Effects of weaning and syndyphalin-33 on expression of melanocortinergic appetite-regulating genes in swine

Domestic Animal Endocrinology

Volumn 40, Issue 3, 2011, Pages 165-172

  Cooper, T A ^a   Jenkins, S J ^a   Wojakiewicz, L ^a   Kattesh, H G ^a   Kojima, C J ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Appetite; Melanocortin; Opioid; Pig; Stress; Weaning

Indexed keywords

AGOUTI RELATED PROTEIN; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; MU OPIATE RECEPTOR; OLIGOPEPTIDE; SYNDYPHALIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMISTRY; EATING; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HYPOTHALAMUS; MALE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUCKLING; SWINE; WEANING;

AGOUTI-RELATED PROTEIN; ANIMALS; ANIMALS, SUCKLING; EATING; FEMALE; GENE EXPRESSION REGULATION; HYPOTHALAMUS; MALE; OLIGOPEPTIDES; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, OPIOID, MU; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE; WEANING;

OVIS ARIES; SUIDAE;

EID: 79952037634     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2010.11.001     Document Type: Article

References (41)

1. Kiso Y., Miyazaki T., Akita T., Moritoki H., Takei M., Nakamura H. Syndyphalin-33, a synthetic tripeptide alkylamide with prolonged analgesic activity. FEBS Lett 1981, 136(1):101-104.
2. Buonomo F.C., Tou J.S., Kaempfe L.A. Stimulation of somatotropin secretion following peripheral administration of the tripeptide, syndyphalin 33 in sheep, pigs and rats. Life Sci 1991, 48(20):1953-1961.
3. Obese F.Y., Whitlock B.K., Steele B.P., Buonomo F.C., Sartin J.L. Long-term feed intake regulation in sheep is mediated by opioid receptors. J Anim Sci 2007, 85(1):111-117.
4. Matteri R.L., Dyer C.J., Touchette K.J., Carroll J.A., Allee G.L. Effects of weaning on somatotrophic gene expression and circulating levels of insulin-like growth factor-1 (IGF-1) and IGF-2 in pigs. Domest Anim Endocrinol 2000, 19(4):247-259.
5. Kojima C.J., Carroll J.A., Matteri R.L., Touchette K.J., Allee G.L. Effects of weaning and weaning weight on neuroendocrine regulators of feed intake in pigs. J Anim Sci 2007, 85(9):2133-2139.
6. Kojima C.J., Kattesh H.G., Roberts M.P., Sun T. Physiological and immunological responses to weaning and transport in the young pig: modulation by administration of porcine somatotropin. J Anim Sci 2008, 86(11):2913-2919.
7. Kojima C.J., Jenkins S.J., Cooper T.A., Roberts M.P., Carroll J.A., Kattesh H.G. Effects of syndyphalin-33 on feed intake and circulating measures of growth hormone, cortisol, and immune cell populations in the recently-weaned pig. J Anim Sci 2009, 87(10):3218-3225.
8. Hagan M.M., Rushing P.A., Benoit S.C., Woods S.C., Seeley R.J. Opioid receptor involvement in the effect of AgRP- (83-132) on food intake and food selection. Am J Physiol Regul Integr Comp Physiol 2001, 280(3):R814-R821.
9. Brugman S.D., Clegg D.J., Woods S.C., Seeley R.J. Combined blockade of both micro- and kappa-opioid receptors prevents the acute orexigenic action of Agouti-related protein. Endocrinology 2002, 143(11):4265-4270.
10. Wardlaw S.L., Kim J., Sobieszczyk S. Effect of morphine on proopiomelanocortin gene expression and peptide levels in the hypothalamus. Brain Res Mol Brain Res 1996, 41(1-2):140-147.
11. Chaki S., Okuyama S. Involvement of melanocortin-4 receptor in anxiety and depression. Peptides 2005, 26(10):1952-1964.
12. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29(9):e45.
13. Stürzenbaum S.R., Kille P. Control genes in quantitative molecular biological techniques: the variability of invariance. Comp Biochem Physiol B Biochem Mol Biol 2001, 130(3):281-289.
14. Zhou J., Zhao R., Wei X., Xia D., Xu Q., Chen J. Developmental patterns of serum leptin levels, leptin gene expression in adipose tissue and Ob-Rb gene expression in hypothalamus of Erhualian and Large White pigs. Sci China C Life Sci 2004, 47(2):190-196.
15. Sellayah D., Sek K., Anthony F.W., Hanson M.A., Cagampang F.R. Sensitivity of housekeeping genes in the hypothalamus to mismatch in diets between pre- and postnatal periods in mice. Neurosci Lett 2008, 447(1):54-57.
16. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
17. Bark L.J., Crenshaw T.D., Leibbrandt V.D. The effect of meal intervals and weaning on feed intake of early weaned pigs. J Anim Sci 1986, 62(5):1233-1239.
18. McCracken B.A., Gaskins H.R., Ruwe-Kaiser P.J., Klasing K.C., Jewell D.E. Diet-dependent and diet-independent metabolic responses underlie growth stasis of pigs at weaning. J Nutr 1995, 125(11):2838-2845.
19. Seeger T.F., Sforzo G.A., Pert C.B., Pert A. In vivo autoradiography: visualization of stress-induced changes in opiate receptor occupancy in the rat brain. Brain Res 1984, 305(2):303-311.
20. Torda C. Effects of recurrent postnatal pain-related stressful events on opiate receptor-endogenous ligand system. Psychoneuroendocrinology 1978, 3(1):85-91.
21. Gach K., Piestrzeniewicz M., Fichna J., Stefanska B., Szemraj J., Janecka A. Opioid-induced regulation of mu-opioid receptor gene expression in the MCF-7 breast cancer cell line. Biochem Cell Biol 2008, 86(3):217-226.
22. Mansour A., Fox C.A., Akil H., Watson S.J. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 1995, 18(1):22-29.
23. Yamano Y., Yoshioka M., Toda Y., et al. Regulation of CRF, POMC and MC4R gene expression after electrical foot shock stress in the rat amygdala and hypothalamus. J Vet Med Sci 2004, 66(11):1323-1327.
24. Adan R.A., Tiesjema B., Hillebrand J.J., la Fleur S.E., Kas M.J., de Krom M. The MC4 receptor and control of appetite. Br J Pharmacol 2006, 149(7):815-827.
25. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 2005, 8(5):571-578.
26. Pritchard L.E., White A. Agouti-related protein: more than a melanocortin-4 receptor antagonist?. Peptides 2005, 26(10):1759-1770.
27. Kas M.J., Bruijnzeel A.W., Haanstra J.R., Wiegant V.M., Adan R.A. Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event. J Mol Endocrinol 2005, 35(1):159-164.
28. Barb C.R., Robertson A.S., Barrett J.B., Kraeling R.R., Houseknecht K.L. The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig. J Endocrinol 2004, 181(1):39-52.
29. Fan Z.C., Sartin J.L., Tao Y.X. Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs. Domest Anim Endocrinol 2008, 34(4):383-390.
30. Tao Y.X. The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev 2010, 31(4):506-543.
31. Hagan M.M., Rushing P.A., Pritchard L.M., Schwartz M.W., Strack A.M., Van der Ploeg L.H., Woods S.C., Seeley R.J. Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol Regul Integr Comp Physiol 2000, 279(1):R47-R52.
32. Pritchard L.E., White A. Neuropeptide processing and its impact on melanocortin pathways. Endocrinology 2007, 148(9):4201-4207.
33. Yu Y., Deng C., Huang X.F. Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice. Behav Brain Res 2009, 205(1):50-56.
34. Liu J., Garza J.C., Truong H.V., Henschel J., Zhang W., Lu X.Y. The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior. Endocrinology 2007, 148(11):5531-5540.
35. Corda M.G., Orlandi M., Fratta W. Proconflict effect of ACTH1-24: interaction with benzodiazepines. Pharmacol Biochem Behav 1990, 36(3):631-634.
36. Gonzalez M.I., Vaziri S., Wilson C.A. Behavioral effects of alpha-MSH and MCH after central administration in the female rat. Peptides 1996, 17(1):171-177.
37. Chaki S., Hirota S., Funakoshi T., et al. Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1- yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor. J Pharmacol Exp Ther 2003, 304(2):818-826.
38. Shimazaki T., Chaki S. Anxiolytic-like effect of a selective and non-peptidergic melanocortin 4 receptor antagonist, MCL0129, in a social interaction test. Pharmacol Biochem Behav 2005, 80(3):395-400.
39. Chaki S., Okubo T. Melanocortin-4 receptor antagonists for the treatment of depression and anxiety disorders. Curr Top Med Chem 2007, 7(11):1145-1151.
40. Kalin N.H., Shelton S.E., Barksdale C.M. Opiate modulation of separation-induced distress in non-human primates. Brain Res 1988, 440(2):285-292.
41. Malavasi L.M., Nyman G., Augustsson H., Jacobson M., Jensen-Waern M. Effects of epidural morphine and transdermal fentanyl analgesia on physiology and behavior after abdominal surgery in pigs. Lab Anim 2006, 40(1):16-27.