Nuclear localization of E-cadherin but not beta-catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stroma

Histopathology

Volumn 58, Issue 3, 2011, Pages 423-432

  Ohishi, Yoshihiro ^a,b   Oda, Yoshinao ^a   Kurihara, Shuichi ^a   Kaku, Tsunehisa ^c   Kobayashi, Hiroaki ^d   Wake, Norio ^d   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY BEPPU HOSPITAL   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Beta catenin; E cadherin; Granulosa cell tumour; Normal ovary; Nuclear localization

Indexed keywords

BETA CATENIN; UVOMORULIN;

ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; FEMALE; GRANULOSA CELL; GRANULOSA CELL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NUCLEAR LOCALIZATION SIGNAL; OVARY FOLLICLE; OVARY FOLLICLE DEVELOPMENT; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STROMA CELL;

BETA CATENIN; CADHERINS; CELL NUCLEUS; FEMALE; GRANULOSA CELL TUMOR; GRANULOSA CELLS; HUMANS; OVARIAN FOLLICLE; OVARIAN NEOPLASMS; OVARY; SIGNAL TRANSDUCTION;

EID: 79952075269     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.03761.x     Document Type: Article

References (44)

1. Bjorkholm E. Granulosa cell tumors: a comparison of survival in patients and matched controls. Am. J. Obstet. Gynecol. 1980; 138; 329-331.
2. Bjorkholm E, Silfversward C. Prognostic factors in granulosa cell tumors. Gynecol. Oncol. 1981; 11; 261.
3. Ohishi Y, Kaku T, Oya M et al. CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls. Gynecol. Oncol. 2007; 107; 30-38.
4. Stenwig JT, Hazekamp JT, Beecham JB. Granulosa cell tumors of ovary. A clinicopathological study of 118 cases with long-term follow-up. Gynecol. Oncol. 1979; 7; 136-152.
5. Prat J. Sex cord-stromal tumors. In Prat J ed. Pathology of the ovary. Philadelphia: Elsevier, 2004; 197-229.
6. Fuller PJ, Verity K, Shen Y et al. No evidence of a role for mutations or polymorphisms of the follicle-stimulating hormone receptor in ovarian granulosa cell tumors. J. Clin. Endocrinol. Metab. 1998; 83; 274-279.
7. Giacaglia LR, Kohec MB da F, Carvalho FM et al. No evidence of somatic activating mutations on gonadotropin receptor genes in sex cord stromal tumors. Fertil. Steril. 2000; 74; 922-925.
8. Kotler T, Young RH, Albanese C et al. Absence of mutations in the FSH receptor in ovarian granulosa cell tumors. J. Clin. Endocrinol. Metab. 1998; 83; 3001.
9. Shen Y, Mamers P, Jobling T et al. Absence of the previously reported Gprotein oncogene (gip2) in ovarian granulosa cell tumors. J. Clin. Endocrinol. Metab. 1996; 81; 4159-4161.
10. Jamieson S, Alexiadis M, Fuller PJ. Expression status and mutational analysis of the ras and B-raf genes in ovarian granulosa cell and epithelial tumors. Gynecol. Oncol. 2004; 95; 603-609.
11. Sieben NL, Macropoulos P, Roemen GM et al. In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J. Pathol. 2004; 202; 336-340.
12. Coppes MJ, Ye Y, Rackley R et al. Analysis of WT1 in granulosa cell and other sex cord-stromal tumors. Cancer Res. 1993; 53; 271-274.
13. Kappes S, Milde-Langosch K, Kressin P et al. p53 mutations in ovarian tumors, detected by temperature-gradient gel electrophoresis, direct sequencing and immunohistochemistry. Int. J. Cancer 1995; 64; 52-59.
14. Liu FS, Ho ES, Lai CR et al. Overexpression of p53 is not a feature of ovarian granulosa cell tumors. Gynecol. Oncol. 1996; 61; 50-53.
15. Nelson WJ, Nusse R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 2004; 303; 1483-1487.
16. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 2003; 1653; 1-24.
17. Lustig B, Behrens J. The Wnt signaling pathway and its role in tumor development. J. Clin. Endocrinol. Metab. 2003; 129; 199-221.
18. Boerboom D, Paquet M, Hsieh M et al. Misregulated Wnt/β-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res. 2005; 65; 9206-9215.
19. Chetty R, Serra S. Nuclear E-cadherin immunoexpression: from biology to potential application in diagnostic pathology. Adv. Anat. Pathol. 2008; 15; 234-240.
20. Allred DC, Harvey JM, Berardo M et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod. Pathol. 1998; 11; 155-168.
21. Hsieh M, Johnson MA, Greenberg NM et al. Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary. Endocrinology 2002; 143; 898-908.
22. Hsieh M, Mulders SM, Friis RR et al. Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells. Endocrinology 2003; 144; 4597-4606.
23. Richards JS, Russell DL, Ochsner S et al. Novel signaling pathway that controls ovarian follicular development, ovulation, and luteinization. Recent Prog. Horm. Res. 2002; 57; 195-220.
24. Ricken A, Lochhead P, Kontogiannea M et al. Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. Endocrinology 2002; 143; 2741-2749.
25. Ferber EC, Kajita M, Wadlow A et al. A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. J. Biol. Chem. 2008; 283; 12691-12700.
26. Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signaling. Nat. Rev. Mol. Cell Biol. 2002; 3; 673-684.
27. Gao Y, Pimplikar SW. The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to nucleus. Proc. Natl Acad. Sci. USA 2001; 98; 14979-14984.
28. Haas IG, Frank M, Veron N et al. Presinilin-dependent processing and nuclear function of γ-protocadherins. J. Biol. Chem. 2005; 280; 9313-9319.
29. Hambsh B, Grinevich V, Seeburg PH et al. γ-Protocadherins, presinilin-mediated release of C-terminal fragment promotes locus expression. J. Biol. Chem. 2005; 280; 15888-15897.
30. Marambaud P, Wen PH, Dutt A et al. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 2003; 114; 635-645.
31. Maretzky T, Reiss K, Ludwig A et al. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc. Natl Acad. Sci. USA 2005; 102; 9182-9187.
32. Ni CY, Murphy MP, Golde TE et al. γ-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 2001; 294; 2179-2181.
33. Okamoto I, Kawano Y, Murakami D et al. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J. Cell Biol. 2001; 155; 755-762.
34. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signaling requires ligand-induced proteolytic release of intracellular domain. Nature 1998; 393; 382-386.
35. Shoval I, Ludwig A, Kalcheim C. Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination. Development 2007; 134; 491-501.
36. Struhl G, Adachi A. Nuclear access and action of notch in vivo. Cell 1998; 93; 649-660.
37. Uemura K, Kihara T, Kuzuya A et al. Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. Biochem. Biophys. Res. Commun. 2006; 345; 951-958.
38. ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol. Cell. Biol. 1999; 19; 3614-3623.
39. Hosking CR, Ulloa F, Hogan C et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol. Cell. Biol. 2007; 18; 1918-1927.
40. ctn is necessary to relieve Kaiso-mediated transcriptional repression. J. Cell Sci. 2004; 117; 2675-2686.
41. ctn-binding partner Kaiso is a bimodal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res. 2002; 30; 2911-2919.
42. Liu H, Komiya S, Shimizu M et al. Involvement of p120 carboxy-terminal domain in cadherin trafficking. Cell Struct Funct. 2007; 32; 127-137.
43. Miyashita Y, Ozawa M. Increased internalization of p120-uncoupled E-cadherin and a requirement for a dileucin motif in the cytoplasmic domain for endocytosis of protein. J. Biol. Chem. 2007; 282; 11540-11548.
44. Peifer M, Yap AS. Traffic control: p120-catenin acts as a gatekeeper to control the fate of classic cadherin in mammalian cells. J. Cell Biol. 2003; 163; 437-440.