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Volumn 72, Issue 1, 2011, Pages 45-52

Discovering molecular targets in cancer with multiscale modeling

Author keywords

Computational modeling; Epidermal growth factor receptor; Multiscale; Non small cell lung cancer; Signaling pathway

Indexed keywords

ANALYTIC METHOD; CANCER MODEL; CANCER RESEARCH; CANCER THERAPY; COMPUTER MODEL; HUMAN; MOLECULAR DYNAMICS; MOLECULARLY TARGETED THERAPY; MULTISCALE MODELING; PHENOTYPE; REVIEW;

EID: 79951795485     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20401     Document Type: Review
Times cited : (13)

References (49)
  • 1
    • 33750093051 scopus 로고    scopus 로고
    • Multiscale modelling of tumour growth and therapy: The influence of vessel normalisation on chemotherapy
    • DOI 10.1080/10273660600968994, PII N82P404106066N11
    • Alarcon T, Owen MR, Byrne HM, Maini PK. 2006. Multiscale modelling of tumour growth and therapy: the influence of vessel normalisation on chemotherapy. Comput Math Methods Med 7:85-119. (Pubitemid 44593983)
    • (2006) Computational and Mathematical Methods in Medicine , vol.7 , Issue.2-3 , pp. 85-119
    • Alarcon, T.1    Owen, M.R.2    Byrne, H.M.3    Maini, P.K.4
  • 2
    • 0242468891 scopus 로고    scopus 로고
    • CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
    • Allen LF, Sebolt-Leopold J, Meyer MB. 2003. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol 30(5 Suppl 16):105-116.
    • (2003) Semin Oncol , vol.30 , Issue.5 SUPPL. 16 , pp. 105-116
    • Allen, L.F.1    Sebolt-Leopold, J.2    Meyer, M.B.3
  • 3
    • 33751217466 scopus 로고    scopus 로고
    • Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
    • Anderson AR, Weaver AM, Cummings PT, Quaranta V. 2006. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127:905-915.
    • (2006) Cell , vol.127 , pp. 905-915
    • Anderson, A.R.1    Weaver, A.M.2    Cummings, P.T.3    Quaranta, V.4
  • 4
    • 35748935235 scopus 로고    scopus 로고
    • Proteins, drug targets and the mechanisms they control: The simple truth about complex networks
    • DOI 10.1038/nrd2381, PII NRD2381
    • Araujo RP, Liotta LA, Petricoin EF. 2007. Proteins, drug targets and the mechanisms they control: the simple truth about complex networks. Nat Rev Drug Discov 6:871-880. (Pubitemid 350042395)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.11 , pp. 871-880
    • Araujo, R.P.1    Liotta, L.A.2    Petricoin, E.F.3
  • 8
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou TC. 2006. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58:621-681.
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.C.1
  • 9
    • 18644364558 scopus 로고    scopus 로고
    • Cancer drugs. Smart weapons prove tough to design
    • Couzin J. 2002. Cancer drugs. Smart weapons prove tough to design. Science 298:522-525.
    • (2002) Science , vol.298 , pp. 522-525
    • Couzin, J.1
  • 10
    • 45849117153 scopus 로고    scopus 로고
    • Advancing cancer systems biology: Introducing the Center for the Development of a Virtual Tumor, CViT
    • Deisboeck TS, Zhang L, Martin S. 2007. Advancing cancer systems biology: introducing the Center for the Development of a Virtual Tumor, CViT. Cancer Inform 5:1-8.
    • (2007) Cancer Inform , vol.5 , pp. 1-8
    • Deisboeck, T.S.1    Zhang, L.2    Martin, S.3
  • 11
    • 0036832606 scopus 로고    scopus 로고
    • Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR
    • Dittmar T, Husemann A, Schewe Y, Nofer JR, Niggemann B, Zanker KS, Brandt BH. 2002. Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. FASEB J 16:1823-1825.
    • (2002) FASEB J , vol.16 , pp. 1823-1825
    • Dittmar, T.1    Husemann, A.2    Schewe, Y.3    Nofer, J.R.4    Niggemann, B.5    Zanker, K.S.6    Brandt, B.H.7
  • 12
    • 34748836375 scopus 로고    scopus 로고
    • Emerging drugs for non-small-cell lung cancer
    • DOI 10.1517/14728214.12.3.449
    • Felip E, Santarpia M, Rosell R. 2007. Emerging drugs for non-small-cell lung cancer. Expert Opin Emerg Drugs 12:449-460. (Pubitemid 47527047)
    • (2007) Expert Opinion on Emerging Drugs , vol.12 , Issue.3 , pp. 449-460
    • Felip, E.1    Santarpia, M.2    Rosell, R.3
  • 13
    • 0036085488 scopus 로고    scopus 로고
    • Identification and review of sensitivity analysis methods
    • DOI 10.1111/0272-4332.00039
    • Frey HC, Patil SR. 2002. Identification and review of sensitivity analysis methods. Risk Anal 22:553-578. (Pubitemid 34655123)
    • (2002) Risk Analysis , vol.22 , Issue.3 , pp. 553-578
    • Frey, H.C.1    Patil, S.R.2
  • 14
    • 67349212164 scopus 로고    scopus 로고
    • Evolution of cell motility in an individual-based model of tumour growth
    • Gerlee P, Anderson AR. 2009. Evolution of cell motility in an individual-based model of tumour growth. J Theor Biol 259:67-83.
    • (2009) J Theor Biol , vol.259 , pp. 67-83
    • Gerlee, P.1    Anderson, A.R.2
  • 15
    • 33745204140 scopus 로고    scopus 로고
    • Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor
    • Green LJ, Marder P, Ray C, Cook CA, Jaken S, Musib LC, Herbst RS, Carducci M, Britten CD, Basche M, et al. 2006. Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor. Clin Cancer Res 12(11 Pt 1):3408-3415.
    • (2006) Clin Cancer Res , vol.12 , Issue.11 PART 1 , pp. 3408-3415
    • Green, L.J.1    Marder, P.2    Ray, C.3    Cook, C.A.4    Jaken, S.5    Musib, L.C.6    Herbst, R.S.7    Carducci, M.8    Britten, C.D.9    Basche, M.10
  • 17
    • 8644234228 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer
    • Han SW, Hwang PG, Chung DH, Kim DW, Im SA, Kim YT, Kim TY, Heo DS, Bang YJ, Kim NK. 2005. Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer. Int J Cancer 113:109-115.
    • (2005) Int J Cancer , vol.113 , pp. 109-115
    • Han, S.W.1    Hwang, P.G.2    Chung, D.H.3    Kim, D.W.4    Im, S.A.5    Kim, Y.T.6    Kim, T.Y.7    Heo, D.S.8    Bang, Y.J.9    Kim, N.K.10
  • 19
    • 24644456999 scopus 로고    scopus 로고
    • Control of MAPK signalling: From complexity to what really matters
    • DOI 10.1038/sj.onc.1208817, PII 1208817
    • Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. 2005. Control of MAPK signalling: from complexity to what really matters. Oncogene 24:5533-5542. (Pubitemid 43119348)
    • (2005) Oncogene , vol.24 , Issue.36 , pp. 5533-5542
    • Hornberg, J.J.1    Binder, B.2    Bruggeman, F.J.3    Schoeberl, B.4    Heinrich, R.5    Westerhoff, H.V.6
  • 20
    • 0037336350 scopus 로고    scopus 로고
    • Integration from proteins to organs: The Physiome Project
    • DOI 10.1038/nrm1054
    • Hunter PJ, Borg TK. 2003. Integration from proteins to organs: the Physiome Project. Nat Rev Mol Cell Biol 4:237-243. (Pubitemid 36288045)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.3 , pp. 237-243
    • Hunter, P.J.1    Borg, T.K.2
  • 22
    • 67449101766 scopus 로고    scopus 로고
    • Equation-free multiscale computation: Algorithms and applications
    • Kevrekidis IG, Samaey G. 2009. Equation-free multiscale computation: algorithms and applications. Annu Rev Phys Chem 60:321-344.
    • (2009) Annu Rev Phys Chem , vol.60 , pp. 321-344
    • Kevrekidis, I.G.1    Samaey, G.2
  • 24
    • 33947507091 scopus 로고    scopus 로고
    • Computational systems biology in drug discovery and development: Methods and applications
    • DOI 10.1016/j.drudis.2007.02.013, PII S1359644607000943
    • Materi W, Wishart DS. 2007. Computational systems biology in drug discovery and development: methods and applications. Drug Discov Today 12:295-303. (Pubitemid 46467486)
    • (2007) Drug Discovery Today , vol.12 , Issue.7-8 , pp. 295-303
    • Materi, W.1    Wishart, D.S.2
  • 25
    • 73949087586 scopus 로고    scopus 로고
    • Personalized cancer therapy with selective kinase inhibitors: An emerging paradigm in medical oncology
    • McDermott U, Settleman J. 2009. Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology. J Clin Oncol 27:5650-5655.
    • (2009) J Clin Oncol , vol.27 , pp. 5650-5655
    • McDermott, U.1    Settleman, J.2
  • 27
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • Morabito A, Piccirillo MC, Falasconi F, De Feo G, Del Giudice A, Bryce J, Di Maio M, De Maio E, Normanno N, Perrone F. 2009. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. Oncologist 14:378-390.
    • (2009) Oncologist , vol.14 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3    De Feo, G.4    Del Giudice, A.5    Bryce, J.6    Di Maio, M.7    De Maio, E.8    Normanno, N.9    Perrone, F.10
  • 30
    • 77957743881 scopus 로고    scopus 로고
    • Systems biology and physiome projects
    • Popel AS, Hunter PJ. 2009. Systems biology and physiome projects. Syst Biol Med 1:153-158.
    • (2009) Syst Biol Med , vol.1 , pp. 153-158
    • Popel, A.S.1    Hunter, P.J.2
  • 31
    • 33748043969 scopus 로고    scopus 로고
    • Influence of the microenvironment on melanoma cell fate determination and phenotype
    • DOI 10.1158/0008-5472.CAN-06-0731
    • Postovit LM, Seftor EA, Seftor RE, Hendrix MJ. 2006. Influence of the microenvironment on melanoma cell fate determination and phenotype. Cancer Res 66:7833-7836. (Pubitemid 44299141)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 7833-7836
    • Postovit, L.-M.1    Seftor, E.A.2    Seftor, R.E.B.3    Hendrix, M.J.C.4
  • 32
    • 0000994551 scopus 로고
    • Sensitivity analysis in chemical kinetics
    • Rabitz H, Kramer M, Dacol D. 1983. Sensitivity analysis in chemical kinetics. Annu Rev Phys Chem 34:419-461.
    • (1983) Annu Rev Phys Chem , vol.34 , pp. 419-461
    • Rabitz, H.1    Kramer, M.2    Dacol, D.3
  • 33
    • 46749151795 scopus 로고    scopus 로고
    • Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: A multiscale approach
    • Ramis-Conde I, Drasdo D, Anderson AR, Chaplain MA. 2008. Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach. Biophys J 95:155-165.
    • (2008) Biophys J , vol.95 , pp. 155-165
    • Ramis-Conde, I.1    Drasdo, D.2    Anderson, A.R.3    Chaplain, M.A.4
  • 34
    • 65349115288 scopus 로고    scopus 로고
    • Multi-scale modelling of cancer cell intravasation: The role of cadherins in metastasis
    • Ramis-Conde I, Chaplain MA, Anderson AR, Drasdo D. 2009. Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis. Phys Biol 6:16008.
    • (2009) Phys Biol , vol.6 , pp. 16008
    • Ramis-Conde, I.1    Chaplain, M.A.2    Anderson, A.R.3    Drasdo, D.4
  • 35
    • 14644394843 scopus 로고    scopus 로고
    • Heterogeneous multiscale method for the modeling of complex fluids and micro-fluidics
    • Ren WQ, E WN. 2005. Heterogeneous multiscale method for the modeling of complex fluids and micro-fluidics. J Comput Phys 204:1-26.
    • (2005) J Comput Phys , vol.204 , pp. 1-26
    • Ren, W.Q.1    E, W.N.2
  • 36
    • 34547771792 scopus 로고    scopus 로고
    • Predictive oncology: A review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth
    • Sanga S, Frieboes HB, Zheng X, Gatenby R, Bearer EL, Cristini V. 2007. Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth. Neuroimage 37(Suppl 1):S120-S134.
    • (2007) Neuroimage , vol.37 , Issue.SUPPL. 1
    • Sanga, S.1    Frieboes, H.B.2    Zheng, X.3    Gatenby, R.4    Bearer, E.L.5    Cristini, V.6
  • 37
    • 33847355217 scopus 로고    scopus 로고
    • Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
    • DOI 10.1038/ncb1543, PII NCB1543
    • Santos SD, Verveer PJ, Bastiaens PI. 2007. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 9:324-330. (Pubitemid 46344612)
    • (2007) Nature Cell Biology , vol.9 , Issue.3 , pp. 324-330
    • Santos, S.D.M.1    Verveer, P.J.2    Bastiaens, P.I.H.3
  • 38
    • 39049190468 scopus 로고    scopus 로고
    • Main approaches to target discovery and validation
    • Sioud M. 2007. Main approaches to target discovery and validation. Methods Mol Biol 360:1-12.
    • (2007) Methods Mol Biol , vol.360 , pp. 1-12
    • Sioud, M.1
  • 40
    • 68149138796 scopus 로고    scopus 로고
    • Biophysical models of tumour growth
    • Tracqui P. 2009. Biophysical models of tumour growth. Rep Prog Phys 72:056701.
    • (2009) Rep Prog Phys , vol.72 , pp. 056701
    • Tracqui, P.1
  • 41
    • 33748308883 scopus 로고    scopus 로고
    • Targeting proteases: Successes, failures and future prospects
    • DOI 10.1038/nrd2092, PII NRD2092
    • Turk B. 2006. Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 5:785-799. (Pubitemid 44323703)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.9 , pp. 785-799
    • Turk, B.1
  • 42
    • 33845410054 scopus 로고    scopus 로고
    • Dynamic modelling and analysis of biochemical networks: Mechanism-based models and model-based experiments
    • DOI 10.1093/bib/bbl040
    • van Riel NA. 2006. Dynamic modelling and analysis of biochemical networks: mechanism-based models and model-based experiments. Brief Bioinform 7:364-374. (Pubitemid 44896739)
    • (2006) Briefings in Bioinformatics , vol.7 , Issue.4 , pp. 364-374
    • Van, R.N.A.W.1
  • 43
    • 67449089661 scopus 로고    scopus 로고
    • The virtual cell - A candidate coordinator for "middle-out" modelling of biological systems
    • Walker DC, Southgate J. 2009. The virtual cell - a candidate coordinator for "middle-out" modelling of biological systems. Brief Bioinform 10:450-461.
    • (2009) Brief Bioinform , vol.10 , pp. 450-461
    • Walker, D.C.1    Southgate, J.2
  • 44
    • 61349156235 scopus 로고    scopus 로고
    • Computational modeling of brain tumors: Discrete, continuum or hybrid?
    • Wang Z, Deisboeck TS. 2008. Computational modeling of brain tumors: discrete, continuum or hybrid? Sci Model Simul 15:381-393.
    • (2008) Sci Model Simul , vol.15 , pp. 381-393
    • Wang, Z.1    Deisboeck, T.S.2
  • 45
    • 40149101292 scopus 로고    scopus 로고
    • Simulating non-small cell lung cancer with a multiscale agent-based model
    • Wang Z, Zhang L, Sagotsky J, Deisboeck TS. 2007. Simulating non-small cell lung cancer with a multiscale agent-based model. Theor Biol Med Model 4:50.
    • (2007) Theor Biol Med Model , vol.4 , pp. 50
    • Wang, Z.1    Zhang, L.2    Sagotsky, J.3    Deisboeck, T.S.4
  • 46
    • 43049167278 scopus 로고    scopus 로고
    • Cross-scale sensitivity analysis of a non-small cell lung cancer model: Linking molecular signaling properties to cellular behavior
    • Wang Z, Birch CM, Deisboeck TS. 2008. Cross-scale sensitivity analysis of a non-small cell lung cancer model: linking molecular signaling properties to cellular behavior. Biosystems 92:249-258.
    • (2008) Biosystems , vol.92 , pp. 249-258
    • Wang, Z.1    Birch, C.M.2    Deisboeck, T.S.3
  • 47
    • 69849103228 scopus 로고    scopus 로고
    • Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model
    • Wang Z, Birch CM, Sagotsky J, Deisboeck TS. 2009. Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model. Bioinformatics 25:2389-2396.
    • (2009) Bioinformatics , vol.25 , pp. 2389-2396
    • Wang, Z.1    Birch, C.M.2    Sagotsky, J.3    Deisboeck, T.S.4
  • 48
    • 79951799620 scopus 로고    scopus 로고
    • Identifying therapeutic targets in a combined EGFR-TGFβR signaling cascade using a multiscale agent-based cancer model
    • in press
    • Wang Z, Bordas V, Sagotsky J, Deisboeck TS. 2010. Identifying therapeutic targets in a combined EGFR-TGFβR signaling cascade using a multiscale agent-based cancer model. Math Med Biol (in press).
    • (2010) Math Med Biol
    • Wang, Z.1    Bordas, V.2    Sagotsky, J.3    Deisboeck, T.S.4


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