The relationship between pregnancyassociated plasma protein-A (PAPP-A) and human intervertebral disc degeneration

Histology and Histopathology

Volumn 25, Issue 11, 2010, Pages 1431-1436

  Gruber, Helen E ^a   Buchanan, Laura ^a   Ingram, Jane A ^a   Zinchenko, Natalia ^a   James Norton, H ^b   Hanley Jr , Edward N ^a  

^a Department of Orthopaedic Surgery ^*  (United States)

^b CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Disc degeneration; Immunocytochemistry; PAPP A

Indexed keywords

PREGNANCY ASSOCIATED PLASMA PROTEIN A;

AGING; ARTICLE; BIOSYNTHESIS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY;

AGING; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MALE; MIDDLE AGED; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A;

EID: 79952110205     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Abe Y., Akeda K., An H.S., Aoki Y., Pichika R., Muehleman C., Kimura T. and Masuda K. (2007). Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine 32, 635-642.
2. Bayes-Genis A., Schwartz R.S., Lewis D.A., Overgaard M.T., Christiansen M., Oxvig C., Ashai K., Homes D.R. Jr and Conover C.A. (2001). Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty. Arterioscler. Thromb. Vasc. Biol. 21, 335-341.
3. Boldt H.B. and Conover C.A. (2007). Pregnancy-associated plasma protein -A (PAPP-A): A local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Hormone IGF Res. 17, 10-18.
4. Conover C.A., Chen B.-K. and Resch Z.T. (2004). Regulation of pregnancy-associated plasma protein-A expression in cultured human osteoblasts. Bone 34, 297-302.
5. Conover C.A., Bale L.K., Harrington S.C., Resch Z.T., Overgaard, M.T. and Oxvig C. (2006). Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol. Am. J. Physiol. Cell Physiol. 290, C183-C188.
6. Freemont A.J., Watkins A., LeMaitre C., Jeziorska M. and Hoyland J.A. (2002). Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J. Pathol. 196, 374-379.
7. Gruber H.E., Norton H.J. and Hanley E.N. Jr (2000). Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine 25, 2153-2157.
8. Gruber H.E., Hoelscher G., Ingram J., Bethea S. and Hanley E.N. Jr (2008a). IGF-1 rescues human intervertebral annulus cells from in vitro stress-induced premature senescence. Growth Factors 26, 220-225.
9. Gruber H.E., Hoelscher G.L., Ingram J.A. and Hanley E.N. (2008b). Immunolocalization and biochemical evidence of pregnancyassociated plasma protein-A (PAPP-A) in the intervertebral disc. Spine 33, E447-E454.
10. Gruber H.E., Hoelscher G.L., Deepe R. and Hanley E.N. Jr (2010). IL-1 and TNF-a stimulate pregnancy-associated plasma protein A production in human annulus cells in three-dimensional culture. Orthopaedic Research Society, 2010 abstracts.
11. Hoyland J.A., Le Maitre C. and Freemont A.J. (2008). Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology 47, 809-814.
12. Jia D. and Heersche J.N.M. (2007). Pregnancy-associated plasma protein-A proteolytic activity in rat vertebral cell cultures: Stimulation by dexamethasone - A potential mechanism for glucocorticoid regulation of osteoprogenitor proliferation and differentiation. J. Cell. Physiol. 204, 848-858.
13. Kumar A., Mohan S., Newton J., Rehage M., Tran K., Baylink D.J. and Qin X. (2005). Pregnancy-asssociated plasm protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism. J. Biol. Chem. 280, 37782-37789.
14. Lawrence J.B., Oxvig C., Overgaard M.T., Sottrup-Jensen L., Gleich G.J., Hayes L.G., Yates J.R. 3rd and Conover C.A. (1999). The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc. Natl. Acad. Sci. USA 96, 3149-3153.
15. LeMaitre C.L., Freemont A.J. and Hoyland J.A. (2005). The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res. Therapy 7, R732-R745.
16. Mazerbourg S., Overgaard M.T., Oxvig C., Christiansen M., Conover C.A., Laurendeau I., Vidaud M., Tosser-Klopp G., Zapf J. and Monget P. (2001). Pregnancy-associated plasma protein-A (PAPPA) in ovine, bovine, porcine, and equine ovarian follicles: Involvement in IGF binding protein-4 proteolytic degradation and mRNA expression during follicular development. Endocrinology 142, 5243-5253.
17. Okuda S., Myoui A., Ariga K., Nakase T., Yonenobu K. and Yoshikawa H. (2002). Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells. Spine 26, 2421-2426.
18. Ortiz C.O., Chen B.-K., Bale L.K., Overgaard M.T., Oxvig C. and Conover C.A. (2003). Transforming growth factor-' regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts. J. Bone Miner. Res. 18, 1066-1072.
19. Osada R., Ohshima H., Ishihara H., Yudoh K., Sakai K., Matsui H. and Tsuji H. (1996). Autocrine/paracrine mechanism of insulin-like growth factor- 1 secretion, and the effect of insulin-like growth factor- 1 on proteoglycan synthesis in bovine intervertebral discs. J. Orthop. Res. 14, 690-699.
20. Qin X., Wergedal J.E., Rehage M., Tran K., Newton J., Lam P., Baylink D.J. and Mohan S. (2006). Pregnancy-associated plasma protein-A increases osteoblast in vitro and bone formation in vivo. Endocrinology 147, 5653-5661.
21. Resch Z.T., Chen B.-K., Bale L.K., Oxvig C., Overgaard M.T. and Conover C.A. (2004). Pregnancy-associated plasma protein A gene expression as a target of inflammatory cytokines. Endocrinology 145, 1124-1129.
22. Seguin C.A., Pilliar R.M., Roughley P.J. and Kandel R.A. (2005). Tumor nectosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine 30, 1940-1948.
23. Sivanandam A.S., Mohan S., Kita H., Kapur S., Chen S.-T., Linkhart T.A., Bagi G., Baylink D.J. and Qin X. (2004). Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester. Biochem. J. 379, 57-64.
24. Tardig F., Reboul P., Pelletier J.P., Geng C. and Cloutier J.M.M.-P.J. (1996). Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins. Arthritis Rheum. 39, 968-978.
25. Thompson J.P., Pearce R.H., Schechter M.T., Adams M.E., Tsang I.K.Y. and Bishop P.B. (1990). Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 15, 411-415.
26. Walsh A.J.L., Bradford D.S. and Lotz J.C. (2004). In vivo growth factor treatment of degenerated intervertebral discs. Spine 29, 156-163.
27. Weiler C., Nerlich A.G., Bachmeier B.E. and Boos N. (2005). Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: A study in surgical specimen and autopsy controls. Spine 30, 44-53.