Activity of the julocrotine, a glutarimide alkaloid from Croton pullei var. glabrior, on Leishmania (L.) amazonensis

Parasitology Research

Volumn 107, Issue 5, 2010, Pages 1075-1081

  Guimarães, Leda R C ^a   Rodrigues, Ana Paula D ^a   Marinho, Patrícia S B ^a   Muller, Adolfo H ^a   Guilhon, Giselle M S ^a   Santos, Lourivaldo S ^a   Do Nascimento, José Luiz M ^a   Silva, Edilene O ^a  

^a FEDERAL UNIVERSITY OF PARÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; ANTIPROTOZOAL AGENT; JULOCROTINE; PIPERIDONE DERIVATIVE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ANIMAL; ARTICLE; CELL ORGANELLE; CHEMISTRY; COLORIMETRY; CROTON; DOSE RESPONSE; DRUG EFFECT; IC 50; ISOLATION AND PURIFICATION; LEISHMANIA; MACROPHAGE; METABOLISM; METHODOLOGY; MICROBIAL VIABILITY; MOUSE; PARASITOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ALKALOIDS; ANIMALS; ANTIPROTOZOAL AGENTS; COLORIMETRY; CROTON; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; LEISHMANIA; MACROPHAGES; MICE; MICROBIAL VIABILITY; MICROSCOPY, ELECTRON, TRANSMISSION; ORGANELLES; PARASITOLOGY; PIPERIDONES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 79952108335     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-010-1973-0     Document Type: Article

References (23)

1. Ashutosh SS, Goyal N (2007) Molecular mechanisms of antimony resistance in Leishmania. J Med Microbiol 56(PT 2):143-153
2. Barbosa PS, Abreu AS, Batista EF, Guilhon GMSP, Muller AH, Arruda MSP, Santos LS, Arruda AC, Secco RS (2007) Glutarimide alkaloids and terpenoids from Croton pullei var. glabrior Lanj. Biochem Syst Ecol 35:887-890 (Pubitemid 350018979)
3. Block S, Gerkens P, Peulen O, Jolois O, Mingeot-Leclercq MP, De Pauw-Gillet MC, Quetin-Leclercq J (2005) Induction of apoptosis in human promyelocytic leukemia cells by a natural trachylobane diterpene. Anticancer Res 25:363-368 (Pubitemid 40470131)
4. Brenzan MA, Nakamura CV, Filho BPD, Ueda-Nakamura T, Young MC, Cortez DAG (2007) Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis . Parasitol Res 101:715-722 (Pubitemid 47103125)
5. Chen M, Christensen SB, Blom J, Lemmich E, Nadelmann L, Fich K, Theander TG, Kharazam A (1993) Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrob Agents Chemother 37:2550-2556 (Pubitemid 23357845)
6. Croft SL, Coombs GH (2003) Leishmaniasis - current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol 19:502-508 (Pubitemid 37329659)
7. Croft SL, Sundar S, Fairlamb AH (2006) Drug resistance in leishmaniasis. Clin Microbiol Rev 19:111-126 (Pubitemid 43157649)
8. Delorenzi JC, Attias M, Gattass CR, Andrade M, Rezende C, Pinto AC, Henriques A, Bou-Habib D, Saraiva EM (2001) Antileish-manial activity of an indole alkaloid from Peshiera australis. Antimicrob Agents Chemother 45:1349-1354 (Pubitemid 32374101)
9. González P, Marín C, Rodríguez-González I, Hitos AB, Rosales MJ, Reina M, Díaz JG, González-Coloma A, Sánchez-Moreno M (2005) In vitro activity of C20-diterpeneoid alkaloid derivatives in promastigotes and intracellular amastigotes of Leishmania infantum. Intern J Antimicr Agents 25:136-141
10. Lainson R, Shaw JJ (2005) Leishmaniasis in the New Word. In: Collier L, Balows A, Sussman M (eds) Topley & Wilson's Microbiology and Microbial Infections, vol 5, Parasitology, 10th edn. Arnold, London, pp 313-349
11. Mishra BB, Kale RR, Singh RK, Tiwari VK (2009) Alkaloids: future prospective to combat leishmaniasis. Fitoterapia 80:81-90
12. Morales A, Pérez P, Mendoza R, Compagnone R, Suarez AI, Arvelo F, Ramírez JL, Galindo-Castro I (2005) Cytotoxic and proapoptotic activity of ent-16beta-17alpha- dihydroxykaurane on human mammary carcinoma cell line MCF-7. Cancer Lett 218:109-116 (Pubitemid 40082707)
13. Moreira RYO, Brasil DSB, Alves CN, Guilhon GMSP, Santos LS, Arruda MSP, Müller AH, Barbosa PS, Abreu AS, Silva EO, Rumjanek VM, Souza J Jr, da Silva ABF, Santos RHA (2008) Crystal structure and theoretical calculations of Julocrotine, a natural product with antileishmanial activity. Int J Quant Chem 108:513-520 (Pubitemid 350254211)
14. Paris C, Loiseau PM, Bories C, Bréard J (2004) Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob Agents Chemother 48:852-859 (Pubitemid 38280335)
15. Rodrigues JCF, Attias M, Rodriguez C, Urbina JA, de Souza W (2002) Ultrastructural and biochemical alterations induced by 22, 26-Azasterol, a delta 24(25)-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis. Antimicrob Agents Chemother 46:487-499 (Pubitemid 34087200)
16. Rodrigues JCF, Concepcion JL, Rodrigues C, Caldera A, Urbina JA, de Souza W (2008) In vitro activities of ER-119884 and E570, two potent squalene synthase inhibitors, against Leishmania amazonensis : antiproliferative, biochemical, and ultrastructural effects. Antimicrob Agents Chemother 52:4098-4114
17. Rosa MS, Mendonça-Filho RR, Bizzo HR, Rodrigues IA, Soares RM, Souto-Padrón T, Alviano CS, Lopes AH (2003) Antileishmanial activity of a linalol-rich essential oil from Croton cajucara. Antimicrob Agents Chemother 47:1895-1901 (Pubitemid 36637811)
18. Singh S, Sivakumar R (2004) Challenges and new discoveries in the treatment of leishmaniasis. J Infect Chemother 10:307-315 (Pubitemid 40142819)
19. Suárez AI, Blanco Z, Compagnone RS, Salazar-Bookaman MM, Zapata V, Alvarado C (2006) Anti-inflammatory activity of Croton cuneatus aqueous extract. J Ethnopharmacol 105:99-101
20. Tiuman TS, Ueda-Nakamura T, Cortez DAG, Dias Filho BP, Morgado-Díaz JA, de Souza W, Nakamura CV (2005) Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium. Antimicrob Agents Chemother 49:176-182 (Pubitemid 40065790)
21. Torres-Santos EC, Moreira DL, Kaplan MAC, Meirelles MN, Rossi- Bergmann B (1999) Selective effect of 2′, 6′-dihdroxy-4′-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis . Antimicrob Agents Chemother 43:1234-1241 (Pubitemid 29214753)
22. Vannier-Santos MA, Urbina JA, Martiny A, Neves A, de Souza W (1995) Alterations induced by the antifungal compounds ketoconazole and terbinafine in Leishmania. J Eukaryot Microbiol 42:337-346
23. World Health Organization (2009) Leishmaniasis: the global trend. http://www.who. int/neglected-diseases/integrated-media-leishmaniasis/en/index. html. Accessed 17 May 2009