The protective effects of ubiquitin C-terminal hydrolase L1 on neurons

Progress in Biochemistry and Biophysics

Volumn 37, Issue 10, 2010, Pages 1054-1058

  Xie, Min ^a   Chen, Qi Cai ^a   Liao, Xiao Mei ^a  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease (AD); Parkinson's disease (PD); Ubiquitin C terminal hydrolase L1 (UCH L1)

Indexed keywords

EID: 79951898899     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2010.00253     Document Type: Article

References (21)

1. Amerik A Y, Hochstrasser M. Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta, 2004, 1695(1-3): 189-207 (Pubitemid 39574973)
2. Osaka H, Wang Y L, Takada K, et al. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet, 2003, 12(16): 1945-1958 (Pubitemid 37038804)
3. Liu Y, Fallon L, Lashuel H A, et al. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell, 2002, 111(2): 209-218 (Pubitemid 35292441)
4. Oddo S. The ubiquitin-proteasome system in Alzheimer's disease. J Cell Mol Med, 2008, 12(2): 363-373 (Pubitemid 351555121)
5. Kabuta T, Setsuie R, Mitsui T, et al. Aberrant molecular properties shared by familial Parkinson's disease- associated mutant UCH-L1 and carbonyl-modified UCH-L1. Hum Mol Genet, 2008, 17 (10): 1482-1496 (Pubitemid 351627344)
6. Walters B J, Campbell S L, Chen P C, et al. Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. Mol Cell Neurosci, 2008, 39(4): 539-548
7. Chung C H, Baek S H. Deubiquitinating enzymes: their diversity and emerging roles. Biochem Biophys Res Commun, 1999, 266(3): 633-640 (Pubitemid 30042487)
8. Nijman S M, Luna-Vargas M P, Velds A, et al. A genomic and functional inventory of deubiquitinating enzymes. Cell, 2005, 123(5): 773-786 (Pubitemid 41721026)
9. Wilkinson K D, Lee K, Deshpande S, et al. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science, 1989, 246(4930): 670-673 (Pubitemid 19283361)
10. Campbell L K, Thomas J R, Lamps L W, et al. Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms. Mod Pathol, 2003, 16(10): 963-969 (Pubitemid 37280811)
11. Das C, Hoang Q Q, Kreinbring C A, et al. Structural basis for conformational plasticity of the Parkinson's disease- associated ubiquitin hydrolase UCH-L1. Proc Natl Acad Sci USA, 2006, 103(12): 4675-4680
12. Setsuie R, Wada K. The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem Int, 2007, 51 (2-4): 105-111 (Pubitemid 47179898)
13. Larsen C N, Krantz B A, Wilkinson K D. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry, 1998, 37(10): 3358-3368 (Pubitemid 28125563)
14. Upadhya S C, Hegde A N. Role of the ubiquitin proteasome system in Alzheimer's disease. BMC Biochem, 2007, 8(Suppl 1): S12: 1-8
15. Choi J, Levey A I, Weintraub S T, et al. Oxidative modifications and down-regulation of ubiquitin carboxyl- terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem, 2004, 279(13): 13256-13264 (Pubitemid 38445905)
16. Tseng B P, Green K N, Chan J L, et al. Aβ inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging, 2008, 29(11): 1607-1618
17. Ren Q G, Liao X M, Chen X Q, et al. Effects of tau phosphorylation on proteasome activity. FEBS Lett, 2007, 581(7): 1521-1528
18. Smith D L, Pozueta J, Gong B, et al. Reversal of long-term dendritic spine alterations in Alzheimer disease models. Proc Natl Acad Sci USA, 2009, 106(39): 16877-16882
19. Gong B, Cao Z, Zheng P, et al. Ubiquitin hydrolase Uch-L1 rescues β-amyloid- induced decreases in synaptic function and contextual memory. Cell, 2006, 126(4): 775-788 (Pubitemid 44233627)
20. Cartier A E, Djakovic S N, Salehi A, et al. Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci, 2009, 29(24): 7857-7868
21. Kyratzi E, Pavlaki M, Stefanis L. The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells. Hum Mol Genet, 2008, 17(14): 2160-2171 (Pubitemid 351911985)