메뉴 건너뛰기




Volumn 37, Issue 3, 2011, Pages 169-177

Evolving strategies for the treatment of hepatocellular carcinoma: From clinical-guided to molecularly-taylored therapeutic options

Author keywords

HBx; Hepatocellular carcinoma; Molecularly targeted therapy; Sorafenib; Sunitinib

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CEDIRANIB; CETUXIMAB; DOXORUBICIN; ERLOTINIB; GEFITINIB; LAPATINIB; PLACEBO; SORAFENIB; SUNITINIB; VANDETANIB; VATALANIB;

EID: 79952008530     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2010.08.001     Document Type: Review
Times cited : (52)

References (96)
  • 2
    • 0036291076 scopus 로고    scopus 로고
    • Epidemiology, risk factors and natural history of hepatocellular carcinoma
    • Montalto G., Cervello M., Giannitrapani L., et al. Epidemiology, risk factors and natural history of hepatocellular carcinoma. Ann NY Acad Sci 2002, 963:13-20.
    • (2002) Ann NY Acad Sci , vol.963 , pp. 13-20
    • Montalto, G.1    Cervello, M.2    Giannitrapani, L.3
  • 3
    • 55949086924 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis
    • Gomaa A.I., Khan S.A., Toledano M.B., et al. Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol 2008, 14(27):4300-4308.
    • (2008) World J Gastroenterol , vol.14 , Issue.27 , pp. 4300-4308
    • Gomaa, A.I.1    Khan, S.A.2    Toledano, M.B.3
  • 4
    • 0036210852 scopus 로고    scopus 로고
    • The rise and fall in primary liver cancer mortality in Italy
    • La Vecchia C., Negri E., Pelucchi C. The rise and fall in primary liver cancer mortality in Italy. Digestive Liver Dis 2002, 34:169-171.
    • (2002) Digestive Liver Dis , vol.34 , pp. 169-171
    • La Vecchia, C.1    Negri, E.2    Pelucchi, C.3
  • 5
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: worldwide incidence and trends
    • Bosch F.X., Ribes J., Diaz M., Claries R., et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004, 127:S5-S16.
    • (2004) Gastroenterology , vol.127
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3    Claries, R.4
  • 6
    • 40949109774 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma in USA
    • El-Serag H.B. Epidemiology of hepatocellular carcinoma in USA. Hepatol Res 2007, 37(Suppl. 2):S88-S94.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 2
    • El-Serag, H.B.1
  • 7
    • 33847369349 scopus 로고    scopus 로고
    • Hepatocellular cancer: a guide for the internist
    • Parikh S., Hyman D. Hepatocellular cancer: a guide for the internist. Am J Med 2007, 120:194-202.
    • (2007) Am J Med , vol.120 , pp. 194-202
    • Parikh, S.1    Hyman, D.2
  • 8
    • 33845979471 scopus 로고    scopus 로고
    • Host immune status and incidence of hepatocellular carcinoma among subject infected with hepatitis C virus: a nested case-control study in Japan
    • Suruky R.J., Mueller N., Hayashi K., et al. Host immune status and incidence of hepatocellular carcinoma among subject infected with hepatitis C virus: a nested case-control study in Japan. Cancer Epidemiol Biomarkers Prev 2006, 15:2521-2525.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 2521-2525
    • Suruky, R.J.1    Mueller, N.2    Hayashi, K.3
  • 9
    • 34248995566 scopus 로고    scopus 로고
    • Hepatitis B virus related hepatocellular carcinoma: epidemiology and pathogenic role of viral factors
    • Liu C.J., Kao J.H. Hepatitis B virus related hepatocellular carcinoma: epidemiology and pathogenic role of viral factors. J Chin Med Assoc 2007, 70:141-145.
    • (2007) J Chin Med Assoc , vol.70 , pp. 141-145
    • Liu, C.J.1    Kao, J.H.2
  • 10
    • 23144446812 scopus 로고    scopus 로고
    • Alcohol and liver cancer
    • McKillop I.H., Schrum L.W. Alcohol and liver cancer. Alcohol 2005, 35:195-203.
    • (2005) Alcohol , vol.35 , pp. 195-203
    • McKillop, I.H.1    Schrum, L.W.2
  • 11
    • 14844318557 scopus 로고    scopus 로고
    • Alcohol in hepatocellular cancer
    • Voigt M.D. Alcohol in hepatocellular cancer. Clin Liver Dis 2005, 9:151-169.
    • (2005) Clin Liver Dis , vol.9 , pp. 151-169
    • Voigt, M.D.1
  • 12
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenetic cirrhosis to hepatocellular carcinoma
    • Bugianesi E., Leone N., Vanni E., et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenetic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002, 123:134-140.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 13
    • 70350284071 scopus 로고    scopus 로고
    • Diabetes mellitus: a " true" independent risk factor for hepatocellular carcinoma?
    • Chun G., Shu-Kun Y. Diabetes mellitus: a " true" independent risk factor for hepatocellular carcinoma?. Hepatobiliary Pancreat Dis Int 2009, 8:465-473.
    • (2009) Hepatobiliary Pancreat Dis Int , vol.8 , pp. 465-473
    • Chun, G.1    Shu-Kun, Y.2
  • 14
    • 70349641345 scopus 로고    scopus 로고
    • Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection
    • Rossi M., Lipworth L., Dal Maso L., et al. Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection. Ann Oncol 2009, 20(10):1736-1740.
    • (2009) Ann Oncol , vol.20 , Issue.10 , pp. 1736-1740
    • Rossi, M.1    Lipworth, L.2    Dal Maso, L.3
  • 15
    • 0035986529 scopus 로고    scopus 로고
    • Dysplastic nodules and hepatocarcinogenesis
    • Theise N.D., Park Y.N., Kojiro M. Dysplastic nodules and hepatocarcinogenesis. Clin Liver Dis 2002, 6:497-512.
    • (2002) Clin Liver Dis , vol.6 , pp. 497-512
    • Theise, N.D.1    Park, Y.N.2    Kojiro, M.3
  • 16
    • 0042093775 scopus 로고    scopus 로고
    • Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development
    • Borzio M., Fargion S., Borzio F., et al. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 2003, 39:208-214.
    • (2003) J Hepatol , vol.39 , pp. 208-214
    • Borzio, M.1    Fargion, S.2    Borzio, F.3
  • 17
    • 0035575999 scopus 로고    scopus 로고
    • Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis
    • Park Y.N., Chae K.J., Kim Y.B., Park C., Theise N. Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis. Cancer 2001, 92:2733-2738.
    • (2001) Cancer , vol.92 , pp. 2733-2738
    • Park, Y.N.1    Chae, K.J.2    Kim, Y.B.3    Park, C.4    Theise, N.5
  • 18
    • 0042669697 scopus 로고    scopus 로고
    • Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type
    • Nakashima Y., Nakashima O., Tanaka M., et al. Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type. Hepatol Res 2003, 26:142-147.
    • (2003) Hepatol Res , vol.26 , pp. 142-147
    • Nakashima, Y.1    Nakashima, O.2    Tanaka, M.3
  • 20
    • 0036920208 scopus 로고    scopus 로고
    • Cellular origin of hepatocellular carcinomas
    • Sell S. Cellular origin of hepatocellular carcinomas. Semin Cell Dev Biol 2002, 13:419-424.
    • (2002) Semin Cell Dev Biol , vol.13 , pp. 419-424
    • Sell, S.1
  • 21
    • 0037397156 scopus 로고    scopus 로고
    • Regulatory mechanisms of viral hepatitis B and C
    • Waris G., Siddiqui A. Regulatory mechanisms of viral hepatitis B and C. J Biosci 2003, 28:311-321.
    • (2003) J Biosci , vol.28 , pp. 311-321
    • Waris, G.1    Siddiqui, A.2
  • 22
    • 0036345943 scopus 로고    scopus 로고
    • Interaction between hepatitis C virus protein and host cell factors
    • Tellinghuisen T.L., Rice C.M. Interaction between hepatitis C virus protein and host cell factors. Curr Opin Microbiol 2002, 5:419-427.
    • (2002) Curr Opin Microbiol , vol.5 , pp. 419-427
    • Tellinghuisen, T.L.1    Rice, C.M.2
  • 23
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • Block T.M., Mehta A.S., Fimmel C.J., et al. Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003, 22:5093-5107.
    • (2003) Oncogene , vol.22 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3
  • 24
    • 0035799529 scopus 로고    scopus 로고
    • Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein
    • Giambartolomei S., Covone F., Levrero M., et al. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene 2001, 20:2606-2610.
    • (2001) Oncogene , vol.20 , pp. 2606-2610
    • Giambartolomei, S.1    Covone, F.2    Levrero, M.3
  • 26
    • 0033655446 scopus 로고    scopus 로고
    • Regulation of glutathione synthesis
    • Lu S.C. Regulation of glutathione synthesis. Cur Top Cell Regul 2000, 36:95-116.
    • (2000) Cur Top Cell Regul , vol.36 , pp. 95-116
    • Lu, S.C.1
  • 27
    • 10844265570 scopus 로고    scopus 로고
    • Recent events in alcoholic liver disease. V. Effects of ethanol on liver regeneration
    • Diehl A.M. Recent events in alcoholic liver disease. V. Effects of ethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol 2005, 288:G1-G6.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Diehl, A.M.1
  • 28
    • 18144411666 scopus 로고    scopus 로고
    • Update treatment approach to hepatocellular carcinoma
    • Llovet J.M. Update treatment approach to hepatocellular carcinoma. J Gastroenterol 2005, 40:225-235.
    • (2005) J Gastroenterol , vol.40 , pp. 225-235
    • Llovet, J.M.1
  • 29
    • 0035146422 scopus 로고    scopus 로고
    • A model to predict survival in patients with and-stage liver disease
    • Kamath P.S., Wiesner R.H., Malinchoc M., et al. A model to predict survival in patients with and-stage liver disease. Hepatology 2001, 33:464-470.
    • (2001) Hepatology , vol.33 , pp. 464-470
    • Kamath, P.S.1    Wiesner, R.H.2    Malinchoc, M.3
  • 30
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival
    • Llovet J.M., Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 2003, 37:429-442.
    • (2003) Hepatology , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 31
    • 0032898237 scopus 로고    scopus 로고
    • Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials
    • Llovet J.M., Bustamante J., Castells A., et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology 1999, 29:62-67.
    • (1999) Hepatology , vol.29 , pp. 62-67
    • Llovet, J.M.1    Bustamante, J.2    Castells, A.3
  • 32
    • 0037087696 scopus 로고    scopus 로고
    • Simplified staging for hepatocellular carcinoma
    • Vauthey J., Lauwers G., Esnaola N., et al. Simplified staging for hepatocellular carcinoma. J Clin Oncol 2002, 20:1527-1536.
    • (2002) J Clin Oncol , vol.20 , pp. 1527-1536
    • Vauthey, J.1    Lauwers, G.2    Esnaola, N.3
  • 34
    • 0021965806 scopus 로고
    • Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients
    • Okuda K., Ohtsui T., Obata H., et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985, 56:918-928.
    • (1985) Cancer , vol.56 , pp. 918-928
    • Okuda, K.1    Ohtsui, T.2    Obata, H.3
  • 35
    • 0037086560 scopus 로고    scopus 로고
    • Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients
    • Leung T.W., Tang A.M., Zee B., et al. Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients. Cancer 2002, 94:1760-1769.
    • (2002) Cancer , vol.94 , pp. 1760-1769
    • Leung, T.W.1    Tang, A.M.2    Zee, B.3
  • 36
    • 0034107047 scopus 로고    scopus 로고
    • Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma
    • CLIP
    • CLIP Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology 2000, 31:840-845.
    • (2000) Hepatology , vol.31 , pp. 840-845
  • 37
    • 0033066135 scopus 로고    scopus 로고
    • A new prognostic classification for predicting survival in patients with hepatocellular carcinoma
    • Chevret S., Trinchet J.C., Mathieu D., et al. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. J Hepatol 1999, 31:133-141.
    • (1999) J Hepatol , vol.31 , pp. 133-141
    • Chevret, S.1    Trinchet, J.C.2    Mathieu, D.3
  • 38
    • 10644225254 scopus 로고    scopus 로고
    • Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score
    • Kudo M., Chung H., Haji S., et al. Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score. Hepatology 2004, 40:1396-1405.
    • (2004) Hepatology , vol.40 , pp. 1396-1405
    • Kudo, M.1    Chung, H.2    Haji, S.3
  • 39
    • 39049174414 scopus 로고    scopus 로고
    • Modified Japan integrated staging is currently the best available staging system for hepatocellular carcinoma patients who have undergone hepatectomy
    • Nanashima A., Sumida Y., Abo T., et al. Modified Japan integrated staging is currently the best available staging system for hepatocellular carcinoma patients who have undergone hepatectomy. J Gastroenterol 2006, 41:250-256.
    • (2006) J Gastroenterol , vol.41 , pp. 250-256
    • Nanashima, A.1    Sumida, Y.2    Abo, T.3
  • 40
    • 0032879468 scopus 로고    scopus 로고
    • Prognosis of hepatocellular carcinoma: the BCLC staging classification
    • Llovet J.M., Bru C., Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999, 19:329-338.
    • (1999) Semin Liver Dis , vol.19 , pp. 329-338
    • Llovet, J.M.1    Bru, C.2    Bruix, J.3
  • 41
    • 33947428441 scopus 로고    scopus 로고
    • The model for end-stage liver disease (MELD)
    • Kamath P.S., Kim W.R. The model for end-stage liver disease (MELD). Hepatology 2007, 45:797-805.
    • (2007) Hepatology , vol.45 , pp. 797-805
    • Kamath, P.S.1    Kim, W.R.2
  • 42
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma. AASLD practice guideline
    • Bruix J., Sherman M. Management of hepatocellular carcinoma. AASLD practice guideline. Hepatology 2005, 42:1208-1236.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 43
    • 79952002527 scopus 로고    scopus 로고
    • Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: review of the randomized clinical trials
    • Llovet J.M., Fuster J., Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: review of the randomized clinical trials. Lancet Oncol 2002, 3:593-603.
    • (2002) Lancet Oncol , vol.3 , pp. 593-603
    • Llovet, J.M.1    Fuster, J.2    Bruix, J.3
  • 44
    • 0038714350 scopus 로고    scopus 로고
    • Small hepatocellular carcinoma in cirrhosis: randomized controlled trial of radiofrequency thermal ablation versus percutaneous ethanol injection
    • Lencioni R., Allagaier H.P., Cioni D., et al. Small hepatocellular carcinoma in cirrhosis: randomized controlled trial of radiofrequency thermal ablation versus percutaneous ethanol injection. Radiology 2003, 228:235-240.
    • (2003) Radiology , vol.228 , pp. 235-240
    • Lencioni, R.1    Allagaier, H.P.2    Cioni, D.3
  • 45
    • 9644265250 scopus 로고    scopus 로고
    • Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma of 4cm or less
    • Lin S., Lin C., Lin C., et al. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma of 4cm or less. Gastroenterology 2004, 127:1714-1723.
    • (2004) Gastroenterology , vol.127 , pp. 1714-1723
    • Lin, S.1    Lin, C.2    Lin, C.3
  • 46
    • 0031854410 scopus 로고    scopus 로고
    • Chemotherapy in hepatocellular carcinoma
    • Okada S. Chemotherapy in hepatocellular carcinoma. Hepatogastroenterology 1998, 45(Suppl. 3):1259-1263.
    • (1998) Hepatogastroenterology , vol.45 , Issue.SUPPL. 3 , pp. 1259-1263
    • Okada, S.1
  • 47
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa G.K., Schwartz L., Ricci S., et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24:4293-4300.
    • (2006) J Clin Oncol , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3
  • 48
    • 34548720158 scopus 로고    scopus 로고
    • SHARP investigators. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a phase III randomized placebo-controlled trial
    • Llovet J., Ricci S., Mazzaferro V., et al. SHARP investigators. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a phase III randomized placebo-controlled trial. J Clin Oncol 2007, LBA1.
    • (2007) J Clin Oncol
    • Llovet, J.1    Ricci, S.2    Mazzaferro, V.3
  • 49
    • 44449085884 scopus 로고    scopus 로고
    • Design and endpoints of clinical trials in hepatocellular carcinoma
    • Llovet J.M., Di Bisceglie A.M., Bruix J., et al. Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst 2008, 100:698-711.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 698-711
    • Llovet, J.M.1    Di Bisceglie, A.M.2    Bruix, J.3
  • 50
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 51
    • 33847118123 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
    • Chang Y.S., Adnane J., Trail P.A., et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol 2007, 59:561-574.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 561-574
    • Chang, Y.S.1    Adnane, J.2    Trail, P.A.3
  • 52
    • 33847069207 scopus 로고    scopus 로고
    • Genomics and signaling pathways in hepatocellular carcinoma
    • Villanueva A., Newell P., Chiang D.Y., et al. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007, 27:55-76.
    • (2007) Semin Liver Dis , vol.27 , pp. 55-76
    • Villanueva, A.1    Newell, P.2    Chiang, D.Y.3
  • 53
    • 33645976174 scopus 로고    scopus 로고
    • Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
    • Calvisi D.F., Ladu S., Gorden A., et al. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 2006, 130:1117-1128.
    • (2006) Gastroenterology , vol.130 , pp. 1117-1128
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 54
    • 7244250405 scopus 로고    scopus 로고
    • Angiogenesis and hepatocellular carcinoma
    • Semela D., Dufour J.F. Angiogenesis and hepatocellular carcinoma. J Hepatol 2004, 41:864-880.
    • (2004) J Hepatol , vol.41 , pp. 864-880
    • Semela, D.1    Dufour, J.F.2
  • 55
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 56
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu L., Cao Y., Chen C., et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006, 66:11851-11858.
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3
  • 57
    • 58049220774 scopus 로고    scopus 로고
    • Randomized phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma
    • Cheng A., Kang Y., Chen Z., et al. Randomized phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma. J Clin Oncol 2008, U26:4509.
    • (2008) J Clin Oncol , vol.U26 , pp. 4509
    • Cheng, A.1    Kang, Y.2    Chen, Z.3
  • 58
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell A.M., Abrams T.J., Yuen H.A., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003, 101:3597-3605.
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 59
    • 37149017305 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with advanced hepatocellular carcinoma
    • Zhu A.X., Sahani D.V., di Tomaso E., et al. A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2007, 25:4637.
    • (2007) J Clin Oncol , vol.25 , pp. 4637
    • Zhu, A.X.1    Sahani, D.V.2    di Tomaso, E.3
  • 60
    • 34548322506 scopus 로고    scopus 로고
    • Assessment of safety and drug induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC)
    • Faivre S.J., Raymond E., Douillard J., et al. Assessment of safety and drug induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). J Clin Oncol 2007, 25:3546.
    • (2007) J Clin Oncol , vol.25 , pp. 3546
    • Faivre, S.J.1    Raymond, E.2    Douillard, J.3
  • 61
    • 34547102484 scopus 로고    scopus 로고
    • Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
    • Zhu A.X., Stuart K., Blaszkowsky L.S., et al. Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer 2007, 110:581-589.
    • (2007) Cancer , vol.110 , pp. 581-589
    • Zhu, A.X.1    Stuart, K.2    Blaszkowsky, L.S.3
  • 62
    • 36348947270 scopus 로고    scopus 로고
    • A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results
    • Gruenwald V., Wilkens L., Gebel M. A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results. J Clin Oncol 2007, 25:A4594.
    • (2007) J Clin Oncol , vol.25
    • Gruenwald, V.1    Wilkens, L.2    Gebel, M.3
  • 63
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • Philip P.A., Mahoney M.R., Allmer C., et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005, 23:6657-6663.
    • (2005) J Clin Oncol , vol.23 , pp. 6657-6663
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 64
    • 34548150925 scopus 로고    scopus 로고
    • Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
    • Thomas M.B., Chadha R., Glover K., et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 2007, 110:1059-1067.
    • (2007) Cancer , vol.110 , pp. 1059-1067
    • Thomas, M.B.1    Chadha, R.2    Glover, K.3
  • 65
    • 33750929534 scopus 로고    scopus 로고
    • Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group's Study E1203
    • O'Dwyer P.J., Giantonio B.J., Levy D.E., et al. Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group's Study E1203. J Clin Oncol 2006, 24:4143.
    • (2006) J Clin Oncol , vol.24 , pp. 4143
    • O'Dwyer, P.J.1    Giantonio, B.J.2    Levy, D.E.3
  • 66
    • 33750915657 scopus 로고    scopus 로고
    • Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial
    • [Abstract 4010]
    • Ramanathan R.K., Belani C.P., Singh D.A., et al. Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. J Clin Oncol (Meeting Abstracts) 2006, 24(18S). [Abstract 4010].
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , Issue.18 S
    • Ramanathan, R.K.1    Belani, C.P.2    Singh, D.A.3
  • 67
    • 0043163428 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
    • Chao Y., Li C.P., Chau G.Y., et al. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann Surg Oncol 2003, 55-62.
    • (2003) Ann Surg Oncol , pp. 55-62
    • Chao, Y.1    Li, C.P.2    Chau, G.Y.3
  • 68
    • 4944234987 scopus 로고    scopus 로고
    • Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
    • Poon R.T., Ho J.W., Tong C.S., et al. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br J Surg 2004, 91:1354-1360.
    • (2004) Br J Surg , vol.91 , pp. 1354-1360
    • Poon, R.T.1    Ho, J.W.2    Tong, C.S.3
  • 69
    • 46449091500 scopus 로고    scopus 로고
    • Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
    • Siegel A.B., Cohen E.I., Ocean A., et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 2008, 26:2992-2998.
    • (2008) J Clin Oncol , vol.26 , pp. 2992-2998
    • Siegel, A.B.1    Cohen, E.I.2    Ocean, A.3
  • 70
    • 36549072713 scopus 로고    scopus 로고
    • The combination of bevacizumab and erlotinib shows significant biological activity in patients with advanced hepatocellular carcinoma
    • Thomas M.B., Chadha R., Iwasaki M., et al. The combination of bevacizumab and erlotinib shows significant biological activity in patients with advanced hepatocellular carcinoma. J Clin Oncol 2007, 25:4567.
    • (2007) J Clin Oncol , vol.25 , pp. 4567
    • Thomas, M.B.1    Chadha, R.2    Iwasaki, M.3
  • 71
    • 33750917456 scopus 로고    scopus 로고
    • Bevacizumab in unresectable hepatocellular carcinoma for patients without metastasis and without invasion of the portal vein
    • Schwartz J., Schwartz M., Lehrer D. Bevacizumab in unresectable hepatocellular carcinoma for patients without metastasis and without invasion of the portal vein. J Clin Oncol 2006, 24:A4144.
    • (2006) J Clin Oncol , vol.24
    • Schwartz, J.1    Schwartz, M.2    Lehrer, D.3
  • 72
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu A.X., Blaszkowsky L.S., Ryan D.P., et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24:1898-1903.
    • (2006) J Clin Oncol , vol.24 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 73
    • 39849106728 scopus 로고    scopus 로고
    • Influence of hepatic dysfunction on safety, tolerability and pharmacokinetics of PTK787/ZK222584 in patients with unresectable HCC
    • Koch I., Baron A., Roberts S. Influence of hepatic dysfunction on safety, tolerability and pharmacokinetics of PTK787/ZK222584 in patients with unresectable HCC. J Clin Oncol 2005, 23:A4134.
    • (2005) J Clin Oncol , vol.23
    • Koch, I.1    Baron, A.2    Roberts, S.3
  • 74
    • 79952005818 scopus 로고    scopus 로고
    • NCCTG phase II trial (N044J) of AZD2171 for patients with hepatocellular carcinoma (HCC)-interim review of toxicity
    • In: Gastrointestinal cancer symposium, Orlando, FL, January 19-21, 2007 [Abstract 186].
    • Alberts SR, Morlan BW, Kim GP, et al. NCCTG phase II trial (N044J) of AZD2171 for patients with hepatocellular carcinoma (HCC)-interim review of toxicity. In: 2007 Gastrointestinal cancer symposium, Orlando, FL, January 19-21, 2007 [Abstract 186].
    • (2007)
    • Alberts, S.R.1    Morlan, B.W.2    Kim, G.P.3
  • 75
    • 11144236505 scopus 로고    scopus 로고
    • MTOR and P70 S6 kinase expression in primary liver neoplasms
    • Sahin F., Kannangai R., Adegbola O., et al. MTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004, 10:8421-8425.
    • (2004) Clin Cancer Res , vol.10 , pp. 8421-8425
    • Sahin, F.1    Kannangai, R.2    Adegbola, O.3
  • 76
    • 33846277588 scopus 로고    scopus 로고
    • In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin
    • Ribatti D., Nico B., Mangieri D., et al. In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin. Histol Histopathol 2007, 22:285-289.
    • (2007) Histol Histopathol , vol.22 , pp. 285-289
    • Ribatti, D.1    Nico, B.2    Mangieri, D.3
  • 77
    • 33947501692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
    • Sieghart W., Fuereder T., Schmid K., et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation 2007, 83:425-432.
    • (2007) Transplantation , vol.83 , pp. 425-432
    • Sieghart, W.1    Fuereder, T.2    Schmid, K.3
  • 78
    • 79952002694 scopus 로고    scopus 로고
    • Available at
    • Available at: http://www.cancer.gov/clinicaltrials/search.
  • 79
    • 1542285169 scopus 로고    scopus 로고
    • Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: relationship to clinicopathological factors and prognosis after hepatic resection
    • Nanashima A., Yano H., Yamaguchi H., et al. Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: relationship to clinicopathological factors and prognosis after hepatic resection. J Gastroenterol 2004, 39(2):148-154.
    • (2004) J Gastroenterol , vol.39 , Issue.2 , pp. 148-154
    • Nanashima, A.1    Yano, H.2    Yamaguchi, H.3
  • 80
    • 0034014185 scopus 로고    scopus 로고
    • Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma
    • Ouchi K., Sugawara T., Ono H., et al. Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma. Dig Surg 2000, 17:42-48.
    • (2000) Dig Surg , vol.17 , pp. 42-48
    • Ouchi, K.1    Sugawara, T.2    Ono, H.3
  • 81
    • 3042585770 scopus 로고    scopus 로고
    • Prognostic significance of Bcl-xLIto in human hepatocellular carcinoma
    • Watanabe J., Kushihata F., Honda K., et al. Prognostic significance of Bcl-xLIto in human hepatocellular carcinoma. Surgery 2004, 135(6):604-612.
    • (2004) Surgery , vol.135 , Issue.6 , pp. 604-612
    • Watanabe, J.1    Kushihata, F.2    Honda, K.3
  • 82
    • 8144225075 scopus 로고    scopus 로고
    • Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome
    • Fields A.C., Cotsonis G., Sexton D., et al. Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome. Mod Pathol 2004, 17:1378-1385.
    • (2004) Mod Pathol , vol.17 , pp. 1378-1385
    • Fields, A.C.1    Cotsonis, G.2    Sexton, D.3
  • 83
    • 0036793871 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma
    • Ikeguci M., Ueta T., Yamane Y., et al. Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. Clin Cancer Res 2002, 8(10):3131-3136.
    • (2002) Clin Cancer Res , vol.8 , Issue.10 , pp. 3131-3136
    • Ikeguci, M.1    Ueta, T.2    Yamane, Y.3
  • 84
    • 0033870417 scopus 로고    scopus 로고
    • Control of apoptosis during angiogenesis by survivin expression in endothelial cells
    • O'Connor D.S., Schechner J.S., Adida C., et al. Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol 2000, 156:393-398.
    • (2000) Am J Pathol , vol.156 , pp. 393-398
    • O'Connor, D.S.1    Schechner, J.S.2    Adida, C.3
  • 85
    • 0035270901 scopus 로고    scopus 로고
    • Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy
    • Kobayashi T., Kubota K., Takayama T., et al. Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy. Am J Surg 2001, 181:284-288.
    • (2001) Am J Surg , vol.181 , pp. 284-288
    • Kobayashi, T.1    Kubota, K.2    Takayama, T.3
  • 86
    • 0035061942 scopus 로고    scopus 로고
    • Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas
    • Ohashi R., Gao C., Miyazaki M., et al. Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas. Anticancer Res 2001, 21:657-662.
    • (2001) Anticancer Res , vol.21 , pp. 657-662
    • Ohashi, R.1    Gao, C.2    Miyazaki, M.3
  • 87
    • 0033766176 scopus 로고    scopus 로고
    • Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma
    • Fiorentino M., Altimari A., D'Errico A., et al. Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma. Clin Cancer Res 2000, 6:3966-3972.
    • (2000) Clin Cancer Res , vol.6 , pp. 3966-3972
    • Fiorentino, M.1    Altimari, A.2    D'Errico, A.3
  • 88
    • 0038666340 scopus 로고    scopus 로고
    • Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas
    • Xu X., Yamamoto H., Sakon M., et al. Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas. Clin Cancer Res 2003, 9(5):1764-1772.
    • (2003) Clin Cancer Res , vol.9 , Issue.5 , pp. 1764-1772
    • Xu, X.1    Yamamoto, H.2    Sakon, M.3
  • 89
    • 0036282936 scopus 로고    scopus 로고
    • P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection
    • Qin L.X., Tang Z.Y., Ma Z.C., et al. P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection. World J Gastroenterol 2002, 8(3):459-463.
    • (2002) World J Gastroenterol , vol.8 , Issue.3 , pp. 459-463
    • Qin, L.X.1    Tang, Z.Y.2    Ma, Z.C.3
  • 90
    • 0034905286 scopus 로고    scopus 로고
    • Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas
    • Matsumura T., Makino R., Mitamura K. Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res 2001, 7:594-599.
    • (2001) Clin Cancer Res , vol.7 , pp. 594-599
    • Matsumura, T.1    Makino, R.2    Mitamura, K.3
  • 91
    • 0036190930 scopus 로고    scopus 로고
    • Expression and prognostic roles of β-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival
    • Inagawa S., Itabashi M., Adachi S., et al. Expression and prognostic roles of β-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival. Clin Cancer Res 2002, 8:450-456.
    • (2002) Clin Cancer Res , vol.8 , pp. 450-456
    • Inagawa, S.1    Itabashi, M.2    Adachi, S.3
  • 92
    • 0033962047 scopus 로고    scopus 로고
    • Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival
    • Endo K., Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol 2000, 32:78-84.
    • (2000) J Hepatol , vol.32 , pp. 78-84
    • Endo, K.1    Terada, T.2
  • 93
    • 0035906821 scopus 로고    scopus 로고
    • Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma
    • Ito Y., Takeda T., Sakon M., et al. Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Br J Cancer 2001, 84:1377-1383.
    • (2001) Br J Cancer , vol.84 , pp. 1377-1383
    • Ito, Y.1    Takeda, T.2    Sakon, M.3
  • 94
    • 0142024103 scopus 로고    scopus 로고
    • Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours
    • Altimari A., Fiorentino M., Gabusi E., et al. Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours. Dig Liver Dis 2003, 35:332-338.
    • (2003) Dig Liver Dis , vol.35 , pp. 332-338
    • Altimari, A.1    Fiorentino, M.2    Gabusi, E.3
  • 95
    • 0036466854 scopus 로고    scopus 로고
    • Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma
    • Giannelli G., Bergamini C., Marinosci F., et al. Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma. Int J Cancer 2002, 97:425-431.
    • (2002) Int J Cancer , vol.97 , pp. 425-431
    • Giannelli, G.1    Bergamini, C.2    Marinosci, F.3
  • 96
    • 0033784038 scopus 로고    scopus 로고
    • Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor
    • Zheng Q., Tang Z.Y., Xue Q., et al. Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor. J Cancer Res Clin Oncol 2000, 126:641-646.
    • (2000) J Cancer Res Clin Oncol , vol.126 , pp. 641-646
    • Zheng, Q.1    Tang, Z.Y.2    Xue, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.