Saccharomyces cerevisiae protein phosphatase Ppz1 and protein kinases Sat4 and Hal5 are involved in the control of subcellular localization of Gln3 by likely regulating its phosphorylation state

Journal of Bioscience and Bioengineering

Volumn 111, Issue 3, 2011, Pages 249-254

  Hirasaki, Masataka ^a   Horiguchi, Masaya ^a   Numamoto, Minori ^a   Sugiyama, Minetaka ^a   Kaneko, Yoshinobu ^a   Nogi, Yasuhisa ^b   Harashima, Satoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Genetic interaction; Hal5; Phosphorylation state; Sat4; Subcellular localization; Yeast

Indexed keywords

DEPHOSPHORYLATIONS; GENETIC INTERACTION; HAL5; NUCLEAR LOCALIZATION; P-TYPE; PHOSPHORYLATED SUBSTRATES; PROTEIN KINASE; PROTEIN PHOSPHATASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE MUTANT; SAT4; SUBCELLULAR LOCALIZATIONS; WILD TYPES;

AMINO ACIDS; ENCODING (SYMBOLS); ENZYMES; PHOSPHATASES; SUBSTRATES; YEAST;

PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATASE; BETA GALACTOSIDASE; CAFFEINE; CELL PROTEIN; GLN3 PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; PROTEIN KINASE HAL5; PROTEIN KINASE SAT4; PROTEIN PHOSPHATASE PPZ1; RAPAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; DEPHOSPHORYLATION; FUNGUS MUTANT; GENE DISRUPTION; IMMUNOFLUORESCENCE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING; WILD TYPE;

CAFFEINE; CELL NUCLEUS; GENE EXPRESSION REGULATION, FUNGAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SODIUM-POTASSIUM-EXCHANGING ATPASE; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 79951812779     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2010.11.013     Document Type: Article

References (24)

1. Zolnierowicz S., Bollen M. Protein phosphorylation and protein phosphatases. EMBO J. 2000, 19:483-488.
2. Aggen J.B., Nairn A.C. Chamberlin, R.: regulation of protein phosphatase-1. Chem. Biol. 2000, 7:R13-R23.
3. Sakumoto N., Mukai Y., Uchida K., Kouchi T., Kuwajima J., Nakagawa Y., Sugioka S., Yamamoto E., Furuyama T., Mizubuchi H. A series of protein phosphatase gene disruptants in Saccharomyces cerevisiae. Yeast 1999, 15:1669-1679. and other 7 authors.
4. Posas F., Casamayor A., Arino J. The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells. FEBS Lett. 1993, 318:282-286.
5. Hampsey M. A review of phenotypes in Saccharomyces cerevisiae. Yeast 1997, 13:1099-1133.
6. Costigan C., Kolodrubetz D., Snyder M. NHP6A and NHP6B, which encode HMG1-like proteins, are candidates for downstream components of the yeast SLT2 mitogen-activated protein kinase pathway. Mol. Cell. Biol. 1994, 14:2391-2403.
7. Sakumoto N., Matsuoka I., Mukai Y., Ogawa N., Kaneko Y., Harashima S. A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast 2002, 19:587-599.
8. Kuranda K., Leberre V., Sokol S., Palamarczyk G., Francois J. Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways. Mol. Microbiol. 2006, 61:1147-1166.
9. Reinke A., Chen J.C., Aronova S., Powers T. Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. J. Biol. Chem. 2006, 281:31616-31626.
10. Posas F., Camps M., Arino J. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells. J. Biol. Chem. 1995, 270:13036-13041.
11. Clotet J., Gari E., Aldea M., Arino J. The yeast ser/thr phosphatases Sit4 and Ppz1 play opposite roles in regulation of the cell cycle. Mol. Cell. Biol. 1999, 19:2408-2415.
12. Yenush L., Merchan S., Holmes J., Serrano R. pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase. Mol. Cell. Biol. 2005, 25:8683-8692.
13. Hirasaki M., Kaneko Y., Harashima S. Protein phosphatase Siw14 controls intracellular localization of Gln3 in cooperation with Npr1 kinase in Saccharomyces cerevisiae. Gene 2008, 409:34-43.
14. Winzeler E.A., Shoemaker D.D., Astromoff A., Liang H., Anderson K., Andre B., Bangham R., Benito R., Boeke J.D., Bussey H. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 1999, 285:901-906. and other 42 authors.
15. Brachmann C.B., Davies A., Cost G.J., Caputo E., Li J., Hieter P., Boeke J.D. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 1998, 14:115-132.
16. Winston F., Dollard C., Ricupero-Hovasse S.L. Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C. Yeast 1995, 11:53-55.
17. Burke D., Dawson D., Stearns T. Methods in Yeast Genetics 2000, A Cold Spring Harbor Laboratory Course Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
18. Mulet J.M., Leube M.P., Kron S.J., Rios G., Fink G.R., Serrano R. A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter. Mol. Cell. Biol. 1999, 19:3328-3337.
19. Crespo J.L., Daicho K., Ushimaru T., Hall M.N. The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in Saccharomyces cerevisiae. J. Biol. Chem. 2001, 27:34441-34444.
20. Beck T., Hall M.N. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 1999, 402:689-692.
21. + and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J. 2002, 21:920-929.
22. Hunter T., Plowman C.D. The protein kinases of budding yeast: six score and more. Trends Biochem. Sci. 1997, 22:18-22.
23. Tate J.J., Cooper T.G. Stress-responsive Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation. J. Biol. Chem. 2007, 282:18467-18480.
24. Shirahige K., Hori Y., Shiraishi K., Yamashita M., Takahashi K., Obuse C., Tsurimoto T., Yoshikawa H. Regulation of DNA-replication origins during cell-cycle progression. Nature 1998, 395:618-621.