Bioavailability of fermented Korean red ginseng

Journal of Food Science and Nutrition

Volumn 14, Issue 3, 2009, Pages 201-207

  Lee, Hyun Jung ^a   Jung, Eun Young ^a   Lee, Hyun Sun ^a   Kim, Bong Gwan ^b   Kim, Jeong Hoon ^b   Yoon, Taek Joon ^c   Oh, Sung Hoon ^d   Suh, Hyung Joo ^a  

^a Korea University   (South Korea)

^b Woongjin Foods Co Ltd   (South Korea)

^c Yuhan College   (South Korea)

^d Ansan University   (South Korea)

Author keywords

Bioavailability; Everted intestinal sac; Fermented red ginseng; Franz cell; Ginsenoside metabolites

Indexed keywords

PANAX GINSENG; RATTUS;

EID: 79951777867     PISSN: 1226332X     EISSN: None     Source Type: Journal    
DOI: 10.3746/jfn.2009.14.3.201     Document Type: Article

References (33)

1. Park JH. 2004. Sun ginseng-a new processed ginseng with fortified activity. Food Ind Nutr 9: 23-27.
2. Kitagawa I, Yoshikawa M, Yoshihara M, Hayashi T, Taniyama T. 1983. Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra. Yakugaku Zasshi 103: 612-622.
3. Wu JY, Gardner BH, Murphy CI, Seals JR, Kensil CR, Recchia J, Beltz GA, Newman GW, Newman MJ. 1992. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J Immunol 148: 1519-1525.
4. Mochizuki M, Yoo CY, Matsuzawa K, Sato K, Saiki I, Tono-oka S, Samukawa K, Azuma I. 1995. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)-and 20(S)-ginsenoside Rg3, of red ginseng. Biol Pharm Bull 18: 1197-1202.
5. Sato K, Mochizuki M, Saiki I, Yoo YC, Samukawa K, Azuma I. 1994. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng-ginsenoside Rb2. Biol Pharm Bull 17: 635-639.
6. Bae EA, Park SY, Kim DH. 2000. Constitutive β-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull 23: 1481-1485.
7. Bae EA, Han MJ, Choo MK, Park SY, Kim DH. 2002. Metabolism of 20(S)-and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 25: 58-63.
8. Kanaoka M, Akao T, Kobashi K. 1994. Metabolism of ginseng saponins, ginsenosides, by human intestinal bacteria. J Tradit Med 11: 241-245.
9. Wakabayashi C, Hasegawa H, Murata J, Saiki I. 1997. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 9: 411-417.
10. Wakabayashi C, Hasegawa H, Murata J, Saiki I. 1997. The expression of in vivo anti-metastatic effect of ginseng protopanaxatriol saponins is mediated by their intestinal bacterial metabolites after oral administration. J Trad Med 14: 180-185.
11. Hasegawa H, Lee KS, Nagaoka T, Tezuka Y, Uchiyama M, Kadota S, Saiki I. 2000. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters. Biol Pharm Bull 23: 298-304.
12. Hasegawa H, Saiki I. 2000. Oleoyl triterpene glycoside biosynthesized from ginseng suppresses growth and metastasis of murine melanoma B16-F10 tumor via immunostimulation. J Trad Med 17: 186-193.
13. Hasegawa H, Suzuki R, Nagaoka T, Tezuka Y, Kadota S, Saiki I. 2000. Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acidconjugate of protopanaxatriol. Biol Pharm Bull 25: 861-866.
14. Hur HJ, Lee KW, Kim HY, Chung DK, Lee HJ. 2006. In vitro immunopotentiating activities of cellular fractions of lactic acid bacteria isolated from kimchi and bifidobacteria. J Microbiol Biotechnol 16: 661-666.
15. Wakabayashi C, Murakami K, Hasegawa H, Murata J, Saiki I. 1998. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun 246: 725-730.
16. Lou DW, Saito Y, Jinno K. 2005. Solid-phase extraction and high-performance liquid chromatography for simultaneous determination of important bioactive ginsenosides in pharmaceutical preparations. Chromatographia 62: 349-354.
17. Kim SJ, Murthy HN, Hahna EJ, Lee HL, Paek KY. 2007. Parameters affecting the extraction of ginsenosides from the adventitious roots of ginseng (Panax ginseng C.A. Meyer). Sep Purif Technol 56: 401-406.
18. Sonavane G, Tomoda K, Sano A, Ohshima H, Terada H, Makino K. 2008. In vitro permeation of gold nanoparticles through rat skin and rat intestine: effect of particle size. Colloids Surf B Biointerfaces 65: 1-10.
19. Tandon S, Das M, Khanna SK. 1993. Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: role of Na+, K(+)-ATPase. Nat Toxins 1: 235-240.
20. Taga MS, Miller EE, Pratt DE. 1984. Chia seeds as a source of natural lipid antioxidants. J Am Oil Chem Soc 61: 928-931.
21. Dou D, Jin L, Chen Y. 1999. Advances and prospects of the study on chemical constituents and pharmacological activities of Panax ginseng. J Shen yang Pharm Univ 16: 151-156.
22. Luo ZY, Lu QH, Liu SP, Chen XH, Luo JQ, Tan LJ, Hu WX. 2003. Screening and identification of novel gens involved in biosynthesis of ginsenoside in Panax ginseng plant. ACTA Biochem Biophys Sin 35: 554-560.
23. Miller NJ, Ruiz-Larrea MB. 2002. Flavonoids and other plant phenols in the diet: what is their significance as antioxidants? J Nutr Environ Med 12: 39-51.
24. Hutabarat LS, Greenfield H, Mulholland M. 2000. Quantitative determination of isoflavones and coumestrol in soybean by column liquid chromatography. J Chromatogr A 886: 55-63.
25. Pandjaitan N, Hettiarachchy N, Ju ZY. 2000. Enrichment of genistein in soy protein concentrate with β-glucosidase. Food Chem Toxicol 65: 403-407.
26. Karikura M, Miyase T, Tanizawa H, Takino Y, Taniyama T, Hayashi T. 1990. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats. Chem Pharm Bull 38: 2859-2861.
27. Yoshikoshi M, Kahara T, Yoshiki Y, Ito M, Furukawa Y, Okubo K, Amarowicz R. 1995. Metabolism and nonabsorption of soybean hypocotyl saponins in the rat model. Acta Alimentaria 24: 355-364.
28. Flaoyen A, Wilkins AL, Deng D, Brekke T. 2001. Ovine metabolism of saponins: Evaluation of a method for estimating the ovine uptake of steroidal saponins from Narthecium ossifragum. Vet Res Commun 25: 225-238.
29. Lee SJ, Ko WG, Kim JH, Sung JH, Lee SJ, Moon CK, Lee BH. 2000. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem Pharmacol 60: 677-685.
30. Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK, Kim CK, Park JH. 2000. Steaming of ginseng at high temperature enhances biological activity. J Nat Prod 63: 1702-1704.
31. Tawab MA, Bahr U, Karas M, Wurglics M, Schubert-Zsilavecz M. 2003. Degeneration of ginsenosides in humans after oral administration. Drug Metab Dispos 31: 1065-1071.
32. Kanaoka M, Kato H, Shimada F, Yano S. 1992. Studies on the enzyme immuno-assay of bioactive constituents in oriental medicinal drugs VI: Enzyme immuno-assay of ginsenoside Rb-1 from Panax ginseng. Chem Pharm Bull 40: 314-317.
33. Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. 1998. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 50: 1155-1160.