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Volumn 44, Issue 2, 2011, Pages 140-145

PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation

Author keywords

Akt; Epinephrine; G 6983; Platelet aggregation; RO 31 8220

Indexed keywords


EID: 79952057097     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.2.140     Document Type: Article
Times cited : (29)

References (29)
  • 1
    • 0024532116 scopus 로고
    • Molecular mechanisms of platelet activation
    • Siess, W. (1989) Molecular mechanisms of platelet activation. Physiol. Rev. 69, 58-178.
    • (1989) Physiol. Rev. , vol.69 , pp. 58-178
    • Siess, W.1
  • 2
    • 0028302211 scopus 로고
    • Role of platelets in thrombosis and hemostasis
    • Packham, M. A. (1994) Role of platelets in thrombosis and hemostasis. Can. J. Physiol. Pharmacol. 72, 278-284.
    • (1994) Can. J. Physiol. Pharmacol. , vol.72 , pp. 278-284
    • Packham, M.A.1
  • 3
    • 0020576560 scopus 로고
    • Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization
    • Assoian, R. K., Komoriya, A., Meyers, C. A., Miller, D. M. and Sporn, M. B. (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J. Biol. Chem. 258, 7155-7160.
    • (1983) J. Biol. Chem. , vol.258 , pp. 7155-7160
    • Assoian, R.K.1    Komoriya, A.2    Meyers, C.A.3    Miller, D.M.4    Sporn, M.B.5
  • 5
    • 4444269330 scopus 로고    scopus 로고
    • Imparied platelet responses to thrombin and collagen in AKT-1-deficient mice
    • Chen, J., De, S., Damron, D. S., Chen, W. S., Hay, N. and Byzova, T. (2004) Imparied platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood 104, 1703-1710.
    • (2004) Blood , vol.104 , pp. 1703-1710
    • Chen, J.1    De, S.2    Damron, D.S.3    Chen, W.S.4    Hay, N.5    Byzova, T.6
  • 7
    • 0038627709 scopus 로고    scopus 로고
    • Apparent heterogeneous responsiveness of human platelet rich plasma to catecholamines
    • Pyo, M. K., Yun-Choi, H. S. and Hong, Y. J. (2003) Apparent heterogeneous responsiveness of human platelet rich plasma to catecholamines. Platelets. 14, 171-178.
    • (2003) Platelets , vol.14 , pp. 171-178
    • Pyo, M.K.1    Yun-Choi, H.S.2    Hong, Y.J.3
  • 8
    • 64649094772 scopus 로고    scopus 로고
    • Reduced GPIIb/IIIa expression in platelets hyposensitive to catecholamines when activated with TRAP
    • Kim, J. M., Koo, Y. K., Heo, J. E., Park, S. and Yun-Choi, H. S. (2009) Reduced GPIIb/IIIa expression in platelets hyposensitive to catecholamines when activated with TRAP. Throm. Res. 124, 90-95.
    • (2009) Throm. Res. , vol.124 , pp. 90-95
    • Kim, J.M.1    Koo, Y.K.2    Heo, J.E.3    Park, S.4    Yun-Choi, H.S.5
  • 10
    • 73649117108 scopus 로고    scopus 로고
    • Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines
    • Koo, Y. K., Kim, J. M., Kim, S. Y., Koo, J. Y., Oh, D., Park, S. and Yun-choi, H. S. (2009) Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines. Platelets. 20, 555-565.
    • (2009) Platelets , vol.20 , pp. 555-565
    • Koo, Y.K.1    Kim, J.M.2    Kim, S.Y.3    Koo, J.Y.4    Oh, D.5    Park, S.6    Yun-choi, H.S.7
  • 13
    • 0029945067 scopus 로고    scopus 로고
    • Role of catecholamines in platelet function: Pathophysiological and clinical significance
    • Anfossi, G. and Trovati, M. (1996) Role of catecholamines in platelet function: pathophysiological and clinical significance. Eur. J. Clin. Invest. 26, 353-370.
    • (1996) Eur. J. Clin. Invest. , vol.26 , pp. 353-370
    • Anfossi, G.1    Trovati, M.2
  • 15
    • 0028982032 scopus 로고
    • Phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits 5-hydroxytrypt-amine-mediated potentiation of platelet aggregation induced by epinephrine
    • Shah, B. H. and Saeed, S. A. (1995) Phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits 5-hydroxytrypt-amine-mediated potentiation of platelet aggregation induced by epinephrine. Res. Commun. Mol. Pathol. Pharmacol. 89, 157-164.
    • (1995) Res. Commun. Mol. Pathol. Pharmacol. , vol.89 , pp. 157-164
    • Shah, B.H.1    Saeed, S.A.2
  • 18
    • 0029830026 scopus 로고    scopus 로고
    • Protein kinase C inhibitor, chelerythrine, potentiates the adrenaline-mediated aggregation of human platelets through calcium influx
    • Shah, B. H., Shamim, G., Khan, S. and Saeed, S. A. (1996) Protein kinase C inhibitor, chelerythrine, potentiates the adrenaline-mediated aggregation of human platelets through calcium influx. Biochem. Mol. Biol. Int. 38, 1135-1141.
    • (1996) Biochem. Mol. Biol. Int. , vol.38 , pp. 1135-1141
    • Shah, B.H.1    Shamim, G.2    Khan, S.3    Saeed, S.A.4
  • 19
    • 34548511124 scopus 로고    scopus 로고
    • Rottlerin: An inappropriate and ineffective inhibitor of PKC δ
    • Soltoff, S. P. (2007) Rottlerin: an inappropriate and ineffective inhibitor of PKC δ. Trends Pharmacol. Sci. 28, 453-458.
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 453-458
    • Soltoff, S.P.1
  • 20
    • 0141593511 scopus 로고    scopus 로고
    • The protein kinase C inhibitor RO 318220 potentiates thrombin-stimulated platelet-supported prothrombinase activity
    • London, F. S. (2003) The protein kinase C inhibitor RO 318220 potentiates thrombin-stimulated platelet-supported prothrombinase activity. Blood 102, 2472-2481.
    • (2003) Blood , vol.102 , pp. 2472-2481
    • London, F.S.1
  • 21
    • 34147170380 scopus 로고    scopus 로고
    • Dual role of platelet protein kinase C in thrombus formation: Stimulation of pro-aggregatory and suppression of procoagulant activity in platelets
    • Strehl, A., Munnix, I. C., Kuijpers, M. J., van der Meijden, P. E., Cosemans, J. M., Feijqe, M. A., Nieswandt, B. and Heemskerk, J. W. (2007) Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets. J. Biol. Chem. 282, 7046-7055.
    • (2007) J. Biol. Chem. , vol.282 , pp. 7046-7055
    • Strehl, A.1    Munnix, I.C.2    Kuijpers, M.J.3    van der Meijden, P.E.4    Cosemans, J.M.5    Feijqe, M.A.6    Nieswandt, B.7    Heemskerk, J.W.8
  • 22
    • 15944385972 scopus 로고    scopus 로고
    • Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways
    • Dorsam, R. T., Kim, S., Murugappan, S., Rachoor, S., Shanker, H., Jin, J. and Kunapuli, S. P. (2005) Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways. Blood 105, 2749-2756.
    • (2005) Blood , vol.105 , pp. 2749-2756
    • Dorsam, R.T.1    Kim, S.2    Murugappan, S.3    Rachoor, S.4    Shanker, H.5    Jin, J.6    Kunapuli, S.P.7
  • 24
    • 38349188189 scopus 로고    scopus 로고
    • The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation
    • Yin, H., Stojanovic, A., Hay, N. and Du, X. (2008) The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. Blood 111, 658-665.
    • (2008) Blood , vol.111 , pp. 658-665
    • Yin, H.1    Stojanovic, A.2    Hay, N.3    Du, X.4
  • 25
    • 0036113619 scopus 로고    scopus 로고
    • Roles for both cyclic GMP and cyclic AMP in the inhibition of collagen-induced late-let aggregation by nitroprusside
    • Jang, E. K., Azzam, J. E., Dickinson, N. T., Davidson, M. M. and Haslam, R. J. (2002) Roles for both cyclic GMP and cyclic AMP in the inhibition of collagen-induced late-let aggregation by nitroprusside. Br. J. Haemotol. 117, 664-675.
    • (2002) Br. J. Haemotol. , vol.117 , pp. 664-675
    • Jang, E.K.1    Azzam, J.E.2    Dickinson, N.T.3    Davidson, M.M.4    Haslam, R.J.5
  • 26
    • 0022355509 scopus 로고
    • Alpha 2-adrenoceptor coupling to adenylate cyclase in adrenaline insensitive human platelet
    • Swart, S. S., Maguire, M., Wood, J. K. and Barnett, D. B. (1985) Alpha 2-adrenoceptor coupling to adenylate cyclase in adrenaline insensitive human platelet. Eur. J. Pharmacol. 116, 113-119.
    • (1985) Eur. J. Pharmacol. , vol.116 , pp. 113-119
    • Swart, S.S.1    Maguire, M.2    Wood, J.K.3    Barnett, D.B.4
  • 27
    • 0030966650 scopus 로고    scopus 로고
    • Signal transduction system in epinephrine stimulated platelets; comparison between epinephrine sensitive and insensitive platelets
    • Nakamura, T., Ariyoshi, H., Kambayashi, J., Ikeda, M., Shinoki, N., Kawasaki, T. and Monden, M. (1997) Signal transduction system in epinephrine stimulated platelets; comparison between epinephrine sensitive and insensitive platelets. Throm. Res. 85, 83-93.
    • (1997) Throm. Res. , vol.85 , pp. 83-93
    • Nakamura, T.1    Ariyoshi, H.2    Kambayashi, J.3    Ikeda, M.4    Shinoki, N.5    Kawasaki, T.6    Monden, M.7
  • 29
    • 0001849290 scopus 로고    scopus 로고
    • Platelet preparation and estimation of functional response
    • (Watson, S. P. and Authi, K. S., eds.), Press at Oxford University Press, New York, USA
    • McNicol A. (1996) Platelet preparation and estimation of functional response; in Platelets-A Practical Approach. (Watson, S. P. and Authi, K. S., eds.), pp 1-13, Press at Oxford University Press, New York, U.S.A.
    • (1996) Platelets-A Practical Approach , pp. 1-13
    • McNicol, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.