVER CANCER INSTITUTE   (China)

^d Shanghai Dahua Hospital   (China)

^e The Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER RISK; CHINA; CROSS-SECTIONAL STUDY; ENHANCER REGION; FEMALE; GENE SEQUENCE; GENETIC ASSOCIATION; HEPATITIS B; HEPATITIS B VIRUS; HIGH RISK PATIENT; HUMAN; LIVER CELL CARCINOMA; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; GENETICS; LIVER TUMOR; MIDDLE AGED; MUTATION; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; VIROLOGY; VIRUS GENE;

CARCINOMA, HEPATOCELLULAR; CROSS-SECTIONAL STUDIES; FEMALE; GENES, VIRAL; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MUTATION; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS;

EID: 79952115426     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq195     Document Type: Article

References (38)

1. Parkin,D.M. (2001) Global cancer statistics in the year 2000. Lancet Oncol., 2, 533-543.
2. Lin,C.L. et al. (2008) Hepatitis B viral factors and clinical outcomes of chronic hepatitis B. J. Biomed. Sci., 15, 137-145.
3. Kramvis,A. et al. (1999) The core promoter of hepatitis B virus. J. Viral Hepat., 6, 415-427.
4. Yuh,C.H. et al. (1990) The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its function. J. Virol., 64, 4281-4287.
5. Yuh,C.H. et al. (1993) Differentiated liver cell specificity of the second enhancer of hepatitis B virus. J. Virol., 67, 142-149.
6. Yuen,M.F. et al. (2004) Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study. Carcinogenesis, 25, 1593-1598.
7. Yuen,M.F. et al. (2008) Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels. Gut, 57, 98-102.
8. Baptista,M. et al. (1999) High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology, 29, 946-953.
9. Kao,J.H. et al. (2003) Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology, 124, 327-334.
10. Liu,C.J. et al. (2006) Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study. J. Infect. Dis., 194, 594-599.
11. Tanaka,Y. et al. (2006) Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma. J. Hepatol., 45, 646-653.
12. Yang,H.I. et al. (2008) Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J. Natl Cancer Inst., 100, 1134-1143.
13. Kuang,S.Y. et al. (2004) Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc. Natl Acad. Sci. USA, 101, 3575- 3580.
14. Chan,H.L. et al. (2004) Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut, 53, 1494- 1498.
15. Chun,Y.K. et al. (2000) No significant correlation exists between core promoter mutations, viral replication, and liver damage in chronic hepatitis B infection. Hepatology, 32, 1154-1162.
16. Chan,H.L. et al. (2000) Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong. Hepatology, 31, 763-768.
17. Guo,X. et al. (2008) Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China. J. Hepatol., 49, 718- 725.
18. Takahashi,K. et al. (1999) Clinical implications of mutations C-to-T1653 and T-to-C/A/G1753 of hepatitis B virus genotype C genome in chronic liver disease. Arch. Virol., 144, 1299-1308.
19. Liu,S. et al. (2009) Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. J. Natl Cancer Inst., 101, 1066-1082.
20. Pujol,F.H. et al. (2009)Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma. Cancer Lett., 286, 80-88.
21. Sumi,H. et al. (2003) Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. Hepatology, 37, 19-26.
22. Orito,E. et al. (2005) Differences of hepatocellular carcinoma patients with hepatitis B virus genotypes of Ba, Bj or C in Japan. Intervirology, 48, 239- 245.
23. Kao,J.H. et al. (2000) Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology, 118, 554- 559.
24. Yuen,M.F. et al. (2009) Hepatocellular carcinoma in the Asia pacific region. J. Gastroenterol. Hepatol., 24, 346-353.
25. Chen,J.G. et al. (2006) Trends in the incidence of cancer in Qidong, China, 1978-2002. Int. J. Cancer, 119, 1447-1454.
26. Ming,L. et al. (2002) Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology, 36, 1214- 1220.
27. Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association (2007) Guideline on prevention and treatment of chronic hepatitis B in China (2005). Chin. Med. J. (Engl.), 120, 2159-2173.
28. Ito,K. et al. (2006) T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection. Clin. Infect. Dis., 42, 1-7.
29. Kim,J.K. et al. (2009) Specific mutations in the enhancer II/core promoter/ precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma. J. Med. Virol., 81, 1002-1008.
30. Wang,Z. et al. (2007) Clinical and virological characteristics of hepatitis B virus subgenotypes Ba, C1, and C2 in China. J. Clin. Microbiol., 45, 1491- 1496.
31. Yuan,J. et al. (2007) Hepatitis B virus (HBV) genotypes/subgenotypes in China: mutations in core promoter and precore/core and their clinical implications. J. Clin. Virol., 39, 87-93.
32. Chen,C.H. et al. (2008) Combined mutations in pre-s/surface and core promoter/precore regions of hepatitis B virus increase the risk of hepatocellular carcinoma: a case-control study. J. Infect. Dis., 198, 1634-1642.
33. Buckwold,V.E. et al. (1996) Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J. Virol., 70, 5845-5851.
34. Moriyama,K. et al. (1996) Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigenseronegative persistent infections. Virology, 226, 269-280.
35. Jammeh,S. et al. (2008) Effect of basal core promoter and pre-core mutations on hepatitis B virus replication. J. Gen. Virol., 89, 901-909.
36. Parekh,S. et al. (2003) Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J. Virol., 77, 6601-6612.
37. Muroyama,R. et al. (2006) Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma. J. Hepatol., 45, 805-812.
38. Chou,Y.C. et al. (2008) Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma. Gut, 57, 91-97