Ferumoxides-protamine sulfate is more effective than ferucarbotran for cell labeling: Implications for clinically applicable cell tracking using MRI

Contrast Media and Molecular Imaging

Volumn 4, Issue 5, 2009, Pages 230-236

  Van Buul, G M ^a   Farrell, E ^a   Kops, N ^a   Van Tiel, S T ^a   Bos, P K ^a   Weinans, H ^a   Krestin, G P ^a   Van Osch, G J V M ^a   Bernsen, M R ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Cell tracking; Chondrocyte; Ferumoxides; Iron oxide labeling; MRI; MSC; Protamine sulfate; SPIO labeling

Indexed keywords

FERUCARBOTRAN; PROTAMINE SULFATE; SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; BONE MARROW CELL; CARTILAGE CELL; CELL LABELING; CELL TYPE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; INTERNALIZATION; IRON TRANSPORT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; STROMA CELL;

BONE MARROW CELLS; EXTRACELLULAR SPACE; FERROSOFERRIC OXIDE; HUMANS; INTRACELLULAR SPACE; IRON; MAGNETIC RESONANCE IMAGING; PROTAMINES; STAINING AND LABELING; STROMAL CELLS;

EID: 71649095690     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.289     Document Type: Article

References (26)

1. de Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJ, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JW, Scheenen TW, Punt CJ, Heerschap A, Figdor CG. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat. Biotechnol. 2005; 23(11): 1407-1413.
2. Zhu J, Zhou L, XingWu F. Tracking neural stem cells in patients with brain trauma. New Engl. J. Med. 2006; 355(22): 2376-2378.
3. Toso C, Vallee JP, Morel P, Ris F, Demuylder-Mischler S, Lepetit- Coiffe M, Marangon N, Saudek F, James Shapiro AM, Bosco D, Berney T. Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling. Am. J. Transplant. 2008; 8(3): 701-706.
4. Hsiao JK, Tai MF, Chu HH, Chen ST, Li H, Lai DM, Hsieh ST, Wang JL, Liu HM. Magnetic nanoparticle labeling of mesenchymal stem cells without transfection agent: cellular behavior and capability of detection with clinical 1.5 T magnetic resonance at the single cell level. Magn. Reson. Med. 2007; 58(4): 717-724.
5. Mailander V, Lorenz MR, Holzapfel V, Musyanovych A, Fuchs K, Wiesneth M, Walther P, Landfester K, Schrezenmeier H. Carboxylated superparamagnetic iron oxide particles label cells intracellularly without transfection agents. Mol. Imag. Biol. 2008; 10(3): 138-146.
6. Kustermann E, Himmelreich U, Kandal K, Geelen T, Ketkar A, Wiedermann D, Strecker C, Esser J, Arnhold S, Hoehn M. Efficient stem cell labeling for MRI studies. Contrast Media Mol. Imag. 2008; 3(1): 27-37.
7. Pawelczyk E, Arbab AS, Pandit S, Hu E, Frank JA. Expression of transferrin receptor and ferritin following ferumoxides- protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging. NMR Biomed. 2006; 19(5): 581-592. (Pubitemid 44240784)
8. He G, Zhang H,Wei H,Wang Y, Zhang X, Tang Y,Wei Y, Hu S. In vivo imaging of bone marrow mesenchymal stem cells transplanted into myocardium using magnetic resonance imaging: a novel method to trace the transplanted cells. Int. J. Cardiol. 2007; 114(1): 4-10.
9. Schafer R, Kehlbach R, Wiskirchen J, Bantleon R, Pintaske J, Brehm BR, Gerber A, Wolburg H, Claussen CD, Northoff H. Transferrin receptor upregulation: in vitro labeling of rat mesenchymal stem cells with superparamagnetic iron oxide. Radiology 2007; 244(2): 514-523. (Pubitemid 47080884)
10. Verdijk P, Scheenen TW, Lesterhuis WJ, Gambarota G, Veltien AA, Walczak P, Scharenborg NM, Bulte JW, Punt CJ, Heerschap A, Figdor CG, de Vries IJ. Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines. Int. J. Cancer 2007; 120(5): 978-984. (Pubitemid 46214296)
11. Frank JA, Miller BR, Arbab AS, Zywicke HA, Jordan EK, Lewis BK, Bryant LH Jr, Bulte JW. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 2003; 228(2): 480-487.
12. Arbab AS, Yocum GT, Rad AM, Khakoo AY, Fellowes V, Read EJ, Frank JA. Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells. NMR Biomed. 2005; 18(8): 553-559. (Pubitemid 43013896)
13. Pawelczyk E, Arbab AS, Chaudhry A, Balakumaran A, Robey PG, Frank JA. In vitro model of bromodeoxyuridine or iron oxide nanoparticle uptake by activated macrophages from labeled stem cells: implications for cellular therapy. Stem Cells 2008; 26(5): 1366-1375.
14. Omidkhoda A, Mozdarani H, Movasaghpoor A, Fatholah AA. Study of apoptosis in labeled mesenchymal stem cells with superparamagnetic iron oxide using neutral comet assay. Toxicol. in Vitro 2007; 21(6): 1191-1196. (Pubitemid 47238234)
15. Montet-Abou K, Montet X, Weissleder R, Josephson L. Cell internalization of magnetic nanoparticles using transfection agents. Mol. Imag. 2007; 6(1): 1-9.
16. Janic B, Rad AM, Jordan EK, Iskander AS, Ali MM, Varma NR, Frank JA, Arbab AS. Optimization and validation of FePro cell labeling method. PLoS One 2009; 4(6): e5873.
17. Montet-Abou K, Montet X, Weissleder R, Josephson L. Transfection agent induced nanoparticle cell loading. Mol. Imag. 2005; 4(3): 165-171.
18. Lorenz MR, Holzapfel V, Musyanovych A, Nothelfer K, Walther P, Frank H, Landfester K, Schrezenmeier H, Mailander V. Uptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cells. Biomaterials 2006; 27(14): 2820-2828. (Pubitemid 43165751)
19. Ogris M, Steinlein P, Kursa M, Mechtler K, Kircheis R,Wagner E. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 1998; 5(10): 1425-1433. (Pubitemid 28482671)
20. van der Aa MA, Huth US, Hafele SY, Schubert R, Oosting RS, Mastrobattista E, Hennink WE, Peschka-Suss R, Koning GA, Crommelin DJ. Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells. Pharm. Res. 2007; 24(8): 1590-1598.
21. Arbab AS, Yocum GT, Kalish H, Jordan EK, Anderson SA, Khakoo AY, Read EJ, Frank JA. Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 2004; 104(4): 1217-1223. (Pubitemid 39038047)
22. Rad AM, Janic B, Iskander AS, Soltanian-Zadeh H, Arbab AS. Measurement of quantity of iron in magnetically labeled cells: comparison among different UV/VIS spectrometric methods. Biotechniques 2007; 43(5): 627-628 630, 632 passim. (Pubitemid 350174913)
23. Otero-Romani J, Moreda-Pineiro A, Bermejo-Barrera P, Martin- Esteban A. Inductively coupled plasma-optical emission spectrometry/ mass spectrometry for the determination of Cu, Ni, Pb and Zn in seawater after ionic imprinted polymer based solid phase extraction. Talanta 2009; 79(3): 723-729.
24. Farrell E, Wielopolski P, Pavljasevic P, Kops N, Weinans H, Bernsen MR, van Osch GJ. Cell labelling with superparamagnetic iron oxide has no effect on chondrocyte behaviour. Osteoarthritis Cartilage 2009; 17(7): 958-964.
25. de Mos M, Koevoet WJ, Jahr H, Verstegen MM, Heijboer MP, Kops N, van Leeuwen JP, Weinans H, Verhaar JA, van Osch GJ. Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study. BMC Musculoskelet. Disord. 2007; 8: 16.
26. Das RH, Jahr H, Verhaar JA, van der Linden JC, van Osch GJ, Weinans H. In vitro expansion affects the response of chondrocytes to mechanical stimulation. Osteoarthritis Cartilage 2008; 16(3): 385-391.