TMEM16A: Advances in calcium-activated chloride channel

Progress in Biochemistry and Biophysics

Volumn 37, Issue 11, 2010, Pages 1175-1181

  Chen, Ya Fei ^a   Li, Ting ^a   An, Hai Long ^a   Yu, Hui ^a   Zhang, Su Hua ^a   Han, Ying Rong ^a   Zhang, Yu Hong ^a   Guo, Peng ^a   Zhan, Yong ^a  

^a HEBEI UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Calcium activated chloride channels (CaCC); Electrophysiology; Molecular basis; Pharmacology; Transmembrane protein 16A (TMEM16A)

Indexed keywords

EID: 79951865355     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2010.00210     Document Type: Article

References (27)

1. Jentsch T J, Stein V, Weinreich F, et al. Molecular structure and physiological function of chloride channels. Physiol Rev, 2002, 82(2): 503-568 (Pubitemid 34654460)
2. Dutzler A, Campbell E B, Cadene M, et al. X-ray structure of a ClC chloride channel at 3.0Å reveals the molecular basis of anion selectivity. Nature, 2002, 415(6869): 287-294 (Pubitemid 34087544)
3. Hartzell C, Putzier I, Arreola J. Calcium-activated chloride channels. Annu Rev Physiol, 2005, 67: 719-758 (Pubitemid 40404508)
4. Barish M E. A transient calcium-dependent chloride current in the immature Xenopus oocyte. J Physiol, 1983, 342(1): 309-325 (Pubitemid 13014154)
5. Eggermont J. Calcium-activated Chloride Channels, (Un)known, (Un)loved?. Proc Am Thorac Soc, 2004, 1(1): 22-27
6. Nilius B, Prenen J, Szücs G, et al. Calcium-activated chloride channels in bovine pulmonary artery endothelial cells. J Physiol (Lond), 1997, 498(2): 381-396 (Pubitemid 27073383)
7. Yang Y D, Cho H, Koo J Y, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature, 2008, 455(7217): 1210-1215
8. Galietta L J V. The TMEM16 protein family: A new class of chloride channels?. Biophys J, 2009, 97(12): 3047-3053
9. 2+ signals. J Gen Physiol, 2000, 115(1): 59-80 (Pubitemid 30043668)
10. Schroeder B C, Cheng T, Jan Y N, et al. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell, 2008, 134(6): 1019-1029
11. Caputo A, Caci E, Ferrera L, et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science, 2008, 322(5901): 590-594
12. Amel G L, Forugh V S, Jason R R, et al. Expression patterns of the Tmem16 gene family during cephalic development in the mouse. Gene Expr Patterns, 2009, 9(3): 178-191
13. West R B, Corless C L, Chen X, et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol, 2004, 165(1): 107-113 (Pubitemid 38821818)
14. Rock J R, Futtner C R, Harfe B D. The transmembrane protein TMEM16A is required for normal development of themurine trachea. Dev Biol, 2008, 321(1): 141-149
15. Huang F, Rock J R, Harfe B D, et al. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Nat Acad Sci USA, 2009, 106(50): 21413-21418
16. - channels. J Physiol, 2009, 587(10): 2127-2139
17. Kuruma A, Hartzell H C. Dynamics of calcium regulation of chloride currents in Xenopus oocytes. Am J Physiol, 1999, 276(1): 161-175
18. Pifferi S, Dibattista M, Menini A. TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflug Arch Eur J Phy, 2009, 458(6): 1023-1038
19. Rock J R, Harfe B D. Expression of TMEM16 paralogs during murine embryogenesis. Dev Dynam, 2008, 237(9):2566-2574
20. 2+-regulated Cl- secretory channel in mouse airways. J Biol Chem, 2009, 284(22): 14875-14880
21. Riordan J R. CFTR function and prospects for therapy. Annu RevBiochem, 2008, 77(1): 701-726
22. Huang X, Gollin S M, Raja S, et al. High-resolution mapping of the 11q13 amplicon and identification of a gene TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Nat Acad Sci USA, 2002, 99(17):11369-11374 (Pubitemid 34920932)
23. West R B, Corless C L, Chen X, et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol, 2004, 165(1):107-113 (Pubitemid 38821818)
24. Carles A, Millon R, Cromer A, et al. Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display. Oncogene, 2006, 25(12): 1821-1831
25. Manoury B, Tamuleviciute A, Tammaro P. TMEM16A/Anoctamin1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells. J Physiol, 2010, doi: 10.1113/jphysiol. 2010.189506
26. - channel in mouse submandibular salivary gland acinar cells. J Biol Chem, 2010, 285(17): 12990-13001
27. 2+-activated Cl- channels. J Clin Invest, 2010, 120(4): 1240-1252