Clinically translatable cell tracking and quantification by MRI in cartilage repair using superparamagnetic iron oxides

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  van Buul, Gerben M ^a   Kotek, Gyula ^a   Wielopolski, Piotr A ^a   Farrell, Eric ^a   Bos, P Koen ^a   Weinans, Harrie ^a,b   Grohnert, Anja U ^a   Jahr, Holger ^a   Verhaar, Jan A N ^a   Krestin, Gabriel P ^a   van Osch, Gerjo J V M ^a   Bernsen, Monique R ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; SUPERPARAMAGNETIC IRON OXIDE; CONTRAST MEDIUM; DIAGNOSTIC AGENT; FERRIC ION; FERRIC OXIDE; MAGNETITE NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE; CELL ACTIVITY; CELL DEATH; CELL DIFFERENTIATION; CELL LABELING; CELL METABOLISM; CELL SECRETION; CELL TRACKING; CELL VIABILITY; CHONDROGENESIS; CONTROLLED STUDY; ENDOCYTOSIS; EX VIVO STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMAGE QUALITY; IN VITRO STUDY; IRON TRANSPORT; MESENCHYMAL STEM CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OSTEOCHONDRITIS; STEM CELL TRANSPLANTATION; SYNOVIOCYTE; TISSUE REPAIR; ANIMAL; BONE MARROW TRANSPLANTATION; CARTILAGE CELL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; EVALUATION; INTRAARTICULAR DRUG ADMINISTRATION; KNEE; MAGNETISM; MESENCHYMAL STEM CELL TRANSPLANTATION; METHODOLOGY; PHYSIOLOGY; PRODUCTIVITY; RADIOGRAPHY; REGENERATION; SWINE; TRANSLATIONAL RESEARCH;

ANIMALS; BONE MARROW TRANSPLANTATION; CARTILAGE; CELL DIFFERENTIATION; CELL TRACKING; CELLS, CULTURED; CHONDROCYTES; CONTRAST MEDIA; EFFICIENCY; FERRIC COMPOUNDS; HUMANS; INJECTIONS, INTRA-ARTICULAR; KNEE; MAGNETIC RESONANCE IMAGING; MAGNETICS; MAGNETITE NANOPARTICLES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; REGENERATION; SWINE; TRANSLATIONAL RESEARCH;

EID: 79952018800     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017001     Document Type: Article

References (35)

1. Steinert AF, Ghivizzani SC, Rethwilm A, Tuan RS, Evans CH, et al. (2007) Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther 9: 213.
2. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, et al. (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331: 889-895.
3. van Osch GJ, Brittberg M, Dennis JE, Bastiaansen-Jenniskens YM, Erben RG, et al. (2009) Cartilage repair: past and future-lessons for regenerative medicine. J Cell Mol Med 13: 792-810.
4. Centeno CJ, Schultz JR, Cheever M, Robinson B, Freeman M, et al. (2010) Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell Res Ther 5: 81-93.
5. Wakitani S, Nawata M, Tensho K, Okabe T, Machida H, et al. (2007) Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med 1: 74-79.
6. Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, et al. (2008) Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med 36: 235-246.
7. Bulte JW, (2009) In vivo MRI cell tracking: clinical studies. AJR Am J Roentgenol 193: 314-325.
8. Caplan AI, (2007) Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 213: 341-347.
9. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, et al. (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11: 343-353.
10. Farrell E, Wielopolski P, Pavljasevic P, van Tiel S, Jahr H, et al. (2008) Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo. Biochem Biophys Res Commun 369: 1076-1081.
11. Pawelczyk E, Arbab AS, Pandit S, Hu E, Frank JA, (2006) Expression of transferrin receptor and ferritin following ferumoxides-protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging. NMR Biomed 19: 581-592.
12. Kostura L, Kraitchman DL, Mackay AM, Pittenger MF, Bulte JW, (2004) Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis. NMR Biomed 17: 513-517.
13. Henning TD, Sutton EJ, Kim A, Golovko D, Horvai A, et al. (2009) The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells. Contrast Media Mol Imaging 4: 165-173.
14. Bulte JW, Kraitchman DL, Mackay AM, Pittenger MF, (2004) Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides. Blood 104: 3410-3412; author reply 3412-3413.
15. Pawelczyk E, Jordan EK, Balakumaran A, Chaudhry A, Gormley N, et al. (2009) In vivo transfer of intracellular labels from locally implanted bone marrow stromal cells to resident tissue macrophages. PLoS One 4: e6712.
16. Kedziorek DA, Muja N, Walczak P, Ruiz-Cabello J, Gilad AA, et al. (2010) Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles. Magn Reson Med 63: 1031-1043.
17. Lee KD, (2008) Applications of mesenchymal stem cells: an updated review. Chang Gung Med J 31: 228-236.
18. Jing XH, Yang L, Duan XJ, Xie B, Chen W, et al. (2008) In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection. Joint Bone Spine 75: 432-438.
19. Kijowski R, (2010) Clinical cartilage imaging of the knee and hip joints. AJR Am J Roentgenol 195: 618-628.
20. Saldanha KJ, Doan RP, Ainslie KM, Desai TA, Majumdar S, (2010) Micrometer-sized iron oxide particle labeling of mesenchymal stem cells for magnetic resonance imaging-based monitoring of cartilage tissue engineering. Magn Reson Imaging.
21. van Tiel ST, Wielopolski PA, Houston GC, Krestin GP, Bernsen MR, (2010) Variations in labeling protocol influence incorporation, distribution and retention of iron oxide nanoparticles into human umbilical vein endothelial cells. Contrast Media Mol Imaging 5: 247-257.
22. Arbab AS, Bashaw LA, Miller BR, Jordan EK, Lewis BK, et al. (2003) Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging. Radiology 229: 838-846.
23. Rad AM, Arbab AS, Iskander AS, Jiang Q, Soltanian-Zadeh H, (2007) Quantification of superparamagnetic iron oxide (SPIO)-labeled cells using MRI. J Magn Reson Imaging 26: 366-374.
24. Politi LS, Bacigaluppi M, Brambilla E, Cadioli M, Falini A, et al. (2007) Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis. Stem Cells 25: 2583-2592.
25. van Buul GM, Farrell E, Kops N, van Tiel ST, Bos PK, et al. (2009) Ferumoxides-protamine sulfate is more effective than ferucarbotran for cell labeling: implications for clinically applicable cell tracking using MRI. Contrast Media Mol Imaging 4: 230-236.
26. Farrell E, Wielopolski P, Pavljasevic P, Kops N, Weinans H, et al. (2009) Cell labelling with superparamagnetic iron oxide has no effect on chondrocyte behaviour. Osteoarthritis Cartilage 17: 961-967.
27. Chanda D, Kumar S, Ponnazhagan S, (2010) Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton. J Cell Biochem.
28. Das RH, van Osch GJ, Kreukniet M, Oostra J, Weinans H, et al. (2010) Effects of individual control of pH and hypoxia in chondrocyte culture. J Orthop Res 28: 537-545.
29. de Mos M, Koevoet WJ, Jahr H, Verstegen MM, Heijboer MP, et al. (2007) Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study. BMC Musculoskelet Disord 8: 16.
30. Montet-Abou K, Montet X, Weissleder R, Josephson L, (2005) Transfection agent induced nanoparticle cell loading. Mol Imaging 4: 165-171.
31. Hellingman CA, Koevoet W, Kops N, Farrell E, Jahr H, et al. (2009) Fibroblast Growth Factor Receptors in in-Vitro and in-Vivo Chondrogenesis: Relating Tissue Engineering Using Adult Mesenchymal Stem Cells to Embryonic Development. Tissue Eng Part A.
32. Bos PK, van Osch GJ, Frenz DA, Verhaar JA, Verwoerd-Verhoef HL, (2001) Growth factor expression in cartilage wound healing: temporal and spatial immunolocalization in a rabbit auricular cartilage wound model. Osteoarthritis Cartilage 9: 382-389.
33. Hauselmann HJ, Aydelotte MB, Schumacher BL, Kuettner KE, Gitelis SH, et al. (1992) Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. Matrix 12: 116-129.
34. Uitterlinden EJ, Jahr H, Koevoet JL, Jenniskens YM, Bierma-Zeinstra SM, et al. (2006) Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis Cartilage 14: 250-257.
35. Bastiaansen-Jenniskens YM, Koevoet W, Feijt C, Bos PK, Verhaar JA, et al. (2009) Proteoglycan production is required in initial stages of new cartilage matrix formation but inhibits integrative cartilage repair. J Tissue Eng Regen Med 3: 117-123.