Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events

Journal of Leukocyte Biology

Volumn 89, Issue 2, 2011, Pages 251-257

  Abshire, Michelle Y ^a   Thomas, Keena S ^a   Owen, Katherine A ^a   Bouton, Amy H ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Elongation; Integrin; Invasion; Polarization

Indexed keywords

COLONY STIMULATING FACTOR 1; FOCAL ADHESION KINASE; INTEGRIN RECEPTOR; PAXILLIN; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL INVASION; CELL MOTILITY; CELL STRUCTURE; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; IMMUNOBLOTTING; INFECTION; INFLAMMATION; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE INJURY;

ANIMALS; CELL DIFFERENTIATION; CELL POLARITY; CHEMOTAXIS, LEUKOCYTE; FOCAL ADHESION KINASE 1; INFLAMMATION; INTEGRIN ALPHA4BETA1; INTEGRIN ALPHA5BETA1; MACROPHAGES; MICE; PAXILLIN; SIGNAL TRANSDUCTION;

EID: 79951838520     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0710395     Document Type: Article

References (35)

1. Kummer, C., Ginsberg, M. H. (2006) New approaches to blockade of α4-integrins, proven therapeutic targets in chronic inflammation. Biochem. Pharmacol. 72, 1460-1468. (Pubitemid 44666734)
2. Rugtveit, J., Brandtzaeg, P., Halstensen, T. S., Fausa, O., Scott, H. (1994) Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes. Gut 35, 669-674. (Pubitemid 24163796)
3. Marshall, D., Cameron, J., Lightwood, D., Lawson, A. D. (2007) Blockade of colony stimulating factor-1 (CSF-I) leads to inhibition of DSS-induced colitis. Inflamm. Bowel Dis. 13, 219-224. (Pubitemid 46806231)
4. Mantovani, A., Sica, A. (2010) Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr. Opin. Immunol. 22, 231-237.
5. Webb, S. E., Pollard, J. W., Jones, G. E. (1996) Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1. J. Cell Sci. 109, 793-803. (Pubitemid 26134382)
6. Mantovani, A., Sica, A., Locati, M. (2007) New vistas on macrophage differentiation and activation. Eur. J. Immunol. 37, 14-16. (Pubitemid 46128780)
7. Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A., Locati, M. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25, 677-686. (Pubitemid 39457982)
8. De Fougerolles, A. R., Koteliansky, V. E. (2002) Regulation of monocyte gene expression by the extracellular matrix and its functional implications. Immunol. Rev. 186, 208-220.
9. Huveneers, S., Danen, E. H. (2009) Adhesion signaling - crosstalk between integrins, Src and Rho. J. Cell Sci. 122, 1059-1069.
10. Meng, F., Lowell, C. A. (1998) A β 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 17, 4391-4403. (Pubitemid 28362629)
11. Okigaki, M., Davis, C., Falasca, M., Harroch, S., Felsenfeld, D. P., Sheetz, M. P., Schlessinger, J. (2003) Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc. Natl. Acad. Sci. USA 100, 10740-10745. (Pubitemid 37140098)
12. Owen, K. A., Pixley, F. J., Thomas, K. S., Vicente-Manzanares, M., Ray, B. J., Horwitz, A. F., Parsons, J. T., Beggs, H. E., Stanley, E. R., Bouton, A. H. (2007) Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J. Cell Biol. 179, 1275-1287. (Pubitemid 350277744)
13. Raftopoulou, M., Hall, A. (2004) Cell migration: Rho GTPases lead the way. Dev. Biol. 265, 23-32. (Pubitemid 38018819)
14. Wheeler, A. P., Wells, C. M., Smith, S. D., Vega, F. M., Henderson, R. B., Tybulewicz, V. L., Ridley, A. J. (2006) Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J. Cell Sci. 119, 2749-2757.
15. Bhavsar, P. J., Vigorito, E., Turner, M., Ridley, A. J. (2009) Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation. Exp. Cell Res. 315, 3345-3358.
16. Shima, M., Teitelbaum, S. L., Holers, V. M., Ruzicka, C., Osmack, P., Ross, F. P. (1995) Macrophage-colony-stimulating factor regulates expression of the integrins α 4 β 1 and α 5 β 1 by murine bone marrow macrophages. Proc. Natl. Acad. Sci. USA 92, 5179-5183.
17. Kanner, S. B., Reynolds, A. B., Parsons, J. T. (1989) Immunoaffinity purification of tyrosine-phosphorylated cellular proteins. J. Immunol. Methods 120, 115-124. (Pubitemid 19144203)
18. Hsia, D. A., Lim, S. T., Bernard-Trifilo, J. A., Mitra, S. K., Tanaka, S., den Hertog, J., Streblow, D. N., Ilic, D., Ginsberg, M. H., Schlaepfer, D. D. (2005) Integrin α4β1 promotes focal adhesion kinase-independent cell motility via α4 cytoplasmic domain-specific activation of c-Src. Mol. Cell. Biol. 25, 9700-9712. (Pubitemid 41507866)
19. Weis, S. M., Lim, S. T., Lutu-Fuga, K. M., Barnes, L. A., Chen, X. L., Gothert, J. R., Shen, T. L., Guan, J. L., Schlaepfer, D. D., Cheresh, D. A. (2008) Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J. Cell Biol. 181, 43-50. (Pubitemid 351519763)
20. Wu, L., Bernard-Trifilo, J. A., Lim, Y., Lim, S. T., Mitra, S. K., Uryu, S., Chen, M., Pallen, C. J., Cheung, N. K., Mikolon, D., Mielgo, A., Stupack, D. G., Schlaepfer, D. G. (2008) Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility. Oncogene 27, 1439-1448. (Pubitemid 351317459)
21. Wu, C., Fields, A. J., Kapteijn, B. A., McDonald, J. A. (1995) The role of α 4 β 1 integrin in cell motility and fibronectin matrix assembly. J. Cell Sci. 108, 821-829.
22. Nishiya, N., Kiosses, W. B., Han, J., Ginsberg, M. H. (2005) An α4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat. Cell Biol. 7, 343-352. (Pubitemid 40533123)
23. Goldfinger, L. E., Tzima, E., Stockton, R., Kiosses, W. B., Kinbara, K., Tkachenko, E., Gutierrez, E., Groisman, A., Nguyen, P., Chien, S., Ginsberg, M. H. (2008) Localized α4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ. Res. 103, 177-185.
24. Goldfinger, L. E., Han, J., Kiosses, W. B., Howe, A. K., Ginsberg, M. H. (2003) Spatial restriction of α4 integrin phosphorylation regulates lamellipodial stability and α4β1-dependent cell migration. J. Cell Biol. 162, 731-741. (Pubitemid 37022949)
25. Kim, L. C., Song, L., Haura, E. B. (2009) Src kinases as therapeutic targets for cancer. Nat. Rev. Clin. Oncol. 6, 587-595.
26. Rodina, A., Schramm, K., Musatkina, E., Kreuser, E. D., Tavitian, A., Tatosyan, A. (1999) Phosphorylation of p125FAK and paxillin focal adhesion proteins in src-transformed cells with different metastatic capacity. FEBS Lett. 455, 145-148. (Pubitemid 29322798)
27. Antonov, A. S., Kolodgie, F. D., Munn, D. H., Gerrity, R. G. (2004) Regulation of macrophage foam cell formation by αVβ3 integrin: potential role in human atherosclerosis. Am. J. Pathol. 165, 247-258. (Pubitemid 38821832)
28. Charo, I. F., Nannizzi, L., Smith, J. W., Cheresh, D. A. (1990) The vitronectin receptor α v β 3 binds fibronectin and acts in concert with α 5 β 1 in promoting cellular attachment and spreading on fibronectin. J. Cell Biol. 111, 2795-2800. (Pubitemid 120014560)
29. Tomar, A., Schlaepfer, D. D. (2009) Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr. Opin. Cell Biol. 21, 676-683.
30. Iwanicki, M. P., Vomastek, T., Tilghman, R. W., Martin, K. H., Banerjee, J., Wedegaertner, P. B., Parsons, J. T. (2008) FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J. Cell Sci. 121, 895-905. (Pubitemid 351578125)
31. Ohta, Y., Hartwig, J. H., Stossel, T. P. (2006) FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodeling. Nat. Cell Biol. 8, 803-814. (Pubitemid 44151583)
32. Sanz-Moreno, V., Gadea, G., Ahn, J., Paterson, H., Marra, P., Pinner, S., Sahai, E., Marshall, C. J. (2008) Rac activation and inactivation control plasticity of tumor cell movement. Cell 135, 510-523.
33. Nimnual, A. S., Taylor, L. J., Bar-Sagi, D. (2003) Redox-dependent down-regulation of Rho by Rac. Nat. Cell Biol. 5, 236-241.
34. Hume, D. A. (2006) The mononuclear phagocyte system. Curr. Opin. Immunol. 18, 49-53.
35. Stout, R. D., Watkins, S. K., Suttles, J. (2009) Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages. J. Leukoc. Biol. 86, 1105-1109.