Genetically engineered alginate lyase-peg conjugates exhibit enhanced catalytic function and reduced immunoreactivity

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Lamppa, John W ^a   Ackerman, Margaret E ^a   Lai, Jennifer I ^b   Scanlon, Thomas C ^a   Griswold, Karl E ^a,c,d  

^a DARTMOUTH COLLEGE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Dartmouth College

^d DARTMOUTH COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINATE LYASE A1 III; ANTIINFECTIVE AGENT; MACROGOL; MALEIMIDE; THIOL; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; POLY(BETA D MANNURONATE) LYASE; POLY(BETA-D-MANNURONATE) LYASE; POLYSACCHARIDE LYASE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; BIOFILM; CATALYSIS; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG BINDING; DRUG DOSAGE FORM COMPARISON; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SUBSTRATE; GENETIC ENGINEERING; HUMAN; IMMUNOGENICITY; IMMUNOREACTIVITY; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PSEUDOMONAS AERUGINOSA; RABBIT; WILD TYPE; ANIMAL; DRUG EFFECT; ENZYME ACTIVATION; EVALUATION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY; PROTEIN ENGINEERING;

BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS; PSEUDOMONAS AERUGINOSA;

ANIMALS; CATALYSIS; ENZYME ACTIVATION; GENETIC ENGINEERING; HUMANS; IMMUNITY, INNATE; POLYETHYLENE GLYCOLS; POLYSACCHARIDE-LYASES; PROTEIN ENGINEERING; RABBITS; RECOMBINANT PROTEINS;

EID: 79951978803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017042     Document Type: Article

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