Bee venom reduces neuroinflammation in the MPTP-induced model of Parkinson's disease

International Journal of Neuroscience

Volumn 121, Issue 4, 2011, Pages 209-217

  Kim, Jong In ^a   Yang, Eun Jin ^b   Lee, Myeong Soo ^b   Kim, Yong Suk ^a   Huh, Youngbuhm ^a   Cho, Ik Hyun ^a   Kang, Sungkeel ^a   Koh, Hyung Kyun ^a  

^a Kyung Hee University   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine (MPTP); Bee venom (BV); dopaminergic neuron; inducible nitric oxide synthase (iNOS); macrophage antigen complex 1 (MAC 1); Parkinson's disease (PD)

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BEE VENOM; CD11B ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; SUBSTANTIA NIGRA PARS COMPACTA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEE VENOMS; CELL DEATH; DISEASE MODELS, ANIMAL; DOPAMINE ANTAGONISTS; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; PARKINSONIAN DISORDERS; RANDOM ALLOCATION; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 79951924281     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2010.548613     Document Type: Article

References (31)

1. Baek, Y. H., Huh, J. E., Lee, J. D., Choi, D. Y., & Park, D. S. (2006). Antinociceptive effect and the mechanism of bee venom acupuncture (apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: Mediation by alpha2-adrenoceptors. Brain Research, 1073-1074, 305-310.
2. Burke, R. E., Cadet, J. L., Kent, J. D., Karanas, A. L., & Jackson-Lewis, V. (1990). An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: Relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats. Journal of Neuroscience Methods, 35(1), 63-73. (Pubitemid 20357867)
3. Cassarino, D. S., Fall, C. P., Swerdlow, R. H., Smith, T. S., Halvorsen, E. M., Miller, S. W., et al. (1997). Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of parkinson's disease. Biochimica et Biophysica Acta, 1362, 77-86. (Pubitemid 28027114)
4. Castro, H. J., Mendez-Lnocencio, J. I., Omidvar, B., Omidvar, J., Santilli, J., Nielsen, H. S., Jr., et al. (2005). A phase I study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis. Allergy Asthma Proceedings, 26, 470-476. (Pubitemid 43105898)
5. Dauer, W., & Przedborski, S. (2003). Parkinson's disease: Mechanisms and models. Neuron, 39, 889-909. (Pubitemid 37130207)
6. Dawson, V. L., Dawson, T. M., Bartley, D. A., Uhl, G. R., & Snyder, S. H. (1993). Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. Journal of Neuroscience, 13, 2651-2661.
7. Dehmer, T., Lindenau, J., Haid, S., Dichgans, J., & Schulz, J. B. (2000). Deficiency of inducible nitric oxide synthase protects against mptp toxicity in vivo. Journal of Neurochemistry, 74, 2213-2216. (Pubitemid 30217680)
8. Doo, A. R., Kim, S. T., Kim, S. N., Moon, W., Yin, C. S., Chae, Y., et al. (2010). Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of parkinson's disease. Neurological Research, 32, 88-91.
9. Franklin, K. B. J., & Paxinos, G. (1997). The Mouse Brain in Stereotaxic Coordinates. San Diego, CA: Academic Press.
10. Gao, H. M., Jiang, J., Wilson, B., Zhang, W., Hong, J. S., & Liu, B. (2002). Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: Relevance to parkinson's disease. Journal of Neurochemistry, 81, 1285-1297. (Pubitemid 34809262)
11. Hirsch, E. C., Breidert, T., Rousselet, E., Hunot, S., Hartmann, A., & Michel, P. P. (2003). The role of glial reaction and inflammation in parkinson's disease. Annals of New York Academy of Science, 991, 214-228. (Pubitemid 36793816)
12. Hunot, S., Boissiere, F., Faucheux, B., Brugg, B., Mouatt-Prigent, A., Agid, Y., et al. (1996). Nitric oxide synthase and neuronal vulnerability in parkinson's disease. Neuroscience, 72, 355-363. (Pubitemid 26111202)
13. Hunot, S., & Hirsch, E. C. (2003). Neuroinflammatory processes in parkinson's disease. Annals of Neurology, 53, S49-S58; discussion S58-S60.
14. Jackson-Lewis, V., & Przedborski, S. (2007). Protocol for the mptp mouse model of parkinson's disease. Nature Protocol, 2, 141-151. (Pubitemid 47044700)
15. Kwon, Y. B., Kim, H. W., Ham, T. W., Yoon, S. Y., Roh, D. H., Han, H. J., et al. (2003). The anti-inflammatory effect of bee venom stimulation in a mouse air pouch model is mediated by adrenal medullary activity. Journal of Neuroendocrinology, 15, 93-96.
16. Kwon, Y. B., Lee, J. D., Lee, H. J., Han, H. J., Mar, W. C., Kang, S. K., et al. (2001). Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain, 90, 271-280.
17. Lee, J. D., Park, H. J., Chae, Y., & Lim, S. (2005). An overview of bee venom acupuncture in the treatment of arthritis. Evidence Based Complementary and Alternative Medicine, 2, 79-84. (Pubitemid 41399517)
18. Lee, M. S., Pittler, M. H., Shin, B. C., Kong, J. C., & Ernst, E. (2008). Bee venom acupuncture formusculoskeletal pain: A review. Journal of Pain, 9, 289-297.
19. Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., et al. (1999). Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the mptp model of parkinson disease. Nature Medicine, 5, 1403-1409.
20. McGeer, P. L., & McGeer, E.G. (2008).Glial reactions in parkinson's disease. Movement Disorders, 23, 474-483.
21. McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003). Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Annals of Neurology, 54, 599-604.
22. Namaka, M., Crook, A., Doupe, A., Kler, K., Vasconcelos, M., Klowak, M., et al. (2008). Examining the evidence: Complementary adjunctive therapies for multiple sclerosis. Neurological Research, 30, 710-719.
23. Park, H. J., Lee, S. H., Son, D. J., Oh, K. W., Kim, K. H., Song, H. S., et al. (2004). Antiarthritic effect of bee venom: Inhibition of inflammation mediator generation by suppression of nf-kappab through interaction with the p50 subunit. Arthritis and Rheumatism, 50, 3504-3515.
24. Park, H. J., Son, D. J., Lee, C. W., Choi, M. S., Lee, U. S., Song, H. S., et al. (2007). Melittin inhibits inflammatory target gene expression and mediator generation via interaction with ikappab kinase. Biochemical Pharmacology, 73, 237-247. (Pubitemid 44883214)
25. Przedborski, S., & Vila, M. (2003). The 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mousemodel: A tool to explore the pathogenesis of parkinson's disease. Annals of New York Academy of Science, 991, 189-198.
26. Shinto, L., Calabrese, C., Morris, C., Sinsheimer, S., & Bourdette, D. (2004). Complementary and alternative medicine in multiple sclerosis: Survey of licensed naturopaths. Journal of Alternative and Complementary Medicine, 10, 891-897. (Pubitemid 39507045)
27. Son, D. J., Lee, J. W., Lee, Y. H., Song, H. S., Lee, C. K., & Hong, J. T. (2007). Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacology & Therapeutics, 115, 246-270. (Pubitemid 47053894)
28. Teismann, P., Vila, M., Choi, D. K., Tieu, K., Wu, D. C., Jackson-Lewis, V., et al. (2003). Cox-2 and neurodegeneration in parkinson's disease. Annals of New York Academy of Science, 991, 272-277. (Pubitemid 36793820)
29. Wesselius, T., Heersema, D. J., Mostert, J. P., Heerings, M., Admiraal-Behloul, F., Talebian, A., et al. (2005). A randomized crossover study of bee sting therapy for multiple sclerosis. Neurology, 65, 1764-1768.
30. Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., et al. (2002). Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mousemodel of parkinson disease. Journal of Neuroscience, 22(5), 1763-1771. (Pubitemid 35386294)
31. Yoon, S. Y., Kim, H. W., Roh, D. H., Kwon, Y. B., Jeong, T. O., Han, H. J., et al. (2005). The anti-inflammatory effect of peripheral bee venom stimulation is mediated by central muscarinic type 2 receptors and activation of sympathetic preganglionic neurons. Brain Research, 1049, 210-216.