Rab small GTPase emerges as a regulator of TOR complex 2

Small GTPases

Volumn 1, Issue 3, 2010, Pages 180-182

  Tatebe, Hisashi ^a   Shiozaki, Kazuhiro ^a,b  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Akt; Fission yeast; Gad8; Phosphorylation; Rab6; RabGTPase; Ryh1; Schizosaccharomyces pombe; TOR

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; RAB PROTEIN; RHEB PROTEIN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; ENZYME ACTIVITY; EUKARYOTE; GENETIC CONSERVATION; NONHUMAN; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; STIMULUS;

EUKARYOTA; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 79952044837     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.1.3.14936     Document Type: Article

References (23)

1. Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991; 253:905-9; PMID: 1715094.
2. Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84; PMID: 16469695; DOI: 10.1016/j.cell.2006.01.016.
3. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-101; PMID: 15718470; DOI: 10.1126/science.1106148.
4. Hresko RC, Mueckler M. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3- L1 adipocytes. J Biol Chem 2005; 280:40406-16; PMID: 16221682; DOI: 10.1074/jbc.M508361200.
5. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129:1261-74; PMID: 17604717; DOI: 10.1016/j.cell.2007.06.009.
6. Ikeda K, Morigasaki S, Tatebe H, Tamanoi F, Shiozaki K. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 2008; 7:358-64; PMID: 18235227.
7. Tatebe H, Morigasaki S, Murayama S, Zeng CT, Shiozaki K. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr Biol 2010; 20:1975-82; PMID: 21035342; DOI: 10.1016/j. cub.2010.10.026.
8. Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, Kokubu A, et al. Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 2007; 12:1357-70; PMID: 18076573; DOI:10.1111/j.1365-2443.2007.01141.x.
9. Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M. Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol 2007; 27:3154-64; PMID: 17261596; DOI: 10.1128/MCB.01039-06.
10. Cybulski N, Hall MN. TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 2009; 34:620-7; PMID: 19875293; DOI: 10.1016/j. tibs.2009.09.004.
11. Matsuo T, Kubo Y, Watanabe Y, Yamamoto M. Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J 2003; 22:3073-83; PMID: 12805221; DOI: 10.1093/emboj/cdg298.
12. Kawai M, Nakashima A, Ueno M, Ushimaru T, Aiba K, Doi H, et al. Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity and high temperature. Curr Genet 2001; 39:166-74; PMID: 11409178.
13. +, is required for the response to starvation and other stresses via a conserved serine. J Biol Chem 2001; 276:7027-32; PMID: 11096119; DOI:10.1074/jbc.M010446200.
14. 1 cell cycle arrest in fission yeast. EMBO J 1998; 17:5388-99; PMID: 9736616; DOI: 10.1093/ emboj/17.18.5388.
15. Kim DU, Hayles J, Kim D, Wood V, Park HO, Won M, et al. Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol 2010; 28:617-23; PMID: 20473289; DOI: 10.1038/nbt.1628.
16. Hengst L, Lehmeier T, Gallwitz D. The ryh1 gene in the fission yeast Schizosaccharomyces pombe encoding a GTP-binding protein related to ras, rho and ypt: structure, expression and identification of its human homologue. EMBO J 1990; 9:1949-55; PMID: 2112088.
17. Siniossoglou S, Peak-Chew SY, Pelham HR. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. EMBO J 2000; 19:4885-94; PMID: 10990452; DOI: 10.1093/emboj/19.18.4885.
18. He Y, Sugiura R, Ma Y, Kita A, Deng L, Takegawa K, et al. Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway. Genes Cells 2006; 11:207-21; PMID: 16483310; DOI: 10.1111/j.1365-2443.2006.00935.x.
19. Grosshans BL, Ortiz D, Novick P. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA 2006; 103:11821-7; PMID: 16882731; DOI: 10.1073/pnas.0601617103.
20. Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J 2007; 405:513-22; PMID: 17461779; DOI: 10.1042/BJ20070540.
21. Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jenö P, et al. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS ONE 2007; 2:1217; PMID: 18030348; DOI:10.1371/journal.pone.0001217.
22. Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, et al. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling. J Biol Chem 2007; 282:25604-12; PMID: 17599906; DOI: 10.1074/jbc.M704343200.
23. Zerial M, McBride H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2001; 2:107-17; PMID: 11252952; DOI: 10.1038/35052055.