Metabolism of zearalenone in the course of beer fermentation

Toxins

Volumn 3, Issue 2, 2011, Pages 134-141

  Mizutani, Kohei ^a   Nagatomi, Yasushi ^a   Mochizuki, Naoki ^a  

^a ASAHI BREWERIES LTD   (Japan)

Author keywords

Beer; Fermentation; Liquid chromatography tandem mass spectrometry (LC MS MS); Metabolite; Zearalenone

Indexed keywords

ALPHA ZEARALENOL; ALPHA ZERALANOL; BETA ZEARALENOL; BETA ZEARALENONE; BETA ZERALANOL; UNCLASSIFIED DRUG; ZEARALENONE; ZERANOL;

ANALYTIC METHOD; ARTICLE; BEER; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ESTROGEN ACTIVITY; FERMENTATION TECHNIQUE; LIQUID CHROMATOGRAPHY; MALT; METABOLITE; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; TOXIN ANALYSIS; TOXIN STRUCTURE; VALIDATION PROCESS;

BEER; ESTROGENS, NON-STEROIDAL; FERMENTATION; FOOD CONTAMINATION; SACCHAROMYCES; ZEARALENONE;

FUSARIUM;

EID: 79952092617     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins3020134     Document Type: Article

References (16)

1. Betina, V. Mycotoxins Chemical, Biological and Environmental Aspects; Betina, V., Ed.; Elsevier: Amsterdam, The Netherlands, 1989; Volume 9.
2. Hagler, W.M.; Mirocha, C.J. Biosynthesis of [14C] Zearalenone from [1-14C]Acetate by Fusarium reseum 'Gibbosum'. Appl. Environ. Microbiol. 1980, 39, 668-670.
3. Mirocha, C.J.; Schauerhamer, B.; Christensen, C.M.; Niku-Paavola, M.L. Nummi, M. Incidence of Zearalenol (Fusarium Mycotoxin) in Animal Feed. Appl. Environ. Microbiol. 1979, 38, 749-750.
4. Okoye, Z.S. Stability of zearalenone in naturally contaminated corn during Nigerian traditional brewing. Food Addit. Contam. 1987, 4, 57-59.
5. Scott, P.M. Mycotoxins transmitted into beer from contaminated grains during brewing. J. Assoc. Off. Anal. Chem. Int. 1996, 79, 875-882.
6. Shim, W.B.; Kim, J.C.; Seo, J.A.; Lee, Y.W. Natural occurrence of trichothecenes and zearalenone in Korean and imported beers. Food Addit. Contam. 1997, 14, 1-5.
7. Erasmuson, A.F.; Scahill, B.G.; West, D.M. Natural zeranol (α-zearalanol) in the urine of pasture-fed animals. J. Agric. Food Chem. 1994, 42, 2721-2725.
8. Jodlbauer, J.; Zöllner, P.; Lindner, W. Determination of zeranol, taleranol, zearalenone, α- and β-zearalenol in urine and tissue by high-performance liquid chromatography-tandem mass spectrometry. Chromatographia 2000, 51, 681-687.
9. World Health Organization. Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins; WHO Press: Geneva, Switzerland, 1993; pp. 523-524.
10. Shier, W.T.; Shier, A.C.; Xie, W.; Mirocha, C.J. Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins. Toxicon 2001, 39, 1435-1438.
11. Scott, P.M.; Kanhere, S.R.; Daley, E.F.; Farber, J.M. Fermentation of wort containing deoxynivalenol and zearalenone. Mycotoxin Res. 1992, 8, 58-66.
12. Zöllner, P.; Jodlbauer, J.; Lindner, W. Determination of zearalenone in grains by high-performance liquid chromatography-tandem mass spectrometry after solid-phase extraction with RP-18 columns or immunoaffinity columns. J. Chromatogr. A 1999, 858, 167-174.
13. Zöllner, P.; Berner, D.; Jodlbauer, J.; Lindner, W. Determination of zearalenone and its metabolites α- and β-zearalenol in beer samples by high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2000, 738, 233-241.
14. Rosenberg, E.; Krska, R.; Wissiack, R.; Kmetov, V.; Josephs, R.; Razzazi, E.; Grasserbauer, M. High-performance liquid chromatography-atmospheric-pressure chemical ionization mass spectrometry as a new tool for the determination of the mycotoxin zearalenone in food and feed. J. Chromatogr. A 1998, 819, 277-288.
15. Mochizuki, N.; Sugai, T.; Ohta, H. Biochemical reduction of 3-oxoalkanoic esters by a bottom-fermentation yeast, Saccharomyces cerevisiae IFO 0565. Biosci. Biotech. Biochem. 1994, 58, 1666-1670.
16. Fitzpatrick, D.W.; Picken, C.A.; Murphy, L.C.; Buhr, M.M. Measurement of the relative binding affinity of zearalenone, α-zearalenol and β-zearalenol for uterine and oviduct estrogen receptors in swine, rats and chickens: An indicator for estrogenic potencies. Comp. Biochem. Physiol. 1989, 94C, 691-694.