Association of heme oxygenase-1 gene polymorphisms with essential hypertension and blood pressure in the Chinese Han population

Genetic Testing and Molecular Biomarkers

Volumn 15, Issue 1-2, 2011, Pages 23-28

  Lin, Rong ^a,b   Fu, Wenqing ^a   Zhou, Weichen ^a   Wang, Ying ^c   Wang, Xiaofeng ^a   Huang, Wei ^c   Jin, Li ^a  

^a FUDAN UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR RISK; CHINESE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; ESSENTIAL HYPERTENSION; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; FEMALE; GENOTYPE; HEME OXYGENASE-1; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 79951963393     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2010.0103     Document Type: Article

References (30)

1. Adeyemo A, Gerry N, Chen G, et al. (2009) A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet 5:e1000564.
2. Angermayr B, Mejias M, Gracia-Sancho J, et al. (2006) Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats. J Hepatol 44:1033-1039.
3. Burton PR, Clayton DG, Cardon LR, et al. (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678. (Pubitemid 46889737)
4. Chakraborty R, Fornage M, Gueguen R, et al. (1991) Population genetics of hypervariable loci: analysis of PCR based VNTR polymorphism within a population. EXS 58:127-143.
5. Chen YH, Lin SJ, Lin MW, et al. (2002) Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 111:1-8.
6. Datla SR, Dusting GJ, Mori TA, et al. (2007) Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress. Hypertension 50:636-642. (Pubitemid 47442726)
7. Durante W, Johnson FK, Johnson RA (2006) Role of carbon monoxide in cardiovascular function. J Cell Mol Med 10:672-686. (Pubitemid 44874276)
8. Excoffier L, Lischer HEL (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Resour (In press).
9. Gaunt TR, Rodriguez S, Zapata C, et al. (2006) MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers. BMC Bioinformatics 7:227.
10. Guo SW, Thompson EA (1992) Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 48:361-372.
11. Hirai H, Kubo H, Yamaya M, et al. (2003) Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 102:1619-1621. (Pubitemid 37022551)
12. Le WD, Xie WJ, Appel SH (1999) Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. J Neurosci Res 56:652-658.
13. Levy D, Ehret GB, Rice K, et al. (2009) Genome-wide association study of blood pressure and hypertension. Nat Genet [Epub ahead of print].
14. Negishi H, Njelekela M, Ikeda K, et al. (2000) Assessment of in vivo oxidative stress in hypertensive rats and hypertensive subjects in Tanzania, Africa. Hypertens Res 23:285-289. (Pubitemid 30326260)
15. Newton-Cheh C, Johnson T, Gateva V, et al. (2009) Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet [Epub ahead of print].
16. Okamoto I, Krogler J, Endler G, et al. (2006) A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with risk for melanoma. Int J Cancer 119:1312-1315. (Pubitemid 44258805)
17. Ono K, Goto Y, Takagi S, et al. (2004) A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese. Atherosclerosis 173:315-319. (Pubitemid 38469802)
18. Ono K, Mannami T, Iwai N (2003) Association of a promoter variant of the haeme oxygenase-1 gene with hypertension in women. J Hypertens 21:1497-1503. (Pubitemid 36994128)
19. Org E, Eyheramendy S, Juhanson P, et al. (2009) Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet 18:2288-2296.
20. Rodrigo R, Passalacqua W, Araya J, et al. (2003) Implications of oxidative stress and homocysteine in the pathophysiology of essential hypertension. J Cardiovasc Pharmacol 42:453-461. (Pubitemid 37210858)
21. Ryter SW, Alam J, Choi AM (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86:583-650.
22. Sabaawy HE, Zhang F, Nguyen X, et al. (2001) Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension 38:210-215. (Pubitemid 34224746)
23. Sabatti C, Service SK, Hartikainen AL, et al. (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41:35-46.
24. Vera T, Kelsen S, Yanes LL, et al. (2007) HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice. Am J Physiol 292:R1472-R1478. (Pubitemid 46557809)
25. Weir BS (1992) Independence of VNTR alleles defined as fixed bins. Genetics 130:873-887.
26. Yamada N, Yamaya M, Okinaga S, et al. (2000) Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 66:187-195. Erratum in: Am J Hum Genet 2001; 2068:1542.
27. Yet SF, Tian R, Layne MD, et al. (2001) Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res 89:168-173. (Pubitemid 34135825)
28. Yun L, Xiaoli L, Qi Z, et al. (2009) Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population. Clin Exp Hypertens 31:534-543.
29. Zhang M, Zhang BH, Chen L, et al. (2002) Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation. Cell Res 12:123-132. (Pubitemid 135708320)
30. Zhang Y, Gao PJ, Zhang XG, et al. (2009) A genome-wide association study of hypertension and blood pressure in Chinese population. Circulation 120:S555.