Impaired insight in patients with newly diagnosed nonaffective psychotic disorders with and without deficit features

Schizophrenia Research

Volumn 126, Issue 1-3, 2011, Pages 252-256

  Trotman, Hanan D ^a,b,c   Kirkpatrick, Brian ^a   Compton, Michael T ^d  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Deficit syndrome; First episode psychosis; Insight; Proxy for the deficit syndrome; Schizophrenia

Indexed keywords

ADULT; AFRICAN AMERICAN; ARTICLE; AWARENESS; COGNITION; CONTROLLED STUDY; DELUSION; DEMOGRAPHY; DISEASE SEVERITY; FEMALE; HALLUCINATION; HUMAN; INTROSPECTION; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; PRIORITY JOURNAL; PSYCHOSOCIAL CARE; SCHIZOPHRENIA; SUBSTANCE ABUSE;

ADOLESCENT; ADULT; FEMALE; HUMANS; MALE; PERSONALITY DISORDERS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; SUBSTANCE-RELATED DISORDERS; YOUNG ADULT;

EID: 79952005183     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2010.08.024     Document Type: Article

References (51)

1. Addington D., Addington J., Maticka-Tyndale E. Assessing depression in schizophrenia: the Calgary Depression Scale. Br. J. Psychiatry 1993, 163(Suppl 22):39-44.
2. Amador X.F., Strauss D.H., Yale S.A., Flaum M.M., Endicott J., Gorman J.M. Assessment of insight in psychosis. Am. J. Psychiatry 1993, 150:873-879.
3. Amador X.F., Flaum M., Andreasen N.C., Strauss D.H., Yale S.A., Clark S.C., Gorman J. Awareness of illness in schizophrenia and schizoaffective and mood disorders. Arch. Gen. Psychiatry 1994, 51:826-836.
4. Arango C., Adami H., Sherr J.D., Thaker G.K., Carpenter W.T. Relationship of awareness of dyskinesia in schizophrenia to insight into mental illness. Am. J. Psychiatry 1999, 156:1097-1099.
5. Arango C., Kirkpatrick B., Buchanan R.W. Neurological signs and the heterogeneity of schizophrenia. Am. J. Psychiatry 2000, 157:560-565.
6. Birchwood M., Smith J., Drury V., Healy J., Macmillan F., Slade M. A self-report insight scale for psychosis: reliability, validity and sensitivity to change. Acta Psychiatr. Scand. 1994, 89:62-67.
7. Buchanan R.W., Kirkpatrick B., Heinrichs D.W., Carpenter W.T. Clinical correlates of the deficit syndrome of schizophrenia. Am. J. Psychiatry 1990, 147:290-294.
8. Buchanan R.W., Strauss M.E., Kirkpatrick B., Holstein C., Breier A., Carpenter W.T. Neuropsychological impairments in deficit vs. nondeficit forms of schizophrenia. Arch. Gen. Psychiatry 1994, 51:804-811.
9. Buckley P.F., Stahl S.M. Pharmacological treatment of negative symptoms of schizophrenia: therapeutic opportunity or cul-de-sac?. Acta Psychiatr. Scand. 2007, 115:93-100.
10. Carpenter W.T., Heinrichs D.W., Wagman A.M. Deficit and nondeficit forms of schizophrenia: the concept. Am. J. Psychiatry 1988, 145:578-583.
11. Carroll A., Fattah S., Clyde Z., Coffey I., Owens D.G.C., Johnstone E.C. Correlates of insight and changes in schizophrenia. Schizophr. Res. 1999, 35:247-253.
12. Chen E.Y.H., Kwok C.L., Chen R.Y.L., Kwong P.P.K. Insight changes in acute psychotic episodes: a prospective study of Hong Kong Chinese Patients. J. Nerv. Ment. Dis. 2001, 189:24-30.
13. Cockrell J.R., Folstein M.F. Mini-Mental State Examination (MMSE). Psychopharmacol. Bull. 1988, 24:689-692.
14. Cohen A.S., Docherty N.M. Affective reactivity of speech and emotional experience in patients with schizophrenia. Schizophr. Res. 2004, 69:7-14.
15. Cohen A.S., Saperstein A.M., Gold J.M., Kirkpatrick B., Carpenter W.T., Buchanan R.W. Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date. Schizophr. Bull. 2007, 33:1201-1212.
16. Collins A.A., Remington G.J., Coulter K., Birkett K. Insight, neurocognitive function and symptom clusters in chronic schizophrenia. Schizophr. Res. 1997, 27:37-44.
17. Compton M.T., Chien V.H., Leiner A.S., Goulding S.M., Weiss P.S. Mode of onset of psychosis and family involvement in help-seeking as determinants of duration of untreated psychosis. Soc. Psychiatry Psychiatr. Epidemiol. 2008, 43:975-982.
18. Compton M.T., Goulding S.M., Gordon T.L., Weiss P.S., Kaslow N.J. Family-level predictors and correlates of the duration of untreated psychosis in African American first-episode patients. Schizophr. Res. 2009, 115:338-345.
19. Compton M.T., Ramsay C.E., Shim R.S., Goulding S.M., Gordon T.L., Weiss P.S., Druss B. Health services determinants of the duration of untreated psychosis among African-American first-episode patients. Psychiatr. Serv. 2009, 60:1489-1494.
20. Compton, M.T., Gordon, T.L., Goulding, S.M., Esterberg, M.L., Carter, T., Leiner, A.S., Weiss, P.S., Druss, B., Walker, E.F., Kaslow, N.J., in press. Patient-level predictors and clinical correlates of duration of untreated psychosis in an urban, predominantly African American, first-episode sample. J. Clin. Psychiatry.
21. Compton M.T., Goulding S.M., Walker E.F. Characteristics of the retrospectively assessed prodromal period in hospitalized patients with first-episode nonaffective psychosis: findings from a socially disadvantaged, low-income, predominantly African American population. J. Clin. Psychiatry 2010, 71(10):1279-1285.
22. Donohoe G., Corvin A., Robertson I.H. Are the cognitive deficits associated with impaired insight in schizophrenia specific to executive task performance?. J. Nerv. Ment. Dis. 2005, 193:803-808.
23. Donohoe G., Hayden J., McGlade N., Grada C., Burke T., Barry S., Behan C., Dinan T.G., O'Callaghan E., Gill M., Corvin A.P. Is "clinical" insight the same as "cognitive" insight in schizophrenia?. J. Int. Neuropsychol. Assoc. 2009, 15:471-475.
24. Fenton W.S., McGlashan T.H. Antecedents, symptom progression, and long-term outcome of the deficit syndrome in schizophrenia. Am. J. Psychiatry 1994, 151:351-356.
25. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders 1998, New York State Psychiatric Institute, NY, New York.
26. Folstein M.F., Folstein S.E., McHugh P.R., et al. Mini-Mental State Examination: User's Guide 2001, Psychological Assessment Resources, Inc., Odessa, Florida.
27. Gharabawi G., Bossie C., Turkoz I., Kujawa M., Mahmoud R., Simpson G. The impact of insight on functioning in patients with schizophrenia and schizoaffective disorder receiving risperidone long-acting injectable. J. Nerv. Ment. Dis. 2007, 195:976-982.
28. Karow A., Pajonk F.G. Insight and quality of life in schizophrenia: recent findings and treatment implications. Curr. Opin. Psychiatry 2006, 19:637-641.
29. Kay S.R., Fizbein A., Opler L.A. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr. Bull. 1987, 13:261-276.
30. Kemp R.A., Lambert T.J.R. Insight in schizophrenia and its relationship to psychopathology. Schizophr. Res. 1995, 18:21-28.
31. Kirkpatrick B., Buchanan R.W., McKenney P.D., Alphs L.D., Carpenter W.T. The Schedule for the Deficit Syndrome: an instrument for research in schizophrenia. Psychiatry Res. 1989, 30:119-123.
32. Kirkpatrick B., Buchanan R.W., Breier A., Carpenter W.T. Case identification and stability of the deficit syndrome of schizophrenia. Psychiatry Res. 1993, 47:47-56.
33. Kirkpatrick B., Buchanan R.W., Breier A., Carpenter W.T. Depressive symptoms and the deficit syndrome of schizophrenia. J. Nerv. Ment. Dis. 1994, 182:452-455.
34. Kirkpatrick B., Amador X.F., Flaum M., Yale S.A., Gorman J.M., Carpenter W.T., Tohen M., McGlashan T. The deficit syndrome in the DSM-IV field trial I: alcohol and other drug abuse. Schizophr. Res. 1996, 20:69-77.
35. Kirkpatrick B., Amador X.F., Yale S.A., Bustillo J.R., Buchanan R.W., Tohen M. The deficit syndrome in the DSM-IV field trial. Part II. Depressive episodes and persecutory beliefs. Schizophr. Res. 1996, 20:79-90.
36. Kirkpatrick B., Ram R., Bromet E. The deficit syndrome in the Suffolk County mental health project. Schizophr. Res. 1996, 22:119-126.
37. Kirkpatrick B., Castle D., Murray R.M., Carpenter W.T. Risk factors for the deficit syndrome of schizophrenia. Schizophr. Bull. 2000, 26:233-242.
38. Kirkpatrick B., Buchanan R.W., Ross D.E., Carpenter W.T. A separate disease within the syndrome of schizophrenia. Arch. Gen. Psychiatry 2001, 58:165-171.
39. Lysaker P.H., Bell M.D., Bryson G.J., Kaplan E. Insight and interpersonal function in schizophrenia. J. Nerv. Ment. Dis. 1998, 186:432-436.
40. Mayerhoff D.I., Loebel A.D., Alvir J.M.J., Szymanski S.R., Geisler S.H., Borenstein M., Lieberman J.A. The deficit state in first-episode schizophrenia. Am. J. Psychiatry 1994, 151:1417-1422.
41. Mintz A.R., Dobson K.S., Romney D.M. Insight in schizophrenia: a meta-analysis. Schizophr. Res. 2003, 61:75-88.
42. Mutsatsa S.H., Joyce E.M., Hutton S.B., Barnes T.R.E. Relationship between insight, cognitive function, social function and symptomatology in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 2006, 256:356-363.
43. Parellada M., Fraguas D., Bombin I., Otero S., Castro-Fornieles J., Baeza I., Gonzalez-Pinto A., Graell M., Soutullo C., Paya B., Arango C. Insight correlates in child- and adolescent-onset first-episodes of psychosis: results from the CAFEPS study. Psychol. Med. 2009, 39:1433-1445.
44. Sapara A., Cooke M., Fannon D., Francis A., Buchanan R.W., Anilkumar A.P., Barkataki I., Aasen I., Kuipers E., Kumari V. Prefrontal cortex and insight in schizophrenia: a volumetric MRI study. Schizophr. Res. 2007, 89:22-34.
45. Shad M.U., Tamminga C.A., Cullum M., Haas G.L., Keshavan M.S. Insight and frontal cortical function in schizophrenia: a review. Schizophr. Res. 2006, 86:54-70.
46. Simon V., Hert M.D., Wampers M., Peuskens J., van Winkel R. The relation between neurocognitive dysfunction and impaired insight in patients with schizophrenia. Eur. Psychiatry 2009, 24:239-243.
47. Smith T.E., Hull J.W., Santos L. The relationship between symptoms and insight in schizophrenia: a longitudinal perspective. Schizophr. Res. 1998, 33:63-67.
48. Strauss G.P., Harrow M., Grossman L.S., Rosen C. Periods of recovery in deficit syndrome schizophrenia: a 20-year multi-follow-up longitudinal study. Schizophr. Bull. 2010, 36:788-799.
49. Tiryaki A., Yazici M.K., Anil A.E., Kabakc E., Karaaaolu E., Gou A. Reexamination of the characteristics of the deficit schizophrenia patients. Eur. Arch. Psychiatry Clin. Neurosci. 2003, 253:221-227.
50. Turkington D., Dudley R., Warman D.M., Beck A.T. Cognitive-behavioral therapy for schizophrenia: a review. Focus 2006, 223-233.
51. Young D.A., Campbell Z., Zakzanis K.K., Weinstein E. A comparison between an interview and self-report method of insight assessment in chronic schizophrenia. Schizophr. Res. 2003, 63:103-109.