Colon targeted oral delivery of Ornidazole using combination of pH and time dependent drug delivery system

International Journal of Pharmaceutical Research

Volumn 2, Issue 1, 2010, Pages 28-35

  Patel, J M ^a   Brahmbhatt, M R ^a   Patel, V B ^a   Muley, S V ^b   Yeole, P G ^b  

^a K J College of Pharmacy   (India)

^b INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Colon targeted drug delivery system; Eudragit; Ornidazole; pH dependent; pH independent

Indexed keywords

EUDRAGIT; ORNIDAZOLE;

ARTICLE; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG FORMULATION; DRUG SOLUBILITY; DRUG TARGETING; FACTORIAL DESIGN; PH MEASUREMENT; PREDICTIVE VALUE; PROCESS OPTIMIZATION; RESPONSE VARIABLE; TABLET FORMULATION; TIMED DRUG RELEASE;

EID: 79952079992     PISSN: None     EISSN: 09752366     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. st ed. New Delhi: CBS Publishers and Distributors; 2001.
2. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J. Pharm. Sci. 2003; 6(1): 33-66.
3. Gupta VK, Beckert TE, Price JC. A novel pHand time-based multi-unit potential colonic drug delivery system II optimization of multiple response variable. Int. J. Pharm. 2001; 213: 83-91.
4. ® S100 combinations. J. Control. Release. 1999; 58: 215-222.
5. Akhgari A, Sadeghi F, Garekani HA. Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int. J. Pharm. 2006; 320(1-2): 137-142.
6. Meiling Q, Wang P, Wu D., A Novel pH-and Time-Dependent System for Colonic Drug Delivery. Drug Dev. Ind. Pharm. 2003; 29: 661-667.
7. Bott C, Rudolp, MW, Schneider AR, Schirrmacher S, Skalsky B, Petereit HU, Langguth P, Dressman JB, Stein J. In vivo evaluation of a novel pH- and time-based multiunit colonic drug delivery system. Aliment Pharmaco. Therapeutics. 2004; 20(3): 347-353.
8. Cheng G, An F, Zou MJ, Sun J, Hao XH, He YX. Time- and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid. World J. Gastroenterology. 2004; 10(12): 1769-1774.
9. thed. Washington: American Pharmaceutical Association; 2003.
10. Singh P, Mittal R, Sharma GC, Singh S. Profiles of Drug Substances, Excipients, and Related Methodology. Vol.30. New Delhi: A Division of Reed Elsevier India Private Limited; 2006.
11. th ed. New Delhi: Jaypee Brothers; 2003.
12. Krishnaiah YS, Muzib YI, Rao GS, Bhaskar P, Satyanarayana V. Studies on the development of colon targeted oral drug delivery systems for ornidazole in the treatment of amoebiasis. Drug Deliv. 2003; 10 (2): 111-117.
13. nd ed. U.S.A: Marcel Dekker Inc; 2002.