Upregulation of TLR2 and TLR4 in the human adrenocortical cells differentially modulates adrenal steroidogenesis

Molecular and Cellular Endocrinology

Volumn 336, Issue 1-2, 2011, Pages 41-46

  Kanczkowski, Waldemar ^a   Tymoszuk, Piotr ^a   Chavakis, Triantafyllos ^a   Janitzky, Volker ^b   Weirich, Torsten ^b   Zacharowski, Kai ^c   Ehrhart Bornstein, Monika ^a   Bornstein, Stefan R ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b Department of Urology   (Germany)

^c Clinic of Anaesthesiology   (Germany)

Author keywords

Adrenal dysfunction; Adrenal insufficiency; Immune adrenal crosstalk; Pattern recognition receptors; Steroidogenesis

Indexed keywords

ALDOSTERONE; CD14 ANTIGEN; COMPLEMENTARY DNA; HYDROCORTISONE; MESSENGER RNA; STEROID HORMONE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ADRENAL CORTEX CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DNA SYNTHESIS; GENETIC TRANSFECTION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ISOLATION; STEROIDOGENESIS; UPREGULATION;

ADRENAL CORTEX; ANTIGENS, CD14; CELL LINE; CHOLESTEROL; CLONE CELLS; HUMANS; STEROIDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 79952073915     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.12.013     Document Type: Article

References (26)

1. Angus D.C., Wax R.S. Epidemiology of sepsis: an update. Crit. Care Med. 2001, 29:S109-S116.
2. Beishuizen A., Thijs L.G. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J. Endotoxin. Res. 2003, 9:3-24.
3. Bornstein S.R. Predisposing factors for adrenal insufficiency. N. Engl. J. Med. 2009, 360:2328-2339.
4. Bornstein S.R., Schumann R.R., Rettori V., McCann S.M., Zacharowski K. Toll-like receptor 2 and Toll-like receptor 4 expression in human adrenals. Horm. Metab. Res. 2004, 36:470-473.
5. Bornstein S.R., Zacharowski P., Schumann R.R., Barthel A., Tran N., Papewalis C., et al. Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:16695-16700.
6. Brandl K., Gluck T., Huber C., Salzberger B., Falk W., Hartmann P. TLR4 surface display on human monocytes is increased in septic patients. Eur. J. Med. Res. 2005, 10:319-324.
7. Chai W., Hofland J., Jansen P.M., Garrelds I.M., de V.R., van den Bogaerdt A.J., et al. Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors?. J. Hypertens. 2010, 28:1044-1053.
8. El-Achkar T.M., Huang X., Plotkin Z., Sandoval R.M., Rhodes G.J., Dagher P.C. Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney. Am. J. Physiol. Renal. Physiol. 2006, 290:F1034-F1043.
9. Gallo-Payet N., Roussy J.F., Chagnon F., Roberge C., Lesur O. Hypothalamic-pituitary-adrenal axis and multiple organ dysfunction syndrome in critical illness: A special focus on arginine-vasopresine and apelin. J. Organ Dysfunct. 2008, 4:216-229.
10. Garcia R., Enriquez de S.A., Portoles M.T. Calcium and reactive oxygen species as messengers in endotoxin action on adrenocortical cells. Biochim. Biophys. Acta 1999, 1454:1-10.
11. Hennessy E.J., Parker A.E., O'Neill L.A. Targeting Toll-like receptors: emerging therapeutics?. Nat. Rev. Drug Discov. 2010, 9:293-307.
12. Kanczkowski W., Zacharowski K., Wirth M.P., Ehrhart-Bornstein M., Bornstein S.R. Differential expression and action of Toll-like receptors in human adrenocortical cells. Mol. Cell. Endocrinol. 2009, 300:57-65.
13. Kanczkowski, Tymoszuk P., Ehrhart-Bornstein W., Wirth M., Zacharowski M.P., Bornstein K. S.R. Abrogation of TLR4 and CD14 expression and signaling in human adrenocortical tumors. J. Clin. Endocrinol. Metab. 2010, 95:E421-E429.
14. Koo D.J., Jackman D., Chaudry I.H., Wang P. Adrenal insufficiency during the late stage of polymicrobial sepsis. Crit. Care Med. 2001, 29:618-622.
15. Leulier F., Lemaitre B. Toll-like receptors - taking an evolutionary approach. Nat. Rev. Genet. 2008, 9:165-178.
16. Marx C., Petros S., Bornstein S.R., Weise M., Wendt M., Menschikowski M., et al. Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol. Crit. Care Med. 2003, 31:1382-1388.
17. McCallum R.E., Stith R.D. Endotoxin-induced inhibition of steroid binding by mouse liver cytosol. Circ. Shock 1982, 9:357-367.
18. Prigent H., Maxime V., Annane D. Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Crit. Care 2004, 8:243-252.
19. Rainey W.E., Saner K., Schimmer B.P. Adrenocortical cell lines. Mol. Cell. Endocrinol. 2004, 228:23-38.
20. Russell J.A. Management of sepsis. N. Engl. J. Med. 2006, 355:1699-1713.
21. Salomao R., Brunialti M.K., Gomes N.E., Mendes M.E., Diaz R.S., Komninakis S., et al. Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock. Crit. Care Med. 2009, 37:132-139.
22. Sprung C.L., Annane D., Keh D., Moreno R., Singer M., Freivogel K., et al. Hydrocortisone therapy for patients with septic shock. N. Engl. J. Med. 2008, 358:111-124.
23. Tsujimoto H., Ono S., Majima T., Kawarabayashi N., Takayama E., Kinoshita M., et al. Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock 2005, 23:39-44.
24. van der Poll T. Immunotherapy of sepsis. Lancet Infect. Dis. 2001, 1:165-174.
25. Williams D.L., Ha T., Li C., Kalbfleisch J.H., Schweitzer J., Vogt W., et al. Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit. Care Med. 2003, 31:1808-1818.
26. Zacharowski K., Zacharowski P.A., Koch A., Baban A., Tran N., Berkels R., et al. Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:6392-6397.