Restoration of cognitive deficits after statin feeding in TBI

Restorative Neurology and Neuroscience

Volumn 29, Issue 1, 2011, Pages 23-34

  Chauhan, Neelima B ^a,b,c   Gatto, Rodolfo ^a,b,d  

^a JESSE BROWN VA MEDICAL CENTER   (United States)

^b Westside Institute for Science and Education Chicago   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d University of Illinois at Chicago   (United States)

Author keywords

controlled cortical impact injury; learning and memory; lovastatin; morris water maze; pravastatin; simvastatin; spontaneous exploratory working memory; Traumatic brain injury; Y maze

Indexed keywords

MEVINOLIN; PRAVASTATIN; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIET; DRUG MECHANISM; FEMALE; LEARNING; MALE; MOUSE; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; SOMATOSENSORY CORTEX; SPATIAL MEMORY; TRAUMATIC BRAIN INJURY;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN INJURIES; COGNITION DISORDERS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEARNING; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; RANDOM ALLOCATION; RECOVERY OF FUNCTION; SIMVASTATIN;

EID: 79951981195     PISSN: 09226028     EISSN: 18783627     Source Type: Journal    
DOI: 10.3233/RNN-2011-0573     Document Type: Article

References (45)

1. Balduini, W., Mazzoni, E., Carloni, S., De Simoni, M.G., Perego, C., Sironi, L. & Cimino, M. (2003). Prophylactic but not delayed administration of Simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does not affect endothelial nitric oxide synthase expression. Stroke, 34(8), 2007-2012. (Pubitemid 36944798)
2. Cekik, M. & Stein, D.G. (2010). Traumatic brain injury and aging: is a combination of progesterone and vitamin D hormone a simple solution to a complex problem? Neurotherapeutics, 7(1), 81-90.
3. Chauhan, N.B., Siegel, G.J. & Feinstein, D.L. (2004). Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain. Neurochem Res, 29(10), 1897-1911. (Pubitemid 39273654)
4. Chauhan, N.B. & Sandoval, J. (2007). Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice. Phytother Res, 21(7), 629-640. (Pubitemid 47066776)
5. Chauhan, N.B., Gatto, R. & Chauhan, M.B. (2010). Neuroanatomical correlation of behavioral deficits in the CCI model of TBI. J Neurosci Methods, 190(1), 1-9.
6. Chen, S.F., Hung, T.H., Chen, C.C., Lin, K.H., Huang, Y.N., Tsai, H.C. & Wang, J.Y. (2007). Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury. Life Sci, 81(4), 288-298.
7. Chen, G., Zhang, S., Shi, J., Ai, J., Qi, M. & Hang, C. (2009). Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway. Exp Neurol, 216(2), 398-406.
8. Cheng, G., Wei, L., Zhi-Dan, S., Shi-Guang, Z. & Xiang-Zhen, L. (2009). Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway. BMC Neurosci, 10, 7.
9. Cimino, M., Balduini, W., Carloni, S., Gelosa, P., Guerrini, U., Tremoli, E. & Sironi, L. (2005). Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia. Neurotoxicology, 26(5), 929-933. (Pubitemid 41427533)
10. Cimino, M., Gelosa, P., Gianella, A., Nobili, E., Tremoli, E. & Sironi, L. (2007). Statins: multiple mechanisms of action in the ischemic brain. Neuroscientist, 13(3), 208-213. (Pubitemid 46801757)
11. Daimon, M., Aomi, S., Kawamata, T. & Kurosawa, H. (2004). Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces delayed neuronal death following transient forebrain ischemia in the adult rat hippocampus. Neurosci Lett, 362(2), 122-126. (Pubitemid 38759082)
12. Farrell, R., Evans, R. & Corbett, D. (2001). Environmental enrichment enhances recovery of function but exacerbates ischemic cell death. Neuroscience, 107(4), 585-592. (Pubitemid 33097496)
13. Franklin, K. & Paxinos, G. (1998). The Mouse Brain in Stereotaxic Coordinates, (2nd Edition), Academic Press, NY.
14. Fujimoto, S.T., Longhi, L., Saatman, K.E., Conte, V., Stocchetti, N. &McIntosh, T.K. (2004). Motor and cognitive function evaluation following experimental traumatic brain injury. Neurosci Biobehav Rev, 28(4), 365-378.
15. Guyton, J.R. (2006). Benefit versus risk in statin treatment. Am J Cardiol, 97(8A), 95C-97C.
16. Kasturi, B.S. & Stein, D.G. (2009). Progesterone decreases cortical and subcortical edema in young and aged overectomized rats with brain injury. Restor Neurol Neurosci, 27(4), 265-275.
17. Laufs, U., Gertz, K., Dirnagl, U., Böhm, M., Nickenig, G. & Endres, M. (2002). Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res. 942(1-2), 23-30. (Pubitemid 34597065)
18. Li, B., Mahmood, A., Lu, D., Wu, H., Xiong, Y., Qu, C. & Chopp, M. (2009). Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury. Neurosurgery, 65(1), 179-185.
19. Liao, J.K. & Laufs, U. (2005). Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol, 45, 89-118. (Pubitemid 40261799)
20. Lu, D., Qu, C., Goussev, A, Jiang, H., Lu, C., Schallert, T., Mahmood, A., Chen, J., Li, Y. & Chopp, M. (2007). Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma, 24(7), 1132-1146. (Pubitemid 47106287)
21. Mammis, A., McIntosh, T.K. &Maniker, A.H. (2009). Erythropoietin as a neuroprotective agent in traumatic brain injury. Surg Neurol, 71(5), 527-531.
22. Montgomery, K.S., Simmons, R.K., Edwards, G. 3rd, Nicolle, M.M., Gluck, M.A., Myers, C.E. & Bizon, J.L. (2007). Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: Implications for translational research. Neurobiol Aging, Epub ahead of print.
23. Neal, M.D., Cushieri, J., Rosengart, M.R., Alarcon, L.H., Moore, E.E., Maier, R.V., Minei, J.P., Billiar, T.R., Peitzman, A.B. & Sperry, J.L. (2009). Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis. J Trauma, 67(3), 476-482.
24. Orr, J.D. (2008). Statins in the spectrum of neurologic disease. Curr Atheroscler Rep, 10(1), 11-18.
25. Quion, J.A. & Jones, P.H. (2003). Clinical pharmacokinetics of pravastatin. Clin Pharmacokinet, 27(2), 94-103.
26. Richardson, R.M., Singh, A., Sun, D., Fillmore, H.L., Dietrich, D.W. & Bullock, M.R. (2009). Stem cell biology in traumatic brain injury: effects of injury and strategies for repair. J Neurosurg, 112(5), 1125-1138.
27. Sironi, L., Cimino, M., Guerrini, U., Calvio, A.M., Lodetti, B., Asdente, M., Balduini, W., Paoletti, R. & Tremoli, E. (2003).Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol, 23(2), 322-327. (Pubitemid 36231947)
28. Sironi, L., Banfi, C., Brioschi, M., Gelosa, P., Guerrini, U., Nobili, E., Gianella, A., Paoletti, R., Tremoli, E. & Cimino, M. (2006). Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment. Neurobiol Dis, 22(2), 445-451.
29. Stein, D.G. & Sayeed, I. (2010). Is progesterone worth consideration as a treatment for brain injury? Am J Roentgenol, 194(1), 20-22.
30. Stepieñ K., Tomaszewski, M., Czuczwar, S.J. (2005).Neuroprotective properties of statins. Pharmacol Rep, 57(5), 561-569.
31. Tanaka, K., Yagi, T., Shimakoshi, R., Azuma, K., Nanba, T., Ogo, H., Tamura, A.&Asanuma,M. (2009). Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice. Neurosci Lett, 25; 462(3), 235-238.
32. Turkoglu, O.F., Eroglu, H., Okutan, O., Gurcan, O., Bodur, E., Sargon,M. F., Oner, L.& Beskonakl, I.E. (2009). Atorvastatin efficiency after traumatic brain injury in rats. Surg Neurol, 72(2), 146-152.
33. Vaishnavi, S., Rao, V. & Fann, J.R. (2009). Neuropsychiatric problems after traumatic brain injury: unraveling the silent epidemic. Psychosomatics, 50(3), 198-205.
34. van der Most, P.J., Dolga, A.M., Nijholt, I.M., Luiten, P.G. & Eisel, U.L. (2009). Statins: mechanisms of neuroprotection. Prog Neurobiol, 88(1), 64-75.
35. Vink, R., Nimmo & A. J. (2009). Multifunctional drugs for head injury. Neurotherapeutics, 6(1), 28-42.
36. Vree, T.B., Dammers, E., Ulc, I., Horkovics-Kovats, S., Ryska, M. & Merkx, I. (2003). Differences between lovastatin and simvastatin hydrolysis in healthy male and female volunteers:gut hydrolysis of lovastatin is twice that of simvastatin. Scientific-WorldJournal, 3, 1332-1343.
37. Vuletic, S., Riekse, R.G.,Marcovina, S.M., Peskind, E.R., Hazzard, W.R. & Albers, J.J. (2006). Statins of different brain penetrability differentially affect CSF PLTP activity. Dement Geriatr Cogn Disord, 22(5-6), 392-398. (Pubitemid 44726008)
38. Wang, H., Lynch, J.R., Song, P., Yang, H.J., Yates, R.B., Mace, B.,Warner, D.S., Guyton, J.R. & Laskowitz, D.T. (2007).Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol, 206(1), 59-69. (Pubitemid 46935123)
39. Warden, D. (2006). Military TBI during the Iraq and Afghanistan wars. J Head Trauma Rehabil, 21(5), 398-402.
40. Wierzbicki, A.S., Poston, R. & Ferro, A. (2003). The lipid and non-lipid effects of statins. Pharmacol Ther, 99(1), 95-112. (Pubitemid 36694752)
41. Wu, H., Lu, D., Jiang, H., Xiong, Y, Qu, C., Li, B., Mahmood, A., Zhou, D. & Chopp, M. (2008). Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. J Neurosurg, 109(4), 691-698.
42. Wu, H., Lu, D., Jiang, H., Xiong, Y., Qu, C.; Li, B., Mahmood, A., Zhou, D. & Chopp, M. (2008). Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt path way, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma, 25(2), 130-139. (Pubitemid 351252578)
43. Xiong, Y., Mahmood, A. & Chopp, M. (2009). Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs, 14(1), 67-84.
44. Xiong, Y., Mahmood, A., Qu, C., Kazmi, H., Zhang, Z.G., Noguchi, C.T., Schallert, T. & Chopp, M. (2010). Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor. J Neurotrauma, 27(1), 205-215.
45. Yu, S., Kaneko, Y., Bae, E., Stahl, C.E.,Wang, Y., van Loveren, H., Sanberg, P.R. & Borlongan, C.V. (2009). Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits. Brain Res, 1287, 157-163.