-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin D.M., Bray F., Ferlay J., et al. Global cancer statistics, 2002. Ca Cancer J Clin 2005, 55:74-108.
-
(2005)
Ca Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
-
2
-
-
0036291076
-
Epidemiology, risk factors and natural history of hepatocellular carcinoma
-
Montalto G., Cervello M., Giannitrapani L., et al. Epidemiology, risk factors and natural history of hepatocellular carcinoma. Ann NY Acad Sci 2002, 963:13-20.
-
(2002)
Ann NY Acad Sci
, vol.963
, pp. 13-20
-
-
Montalto, G.1
Cervello, M.2
Giannitrapani, L.3
-
3
-
-
55949086924
-
Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis
-
Gomaa A.I., Khan S.A., Toledano M.B., et al. Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol 2008, 14(27):4300-4308.
-
(2008)
World J Gastroenterol
, vol.14
, Issue.27
, pp. 4300-4308
-
-
Gomaa, A.I.1
Khan, S.A.2
Toledano, M.B.3
-
4
-
-
0036210852
-
The rise and fall in primary liver cancer mortality in Italy
-
La Vecchia C., Negri E., Pelucchi C. The rise and fall in primary liver cancer mortality in Italy. Digestive Liver Dis 2002, 34:169-171.
-
(2002)
Digestive Liver Dis
, vol.34
, pp. 169-171
-
-
La Vecchia, C.1
Negri, E.2
Pelucchi, C.3
-
5
-
-
7044229778
-
Primary liver cancer: worldwide incidence and trends
-
Bosch F.X., Ribes J., Diaz M., Claries R., et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004, 127:S5-S16.
-
(2004)
Gastroenterology
, vol.127
-
-
Bosch, F.X.1
Ribes, J.2
Diaz, M.3
Claries, R.4
-
6
-
-
40949109774
-
Epidemiology of hepatocellular carcinoma in USA
-
El-Serag H.B. Epidemiology of hepatocellular carcinoma in USA. Hepatol Res 2007, 37(Suppl. 2):S88-S94.
-
(2007)
Hepatol Res
, vol.37
, Issue.SUPPL. 2
-
-
El-Serag, H.B.1
-
7
-
-
33847369349
-
Hepatocellular cancer: a guide for the internist
-
Parikh S., Hyman D. Hepatocellular cancer: a guide for the internist. Am J Med 2007, 120:194-202.
-
(2007)
Am J Med
, vol.120
, pp. 194-202
-
-
Parikh, S.1
Hyman, D.2
-
8
-
-
33845979471
-
Host immune status and incidence of hepatocellular carcinoma among subject infected with hepatitis C virus: a nested case-control study in Japan
-
Suruky R.J., Mueller N., Hayashi K., et al. Host immune status and incidence of hepatocellular carcinoma among subject infected with hepatitis C virus: a nested case-control study in Japan. Cancer Epidemiol Biomarkers Prev 2006, 15:2521-2525.
-
(2006)
Cancer Epidemiol Biomarkers Prev
, vol.15
, pp. 2521-2525
-
-
Suruky, R.J.1
Mueller, N.2
Hayashi, K.3
-
9
-
-
34248995566
-
Hepatitis B virus related hepatocellular carcinoma: epidemiology and pathogenic role of viral factors
-
Liu C.J., Kao J.H. Hepatitis B virus related hepatocellular carcinoma: epidemiology and pathogenic role of viral factors. J Chin Med Assoc 2007, 70:141-145.
-
(2007)
J Chin Med Assoc
, vol.70
, pp. 141-145
-
-
Liu, C.J.1
Kao, J.H.2
-
10
-
-
23144446812
-
Alcohol and liver cancer
-
McKillop I.H., Schrum L.W. Alcohol and liver cancer. Alcohol 2005, 35:195-203.
-
(2005)
Alcohol
, vol.35
, pp. 195-203
-
-
McKillop, I.H.1
Schrum, L.W.2
-
11
-
-
14844318557
-
Alcohol in hepatocellular cancer
-
Voigt M.D. Alcohol in hepatocellular cancer. Clin Liver Dis 2005, 9:151-169.
-
(2005)
Clin Liver Dis
, vol.9
, pp. 151-169
-
-
Voigt, M.D.1
-
12
-
-
0036302288
-
Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenetic cirrhosis to hepatocellular carcinoma
-
Bugianesi E., Leone N., Vanni E., et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenetic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002, 123:134-140.
-
(2002)
Gastroenterology
, vol.123
, pp. 134-140
-
-
Bugianesi, E.1
Leone, N.2
Vanni, E.3
-
13
-
-
70350284071
-
Diabetes mellitus: a " true" independent risk factor for hepatocellular carcinoma?
-
Chun G., Shu-Kun Y. Diabetes mellitus: a " true" independent risk factor for hepatocellular carcinoma?. Hepatobiliary Pancreat Dis Int 2009, 8:465-473.
-
(2009)
Hepatobiliary Pancreat Dis Int
, vol.8
, pp. 465-473
-
-
Chun, G.1
Shu-Kun, Y.2
-
14
-
-
70349641345
-
Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection
-
Rossi M., Lipworth L., Dal Maso L., et al. Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection. Ann Oncol 2009, 20(10):1736-1740.
-
(2009)
Ann Oncol
, vol.20
, Issue.10
, pp. 1736-1740
-
-
Rossi, M.1
Lipworth, L.2
Dal Maso, L.3
-
15
-
-
0035986529
-
Dysplastic nodules and hepatocarcinogenesis
-
Theise N.D., Park Y.N., Kojiro M. Dysplastic nodules and hepatocarcinogenesis. Clin Liver Dis 2002, 6:497-512.
-
(2002)
Clin Liver Dis
, vol.6
, pp. 497-512
-
-
Theise, N.D.1
Park, Y.N.2
Kojiro, M.3
-
16
-
-
0042093775
-
Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development
-
Borzio M., Fargion S., Borzio F., et al. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 2003, 39:208-214.
-
(2003)
J Hepatol
, vol.39
, pp. 208-214
-
-
Borzio, M.1
Fargion, S.2
Borzio, F.3
-
17
-
-
0035575999
-
Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis
-
Park Y.N., Chae K.J., Kim Y.B., Park C., Theise N. Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis. Cancer 2001, 92:2733-2738.
-
(2001)
Cancer
, vol.92
, pp. 2733-2738
-
-
Park, Y.N.1
Chae, K.J.2
Kim, Y.B.3
Park, C.4
Theise, N.5
-
18
-
-
0042669697
-
Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type
-
Nakashima Y., Nakashima O., Tanaka M., et al. Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type. Hepatol Res 2003, 26:142-147.
-
(2003)
Hepatol Res
, vol.26
, pp. 142-147
-
-
Nakashima, Y.1
Nakashima, O.2
Tanaka, M.3
-
20
-
-
0036920208
-
Cellular origin of hepatocellular carcinomas
-
Sell S. Cellular origin of hepatocellular carcinomas. Semin Cell Dev Biol 2002, 13:419-424.
-
(2002)
Semin Cell Dev Biol
, vol.13
, pp. 419-424
-
-
Sell, S.1
-
21
-
-
0037397156
-
Regulatory mechanisms of viral hepatitis B and C
-
Waris G., Siddiqui A. Regulatory mechanisms of viral hepatitis B and C. J Biosci 2003, 28:311-321.
-
(2003)
J Biosci
, vol.28
, pp. 311-321
-
-
Waris, G.1
Siddiqui, A.2
-
22
-
-
0036345943
-
Interaction between hepatitis C virus protein and host cell factors
-
Tellinghuisen T.L., Rice C.M. Interaction between hepatitis C virus protein and host cell factors. Curr Opin Microbiol 2002, 5:419-427.
-
(2002)
Curr Opin Microbiol
, vol.5
, pp. 419-427
-
-
Tellinghuisen, T.L.1
Rice, C.M.2
-
23
-
-
0042968962
-
Molecular viral oncology of hepatocellular carcinoma
-
Block T.M., Mehta A.S., Fimmel C.J., et al. Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003, 22:5093-5107.
-
(2003)
Oncogene
, vol.22
, pp. 5093-5107
-
-
Block, T.M.1
Mehta, A.S.2
Fimmel, C.J.3
-
24
-
-
0035799529
-
Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein
-
Giambartolomei S., Covone F., Levrero M., et al. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene 2001, 20:2606-2610.
-
(2001)
Oncogene
, vol.20
, pp. 2606-2610
-
-
Giambartolomei, S.1
Covone, F.2
Levrero, M.3
-
26
-
-
0033655446
-
Regulation of glutathione synthesis
-
Lu S.C. Regulation of glutathione synthesis. Cur Top Cell Regul 2000, 36:95-116.
-
(2000)
Cur Top Cell Regul
, vol.36
, pp. 95-116
-
-
Lu, S.C.1
-
27
-
-
10844265570
-
Recent events in alcoholic liver disease. V. Effects of ethanol on liver regeneration
-
Diehl A.M. Recent events in alcoholic liver disease. V. Effects of ethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol 2005, 288:G1-G6.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.288
-
-
Diehl, A.M.1
-
28
-
-
18144411666
-
Update treatment approach to hepatocellular carcinoma
-
Llovet J.M. Update treatment approach to hepatocellular carcinoma. J Gastroenterol 2005, 40:225-235.
-
(2005)
J Gastroenterol
, vol.40
, pp. 225-235
-
-
Llovet, J.M.1
-
29
-
-
0035146422
-
A model to predict survival in patients with and-stage liver disease
-
Kamath P.S., Wiesner R.H., Malinchoc M., et al. A model to predict survival in patients with and-stage liver disease. Hepatology 2001, 33:464-470.
-
(2001)
Hepatology
, vol.33
, pp. 464-470
-
-
Kamath, P.S.1
Wiesner, R.H.2
Malinchoc, M.3
-
30
-
-
0037308133
-
Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival
-
Llovet J.M., Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 2003, 37:429-442.
-
(2003)
Hepatology
, vol.37
, pp. 429-442
-
-
Llovet, J.M.1
Bruix, J.2
-
31
-
-
0032898237
-
Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials
-
Llovet J.M., Bustamante J., Castells A., et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology 1999, 29:62-67.
-
(1999)
Hepatology
, vol.29
, pp. 62-67
-
-
Llovet, J.M.1
Bustamante, J.2
Castells, A.3
-
32
-
-
0037087696
-
Simplified staging for hepatocellular carcinoma
-
Vauthey J., Lauwers G., Esnaola N., et al. Simplified staging for hepatocellular carcinoma. J Clin Oncol 2002, 20:1527-1536.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1527-1536
-
-
Vauthey, J.1
Lauwers, G.2
Esnaola, N.3
-
34
-
-
0021965806
-
Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients
-
Okuda K., Ohtsui T., Obata H., et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985, 56:918-928.
-
(1985)
Cancer
, vol.56
, pp. 918-928
-
-
Okuda, K.1
Ohtsui, T.2
Obata, H.3
-
35
-
-
0037086560
-
Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients
-
Leung T.W., Tang A.M., Zee B., et al. Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients. Cancer 2002, 94:1760-1769.
-
(2002)
Cancer
, vol.94
, pp. 1760-1769
-
-
Leung, T.W.1
Tang, A.M.2
Zee, B.3
-
36
-
-
0034107047
-
Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma
-
CLIP
-
CLIP Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology 2000, 31:840-845.
-
(2000)
Hepatology
, vol.31
, pp. 840-845
-
-
-
37
-
-
0033066135
-
A new prognostic classification for predicting survival in patients with hepatocellular carcinoma
-
Chevret S., Trinchet J.C., Mathieu D., et al. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. J Hepatol 1999, 31:133-141.
-
(1999)
J Hepatol
, vol.31
, pp. 133-141
-
-
Chevret, S.1
Trinchet, J.C.2
Mathieu, D.3
-
38
-
-
10644225254
-
Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score
-
Kudo M., Chung H., Haji S., et al. Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score. Hepatology 2004, 40:1396-1405.
-
(2004)
Hepatology
, vol.40
, pp. 1396-1405
-
-
Kudo, M.1
Chung, H.2
Haji, S.3
-
39
-
-
39049174414
-
Modified Japan integrated staging is currently the best available staging system for hepatocellular carcinoma patients who have undergone hepatectomy
-
Nanashima A., Sumida Y., Abo T., et al. Modified Japan integrated staging is currently the best available staging system for hepatocellular carcinoma patients who have undergone hepatectomy. J Gastroenterol 2006, 41:250-256.
-
(2006)
J Gastroenterol
, vol.41
, pp. 250-256
-
-
Nanashima, A.1
Sumida, Y.2
Abo, T.3
-
40
-
-
0032879468
-
Prognosis of hepatocellular carcinoma: the BCLC staging classification
-
Llovet J.M., Bru C., Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999, 19:329-338.
-
(1999)
Semin Liver Dis
, vol.19
, pp. 329-338
-
-
Llovet, J.M.1
Bru, C.2
Bruix, J.3
-
41
-
-
33947428441
-
The model for end-stage liver disease (MELD)
-
Kamath P.S., Kim W.R. The model for end-stage liver disease (MELD). Hepatology 2007, 45:797-805.
-
(2007)
Hepatology
, vol.45
, pp. 797-805
-
-
Kamath, P.S.1
Kim, W.R.2
-
42
-
-
28844480321
-
Management of hepatocellular carcinoma. AASLD practice guideline
-
Bruix J., Sherman M. Management of hepatocellular carcinoma. AASLD practice guideline. Hepatology 2005, 42:1208-1236.
-
(2005)
Hepatology
, vol.42
, pp. 1208-1236
-
-
Bruix, J.1
Sherman, M.2
-
43
-
-
79952002527
-
Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: review of the randomized clinical trials
-
Llovet J.M., Fuster J., Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: review of the randomized clinical trials. Lancet Oncol 2002, 3:593-603.
-
(2002)
Lancet Oncol
, vol.3
, pp. 593-603
-
-
Llovet, J.M.1
Fuster, J.2
Bruix, J.3
-
44
-
-
0038714350
-
Small hepatocellular carcinoma in cirrhosis: randomized controlled trial of radiofrequency thermal ablation versus percutaneous ethanol injection
-
Lencioni R., Allagaier H.P., Cioni D., et al. Small hepatocellular carcinoma in cirrhosis: randomized controlled trial of radiofrequency thermal ablation versus percutaneous ethanol injection. Radiology 2003, 228:235-240.
-
(2003)
Radiology
, vol.228
, pp. 235-240
-
-
Lencioni, R.1
Allagaier, H.P.2
Cioni, D.3
-
45
-
-
9644265250
-
Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma of 4cm or less
-
Lin S., Lin C., Lin C., et al. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma of 4cm or less. Gastroenterology 2004, 127:1714-1723.
-
(2004)
Gastroenterology
, vol.127
, pp. 1714-1723
-
-
Lin, S.1
Lin, C.2
Lin, C.3
-
46
-
-
0031854410
-
Chemotherapy in hepatocellular carcinoma
-
Okada S. Chemotherapy in hepatocellular carcinoma. Hepatogastroenterology 1998, 45(Suppl. 3):1259-1263.
-
(1998)
Hepatogastroenterology
, vol.45
, Issue.SUPPL. 3
, pp. 1259-1263
-
-
Okada, S.1
-
47
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
Abou-Alfa G.K., Schwartz L., Ricci S., et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24:4293-4300.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
-
48
-
-
34548720158
-
SHARP investigators. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a phase III randomized placebo-controlled trial
-
Llovet J., Ricci S., Mazzaferro V., et al. SHARP investigators. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a phase III randomized placebo-controlled trial. J Clin Oncol 2007, LBA1.
-
(2007)
J Clin Oncol
-
-
Llovet, J.1
Ricci, S.2
Mazzaferro, V.3
-
49
-
-
44449085884
-
Design and endpoints of clinical trials in hepatocellular carcinoma
-
Llovet J.M., Di Bisceglie A.M., Bruix J., et al. Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst 2008, 100:698-711.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 698-711
-
-
Llovet, J.M.1
Di Bisceglie, A.M.2
Bruix, J.3
-
50
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
51
-
-
33847118123
-
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
-
Chang Y.S., Adnane J., Trail P.A., et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol 2007, 59:561-574.
-
(2007)
Cancer Chemother Pharmacol
, vol.59
, pp. 561-574
-
-
Chang, Y.S.1
Adnane, J.2
Trail, P.A.3
-
52
-
-
33847069207
-
Genomics and signaling pathways in hepatocellular carcinoma
-
Villanueva A., Newell P., Chiang D.Y., et al. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007, 27:55-76.
-
(2007)
Semin Liver Dis
, vol.27
, pp. 55-76
-
-
Villanueva, A.1
Newell, P.2
Chiang, D.Y.3
-
53
-
-
33645976174
-
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
-
Calvisi D.F., Ladu S., Gorden A., et al. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 2006, 130:1117-1128.
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
-
54
-
-
7244250405
-
Angiogenesis and hepatocellular carcinoma
-
Semela D., Dufour J.F. Angiogenesis and hepatocellular carcinoma. J Hepatol 2004, 41:864-880.
-
(2004)
J Hepatol
, vol.41
, pp. 864-880
-
-
Semela, D.1
Dufour, J.F.2
-
55
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
56
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
Liu L., Cao Y., Chen C., et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006, 66:11851-11858.
-
(2006)
Cancer Res
, vol.66
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
-
57
-
-
58049220774
-
Randomized phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma
-
Cheng A., Kang Y., Chen Z., et al. Randomized phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma. J Clin Oncol 2008, U26:4509.
-
(2008)
J Clin Oncol
, vol.U26
, pp. 4509
-
-
Cheng, A.1
Kang, Y.2
Chen, Z.3
-
58
-
-
0038204144
-
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
-
O'Farrell A.M., Abrams T.J., Yuen H.A., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003, 101:3597-3605.
-
(2003)
Blood
, vol.101
, pp. 3597-3605
-
-
O'Farrell, A.M.1
Abrams, T.J.2
Yuen, H.A.3
-
59
-
-
37149017305
-
A phase II study of sunitinib in patients with advanced hepatocellular carcinoma
-
Zhu A.X., Sahani D.V., di Tomaso E., et al. A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2007, 25:4637.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4637
-
-
Zhu, A.X.1
Sahani, D.V.2
di Tomaso, E.3
-
60
-
-
34548322506
-
Assessment of safety and drug induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC)
-
Faivre S.J., Raymond E., Douillard J., et al. Assessment of safety and drug induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). J Clin Oncol 2007, 25:3546.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3546
-
-
Faivre, S.J.1
Raymond, E.2
Douillard, J.3
-
61
-
-
34547102484
-
Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
-
Zhu A.X., Stuart K., Blaszkowsky L.S., et al. Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer 2007, 110:581-589.
-
(2007)
Cancer
, vol.110
, pp. 581-589
-
-
Zhu, A.X.1
Stuart, K.2
Blaszkowsky, L.S.3
-
62
-
-
36348947270
-
A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results
-
Gruenwald V., Wilkens L., Gebel M. A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results. J Clin Oncol 2007, 25:A4594.
-
(2007)
J Clin Oncol
, vol.25
-
-
Gruenwald, V.1
Wilkens, L.2
Gebel, M.3
-
63
-
-
27244447373
-
Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
-
Philip P.A., Mahoney M.R., Allmer C., et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005, 23:6657-6663.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6657-6663
-
-
Philip, P.A.1
Mahoney, M.R.2
Allmer, C.3
-
64
-
-
34548150925
-
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
-
Thomas M.B., Chadha R., Glover K., et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 2007, 110:1059-1067.
-
(2007)
Cancer
, vol.110
, pp. 1059-1067
-
-
Thomas, M.B.1
Chadha, R.2
Glover, K.3
-
65
-
-
33750929534
-
Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group's Study E1203
-
O'Dwyer P.J., Giantonio B.J., Levy D.E., et al. Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group's Study E1203. J Clin Oncol 2006, 24:4143.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4143
-
-
O'Dwyer, P.J.1
Giantonio, B.J.2
Levy, D.E.3
-
66
-
-
33750915657
-
Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial
-
[Abstract 4010]
-
Ramanathan R.K., Belani C.P., Singh D.A., et al. Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. J Clin Oncol (Meeting Abstracts) 2006, 24(18S). [Abstract 4010].
-
(2006)
J Clin Oncol (Meeting Abstracts)
, vol.24
, Issue.18 S
-
-
Ramanathan, R.K.1
Belani, C.P.2
Singh, D.A.3
-
67
-
-
0043163428
-
Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
-
Chao Y., Li C.P., Chau G.Y., et al. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann Surg Oncol 2003, 55-62.
-
(2003)
Ann Surg Oncol
, pp. 55-62
-
-
Chao, Y.1
Li, C.P.2
Chau, G.Y.3
-
68
-
-
4944234987
-
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
-
Poon R.T., Ho J.W., Tong C.S., et al. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br J Surg 2004, 91:1354-1360.
-
(2004)
Br J Surg
, vol.91
, pp. 1354-1360
-
-
Poon, R.T.1
Ho, J.W.2
Tong, C.S.3
-
69
-
-
46449091500
-
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
-
Siegel A.B., Cohen E.I., Ocean A., et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 2008, 26:2992-2998.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2992-2998
-
-
Siegel, A.B.1
Cohen, E.I.2
Ocean, A.3
-
70
-
-
36549072713
-
The combination of bevacizumab and erlotinib shows significant biological activity in patients with advanced hepatocellular carcinoma
-
Thomas M.B., Chadha R., Iwasaki M., et al. The combination of bevacizumab and erlotinib shows significant biological activity in patients with advanced hepatocellular carcinoma. J Clin Oncol 2007, 25:4567.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4567
-
-
Thomas, M.B.1
Chadha, R.2
Iwasaki, M.3
-
71
-
-
33750917456
-
Bevacizumab in unresectable hepatocellular carcinoma for patients without metastasis and without invasion of the portal vein
-
Schwartz J., Schwartz M., Lehrer D. Bevacizumab in unresectable hepatocellular carcinoma for patients without metastasis and without invasion of the portal vein. J Clin Oncol 2006, 24:A4144.
-
(2006)
J Clin Oncol
, vol.24
-
-
Schwartz, J.1
Schwartz, M.2
Lehrer, D.3
-
72
-
-
33646351795
-
Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
-
Zhu A.X., Blaszkowsky L.S., Ryan D.P., et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24:1898-1903.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1898-1903
-
-
Zhu, A.X.1
Blaszkowsky, L.S.2
Ryan, D.P.3
-
73
-
-
39849106728
-
Influence of hepatic dysfunction on safety, tolerability and pharmacokinetics of PTK787/ZK222584 in patients with unresectable HCC
-
Koch I., Baron A., Roberts S. Influence of hepatic dysfunction on safety, tolerability and pharmacokinetics of PTK787/ZK222584 in patients with unresectable HCC. J Clin Oncol 2005, 23:A4134.
-
(2005)
J Clin Oncol
, vol.23
-
-
Koch, I.1
Baron, A.2
Roberts, S.3
-
74
-
-
79952005818
-
NCCTG phase II trial (N044J) of AZD2171 for patients with hepatocellular carcinoma (HCC)-interim review of toxicity
-
In: Gastrointestinal cancer symposium, Orlando, FL, January 19-21, 2007 [Abstract 186].
-
Alberts SR, Morlan BW, Kim GP, et al. NCCTG phase II trial (N044J) of AZD2171 for patients with hepatocellular carcinoma (HCC)-interim review of toxicity. In: 2007 Gastrointestinal cancer symposium, Orlando, FL, January 19-21, 2007 [Abstract 186].
-
(2007)
-
-
Alberts, S.R.1
Morlan, B.W.2
Kim, G.P.3
-
75
-
-
11144236505
-
MTOR and P70 S6 kinase expression in primary liver neoplasms
-
Sahin F., Kannangai R., Adegbola O., et al. MTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004, 10:8421-8425.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8421-8425
-
-
Sahin, F.1
Kannangai, R.2
Adegbola, O.3
-
76
-
-
33846277588
-
In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin
-
Ribatti D., Nico B., Mangieri D., et al. In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin. Histol Histopathol 2007, 22:285-289.
-
(2007)
Histol Histopathol
, vol.22
, pp. 285-289
-
-
Ribatti, D.1
Nico, B.2
Mangieri, D.3
-
77
-
-
33947501692
-
Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
-
Sieghart W., Fuereder T., Schmid K., et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation 2007, 83:425-432.
-
(2007)
Transplantation
, vol.83
, pp. 425-432
-
-
Sieghart, W.1
Fuereder, T.2
Schmid, K.3
-
78
-
-
79952002694
-
-
Available at
-
Available at: http://www.cancer.gov/clinicaltrials/search.
-
-
-
-
79
-
-
1542285169
-
Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: relationship to clinicopathological factors and prognosis after hepatic resection
-
Nanashima A., Yano H., Yamaguchi H., et al. Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: relationship to clinicopathological factors and prognosis after hepatic resection. J Gastroenterol 2004, 39(2):148-154.
-
(2004)
J Gastroenterol
, vol.39
, Issue.2
, pp. 148-154
-
-
Nanashima, A.1
Yano, H.2
Yamaguchi, H.3
-
80
-
-
0034014185
-
Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma
-
Ouchi K., Sugawara T., Ono H., et al. Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma. Dig Surg 2000, 17:42-48.
-
(2000)
Dig Surg
, vol.17
, pp. 42-48
-
-
Ouchi, K.1
Sugawara, T.2
Ono, H.3
-
81
-
-
3042585770
-
Prognostic significance of Bcl-xLIto in human hepatocellular carcinoma
-
Watanabe J., Kushihata F., Honda K., et al. Prognostic significance of Bcl-xLIto in human hepatocellular carcinoma. Surgery 2004, 135(6):604-612.
-
(2004)
Surgery
, vol.135
, Issue.6
, pp. 604-612
-
-
Watanabe, J.1
Kushihata, F.2
Honda, K.3
-
82
-
-
8144225075
-
Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome
-
Fields A.C., Cotsonis G., Sexton D., et al. Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome. Mod Pathol 2004, 17:1378-1385.
-
(2004)
Mod Pathol
, vol.17
, pp. 1378-1385
-
-
Fields, A.C.1
Cotsonis, G.2
Sexton, D.3
-
83
-
-
0036793871
-
Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma
-
Ikeguci M., Ueta T., Yamane Y., et al. Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. Clin Cancer Res 2002, 8(10):3131-3136.
-
(2002)
Clin Cancer Res
, vol.8
, Issue.10
, pp. 3131-3136
-
-
Ikeguci, M.1
Ueta, T.2
Yamane, Y.3
-
84
-
-
0033870417
-
Control of apoptosis during angiogenesis by survivin expression in endothelial cells
-
O'Connor D.S., Schechner J.S., Adida C., et al. Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol 2000, 156:393-398.
-
(2000)
Am J Pathol
, vol.156
, pp. 393-398
-
-
O'Connor, D.S.1
Schechner, J.S.2
Adida, C.3
-
85
-
-
0035270901
-
Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy
-
Kobayashi T., Kubota K., Takayama T., et al. Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy. Am J Surg 2001, 181:284-288.
-
(2001)
Am J Surg
, vol.181
, pp. 284-288
-
-
Kobayashi, T.1
Kubota, K.2
Takayama, T.3
-
86
-
-
0035061942
-
Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas
-
Ohashi R., Gao C., Miyazaki M., et al. Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas. Anticancer Res 2001, 21:657-662.
-
(2001)
Anticancer Res
, vol.21
, pp. 657-662
-
-
Ohashi, R.1
Gao, C.2
Miyazaki, M.3
-
87
-
-
0033766176
-
Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma
-
Fiorentino M., Altimari A., D'Errico A., et al. Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma. Clin Cancer Res 2000, 6:3966-3972.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3966-3972
-
-
Fiorentino, M.1
Altimari, A.2
D'Errico, A.3
-
88
-
-
0038666340
-
Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas
-
Xu X., Yamamoto H., Sakon M., et al. Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas. Clin Cancer Res 2003, 9(5):1764-1772.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.5
, pp. 1764-1772
-
-
Xu, X.1
Yamamoto, H.2
Sakon, M.3
-
89
-
-
0036282936
-
P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection
-
Qin L.X., Tang Z.Y., Ma Z.C., et al. P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection. World J Gastroenterol 2002, 8(3):459-463.
-
(2002)
World J Gastroenterol
, vol.8
, Issue.3
, pp. 459-463
-
-
Qin, L.X.1
Tang, Z.Y.2
Ma, Z.C.3
-
90
-
-
0034905286
-
Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas
-
Matsumura T., Makino R., Mitamura K. Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res 2001, 7:594-599.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 594-599
-
-
Matsumura, T.1
Makino, R.2
Mitamura, K.3
-
91
-
-
0036190930
-
Expression and prognostic roles of β-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival
-
Inagawa S., Itabashi M., Adachi S., et al. Expression and prognostic roles of β-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival. Clin Cancer Res 2002, 8:450-456.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 450-456
-
-
Inagawa, S.1
Itabashi, M.2
Adachi, S.3
-
92
-
-
0033962047
-
Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival
-
Endo K., Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol 2000, 32:78-84.
-
(2000)
J Hepatol
, vol.32
, pp. 78-84
-
-
Endo, K.1
Terada, T.2
-
93
-
-
0035906821
-
Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma
-
Ito Y., Takeda T., Sakon M., et al. Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Br J Cancer 2001, 84:1377-1383.
-
(2001)
Br J Cancer
, vol.84
, pp. 1377-1383
-
-
Ito, Y.1
Takeda, T.2
Sakon, M.3
-
94
-
-
0142024103
-
Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours
-
Altimari A., Fiorentino M., Gabusi E., et al. Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours. Dig Liver Dis 2003, 35:332-338.
-
(2003)
Dig Liver Dis
, vol.35
, pp. 332-338
-
-
Altimari, A.1
Fiorentino, M.2
Gabusi, E.3
-
95
-
-
0036466854
-
Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma
-
Giannelli G., Bergamini C., Marinosci F., et al. Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma. Int J Cancer 2002, 97:425-431.
-
(2002)
Int J Cancer
, vol.97
, pp. 425-431
-
-
Giannelli, G.1
Bergamini, C.2
Marinosci, F.3
-
96
-
-
0033784038
-
Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor
-
Zheng Q., Tang Z.Y., Xue Q., et al. Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor. J Cancer Res Clin Oncol 2000, 126:641-646.
-
(2000)
J Cancer Res Clin Oncol
, vol.126
, pp. 641-646
-
-
Zheng, Q.1
Tang, Z.Y.2
Xue, Q.3
|