Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-α-positive and -negative breast cancer cells

Environmental Health Perspectives

Volumn 117, Issue 2, 2009, Pages 175-180

  LaPensee, Elizabeth W ^a   Tuttle, Traci R ^a   Fox, Sejal R ^a   Ben Jonathan, Nira ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bisphenol A; Breast cancer cells; Chemotherapeutic agents; Cytotoxicity; Estrogen receptors

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4,4' ISOPROPYLIDENEDIPHENOL; CISPLATIN; DOXORUBICIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 30; PROTEIN BCL 2; SURVIVIN; UNCLASSIFIED DRUG; VINBLASTINE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL TYPE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HEALTH HAZARD; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG INTERACTIONS; DRUG RESISTANCE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HUMANS; PHENOLS; VINBLASTINE;

EID: 60749131721     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11788     Document Type: Article

References (39)

1. Ariazi EA, Jordan VC. 2006. Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr Top Med Chem 6:203-215.
2. Aubel-Sadron G, Londos-Gagliardi D. 1984. Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 66:333-352.
3. Brockmoller J, Cascorbi I, Henning S, Meisel C, Roots I. 2000. Molecular genetics of cancer susceptibility. Pharmacology 61:212-227.
4. Chen X, Carystinos GD, Batist G. 1998. Potential for selective modulation of glutathione in cancer chemotherapy. Chem Biol Interact 111-112:263-275.
5. Dairkee SH, Seok J, Champion S, Sayeed A, Mindrinos M, Xiao W, et al. 2008. Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. Cancer Res 68:2076-2080.
6. Diel P, Olff S, Schmidt S, Michna H. 2002. Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol 80:61-70.
7. Fan M, Bigsby RM, Nephew KP. 2003. The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells. Mol Endocrinol 17:356-365.
8. Fernandez MF, Arrebola JP, Taoufiki J, Navalon A, Ballesteros O, Pulgar R, et al. 2007. Bisphenol-A and chlorinated derivatives in adipose tissue of women. Reprod Toxicol 24(2):259-264.
9. Han B, Zhang JT. 2004. Multidrug resistance in cancer chemotherapy and xenobiotic protection mediated by the half ATP-binding cassette transporter ABCG2. Curr Med Chem Anticancer Agents 4:31-42.
10. Hiroi H, Tsutsumi O, Momoeda M, Takai Y, Osuga Y, Taketani Y. 1999. Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta. Endocr J 46:773-778.
11. Huang Y, Ray S, Reed JC, Ibrado AM, Tang C, Nawabi A, et al. 1997. Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells. Breast Cancer Res Treat 42:73-81.
12. Hugo ER, Brandebourg TD, Comstock CE, Gersin KS, Sussman JJ, Ben-Jonathan N. 2006. LS14: a novel human adipocyte cell line that produces prolactin. Endocrinology 147:306-313.
13. Huppunen J, Aarnisalo P. 2004. Dimerization modulates the activity of the orphan nuclear receptor ERRgamma. Biochem Biophys Res Commun 314:964-970.
14. Keri RA, Ho SM, Hunt PA, Knudsen KE, Soto AM, Prins GS. 2007. An evaluation of evidence for the carcinogenic activity of bisphenol A. Reprod Toxicol 24:240-252.
15. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, et al. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139:4252-4263.
16. Kuruto-Niwa R, Tateoka Y, Usuki Y, Nozawa R. 2007. Measurement of bisphenol A concentrations in human colostrum. Chemosphere 66:1160-1164.
17. Le HH, Carlson EM, Chua JP, Belcher SM. 2008. Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol Lett 176:149-156.
18. Long X, Nephew KP. 2006. Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-alpha. J Biol Chem 281:9607-9615.
19. Marshall OJ. 2004. PerlPrimer: cross-platform, graphical primer design for standard, bisulphite and real-time PCR. Bioinformatics 20(15):2471-2472.
20. Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, et al. 2007. Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. J Biochem 142:517-524.
21. National Center for Biotechnology Information. 2008. GenBank Overview. Available: http://www.ncbi.nlm.nih.gov/Genbank/ [accessed 18 December 2008].
22. Okada H, Tokunaga T, Liu X, Takayanagi S, Matsushima A, Shimohigashi Y. 2008. Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma. Environ Health Perspect 116:32-38.
23. Olsen CM, Meussen-Elholm ET, Samuelsen M, Holme JA, Hongslo JK. 2003. Effects of the environmental oestrogens bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A, 4-hydroxybiphenyl and 4,4′-dihydroxybiphenyl on oestrogen receptor binding, cell proliferation and regulation of oestrogen sensitive proteins in the human breast cancer cell line MCF-7. Pharmacol Toxicol 92:180-188.
24. Pfaffl MW, Horgan GW, Dempfle L. 2002. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30:e36.
25. Prins GS, Birch L, Tang WY, Ho SM. 2007. Developmental estrogen exposures predispose to prostate carcinogenesis with aging. Reprod Toxicol 23:374-382.
26. Prossnitz ER, Arterburn JB, Sklar LA. 2007. GPR30: A G protein-coupled receptor for estrogen. Mol Cell Endocrinol 265-266:138-142.
27. Razandi M, Pedram A, Levin ER. 2000. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol Endocrinol 14:1434-1447.
28. Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D. 2002. Problems for risk assessment of endocrine-active estrogenic compounds. Environ Health Perspect 110(suppl 6):925-929.
29. Samuelsen M, Olsen C, Holme JA, Meussen-Elholm E, Bergmann A, Hongslo JK. 2001. Estrogen-like properties of brominated analogs of bisphenol A in the MCF-7 human breast cancer cell line. Cell Biol Toxicol 17:139-151.
30. Singleton DW, Feng Y, Yang J, Puga A, Lee AV, Khan SA. 2006. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ Res 100:86-92.
31. Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. 1995. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 103(suppl 7):113-122.
32. Soto AM, Vandenberg LN, Maffini MV, Sonnenschein C. 2008. Does breast cancer start in the womb? Basic Clin Pharmacol Toxicol 102:125-133.
33. Stewart DJ. 2007. Mechanisms of resistance to cisplatin and carboplatin. Crit Rev Oncol Hematol 63:12-31.
34. Teixeira C, Reed JC, Pratt MA. 1995. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 55:3902-3907.
35. Thomas P, Dong J. 2006. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol 102:175-179.
36. Tirro E, Consoli ML, Massimino M, Manzella L, Frasca F, Sciacca L, et al. 2006. Altered expression of c-IAP1, survivin, and Smac contributes to chemotherapy resistance in thyroid cancer cells. Cancer Res 66:4263-4272.
37. Toso RJ, Jordan MA, Farrell KW, Matsumoto B, Wilson L. 1993. Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine. Biochemistry 32:1285-1293.
38. Watson CS, Bulayeva NN, Wozniak AL, Finnerty CC. 2005. Signaling from the membrane via membrane estrogen receptor-alpha: estrogens, xenoestrogens, and phytoestrogens. Steroids 70:364-371.
39. Welshons WV, Nagel SC, Vom Saal FS. 2006. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 147:S56-S69.