The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: Implications for salt tolerance, cell wall integrity and cell cycle progression

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 920-929

  Yenush, Lynne ^a   Mulet, José M ^a   Ariño, Joaquín ^a   Serrano, Ramón ^a  

^a Ciudad Politécnica de la Innovación   (Spain)

Author keywords

Cell cycle; Halotolerance; pH; Phosphatase; Potassium

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE;

AMINO ACID TRANSPORT; ARTICLE; CELL CYCLE; CELL PH; CELL WALL; ENZYME ACTIVITY; NONHUMAN; POTASSIUM METABOLISM; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SALT TOLERANCE;

ADENOSINE TRIPHOSPHATASES; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL WALL; FUNGAL PROTEINS; G1 PHASE; HOMEOSTASIS; ION TRANSPORT; MEMBRANE PROTEINS; OSMOTIC FRAGILITY; PEPTIDES; PHENOTYPE; PHOSPHOPROTEIN PHOSPHATASE; POTASSIUM; POTASSIUM CHLORIDE; PROTON-TRANSLOCATING ATPASES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036500159     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.920     Document Type: Article

References (41)

1. X-ray structure of yeast Ha12p, a major target of lithium and sodium toxicity and identification of framework interactions determining cation sensitivity
2. A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases
3. A series of yeast/Escherichia coli λ expression vectors designed for directional cloning of cDNAs and cre/lox-mediated plasmid excision
4. 2-terminal extension of protein phosphatase PPZ1 has an essential functional role
5. The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle
6. + exchangers
7. The yeast halotolerance determinant Ha13p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase
8. A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Bα
9. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
10. Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants
11. 1
12. Regulation of cation transport in Saccharomyces cerevisiae by the salt tolerance gene HAL3
13. Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae
14. The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast
15. 31P NMR studies of intracellular pH and phosphate metabolism during cell division cycle of Saccharomyces cerevisiae
16. Regulation of yeast H(+)-ATPase by protein kinases belonging to a family dedicated to activation of plasma membrane transporters
17. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation
18. Yeast/E.coli shuttle vectors with multiple unique restriction sites
19. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
20. Alkaline response genes of Saccharomyces cerevisiae and their relationship to the RIM101 pathway
21. A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway
22. Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae
23. Ectopic potassium uptake in trkI trk2 mutants of Saccharomyces cerevisiae correlates with a highly hyperpolarized membrane potential
24. Regulation of monovalent ion homeostasis and pH by the Ser-Thr protein phosphatase SIT4 in Saccharomyces cerevisiae
25. A novel mechanism of ion homeostasis and salt tolerance in yeast: The Ha14 and Ha15 protein kinases modulate the Trk1-Trk2 potassium transporter
26. A salt-sensitive 3′(2′), 5′-bisphosphate nucleotidase involved in sulfate activation
27. +-ATPase. Insights into mechanisms of sodium tolerance
28. Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane
29. Summary of the evidence and discussion concerning the involvement of pHi in the control of cellular function
30. The Skolp repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae
31. Proton pumping and the internal pH of yeast cells, measured with pyranine introduced by electroporation
32. Increased pH and tumorigenicity of fibroblasts expressing a yeast proton pump
33. Dissection of functional domains of the yeast proton-pumping ATPase by directed mutagenesis
34. Growth control strength and active site of yeast plasma membrane ATPase studied by site-directed mutagenesis
35. The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells
36. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells
37. Effect of ATPase inhibitors on the proton pump of respiratory-deficient yeast
38. Ion homeostasis during salt stress in plants
39. A glimpse of the mechanisms of ion homeostasis during salt stress
40. 1 for progression into S phase
41. +-ATPase